Protein Alignment Traf6 and Traf3

DIOPT Version :9

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_035762.2
• Gene: Traf3 / 22031
• MGIID: 108041
• Length: 567
• Species: Mus musculus
• Alignment Length: 577
• Identity: 111/577 - (19%)
• Similarity: 198/577 - (34%)
• Gaps: 193/577 - (33%)

  Fly    65 ASGA--PTPPKSLALNQNHHYAPGSDTSGEQEE--ELLDSRYECAICIDWLNEPVLTSCGHRFCR 125
            |:|.  |.||..|..::........:..|.:|:  :.::.:|:|..|...|..|..|.||||||.
Mouse     9 AAGTLQPNPPLKLQPDRGAGSVLVPEQGGYKEKFVKTVEDKYKCEKCRLVLCNPKQTECGHRFCE 73

  Fly   126 SCLTAWMQKNNQCCPMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHL- 189
            ||:.|.:..::..|....:.: .:..:|.||..:|||..|:..|.|...||:...:...|..||
Mouse    74 SCMAALLSSSSPKCTACQESI-IKDKVFKDNCCKREILALQVYCRNEGRGCAEQLTLGHLLVHLK 137

  Fly   190 -----------------------------PSCPYR--------------RQQEPQEEKCPFAKIK 211
                                         .:|.||              :.|:.::..||...:.
Mouse   138 NECQFEELPCLRADCKEKVLRKDLRDHVEKACKYREATCSHCKSQVPMIKLQKHEDTDCPCVVVS 202

  Fly   212 CDFVGRPETNQLEEHLKADMPHHMQLMLQA------------FQQTAIATWQPHKPSTSGAAVEN 264
            |     |....::..|::::..|:...:.|            ||    .|.|..|...:.:||
Mouse   203 C-----PHKCSVQTLLRSELSAHLSECVNAPSTCSFKRYGCVFQ----GTNQQIKAHEASSAV-- 256

  Fly   265 GHGQQQLPPPPQYANGVDEQI-------------VQTMYQRIVVLE---QRTRE----------- 302
                |.:....:::|.:::::             :|:::.:|...|   :|.:|
Mouse   257 ----QHVNLLKEWSNSLEKKVSLLQNESVEKNKSIQSLHNQICSFEIEIERQKEMLRNNESKILH 317

  Fly   303 -------QETRLENMQKQLRLARQQ---------------------------------------- 320
                   |..:|:.:.|::|..||.
Mouse   318 LQRVIDSQAEKLKELDKEIRPFRQNWEEADSMKSSVESLQNRVTELESVDKSAGQAARNTGLLES 382

  Fly   321 ----------------APVDPRYS-------NGTIVWRIEQLGALVARLRANANNQVYSHECYTS 362
                            |.:|.|:.       ||.::|:|.................:||...||.
Mouse   383 QLSRHDQMLSVHDIRLADMDLRFQVLETASYNGVLIWKIRDYKRRKQEAVMGKTLSLYSQPFYTG 447

  Fly   363 PHGYKFCARLNI----QPRKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTI 423
            ..|||.|||:.:    ..:..| |||...:|:.|.|..|.||||.::.|.::....:.....|..
Mouse   448 YFGYKMCARVYLNGDGMGKGTH-LSLFFVIMRGEYDALLPWPFKQKVTLMLMDQGSSRRHLGDAF 511

  Fly   424 MTKPEILAFHKPREAISTRGFGFLEYAN------ISNIIQLG-FCADDRLLIKIEIN 473
            ...|...:|.||.        |.:..|:      ...:::.| :..||.:.||:.::
Mouse   512 KPDPNSSSFKKPT--------GEMNIASGCPVFVAQTVLENGTYIKDDTIFIKVIVD 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	15/37 (41%)
		Sina	163..>230	CDD:302762	17/110 (15%)
		MATH_TRAF6	330..473	CDD:239745	38/153 (25%)
Traf3	NP_035762.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..26		6/16 (38%)
		RING-HC_TRAF3	50..91	CDD:319554	16/40 (40%)
		zf-TRAF	135..191	CDD:280357	6/55 (11%)
		zf-TRAF	196..246	CDD:424248	10/58 (17%)
		Smc	<251..>432	CDD:224117	22/186 (12%)
		MATH_TRAF3	377..562	CDD:239746	42/193 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D391991at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820