Protein Alignment Traf6 and Traf2

DIOPT Version :10

• Sequence 1: NP_511080.2
• Gene: Traf6 / 31746
• FlyBaseID: FBgn0265464
• Length: 475
• Species: Drosophila melanogaster
• Sequence 2: NP_001277342.1
• Gene: Traf2 / 22030
• MGIID: 101835
• Length: 508
• Species: Mus musculus
• Alignment Length: 559
• Identity: 116/559 - (20%)
• Similarity: 190/559 - (33%)
• Gaps: 204/559 - (36%)

  Fly    65 ASGAPTPPKSLALNQNHHYAPGSDTS--GEQEEELLDSRYECAICIDWLNEPVLTSCGHRFCRSC 127
            |:.:.|.|.||.|.|     ||...:  |.:    |:::|.|:.|.:.|..|....||||:|..|
Mouse     2 AAASVTSPGSLELLQ-----PGFSKTLLGTR----LEAKYLCSACKNILRRPFQAQCGHRYCSFC 57

  Fly   128 LTAWMQ----------KNNQCCPMDNK-----RLSAEHDIFPDNYTRREIEQL------------ 165
            ||:.::          :|...|..:..     .:......||||..|||:|.|
Mouse    58 LTSILRCASILSSSGPQNCAACVYEGLYEEGISILESSSAFPDNAARREVESLPAVCPNDGCTWK 122

  Fly   166 -------------------------------------KRDCPNSSLGCSVVASP---IELHRHLP 190
                                                 :::||..||.|....:|   ::|..|..
Mouse   123 GTLKEYESCHEGLCPFLLTECPACKGLVRLSEKEHHTEQECPKRSLSCQHCRAPCSHVDLEVHYE 187

  Fly   191 SCP--------YRRQQEPQE------EKCPFAKIKCDF--VG---RPETNQLEEHLKADMPHHMQ 236
            .||        ..:::.|:|      ..|...::.|.|  ||   ..||..|::|....:..|:.
Mouse   188 VCPKFPLTCDGCGKKKIPRETFQDHVRACSKCRVLCRFHTVGCSEMVETENLQDHELQRLREHLA 252

  Fly   237 LMLQAFQQTAIATWQPHKPSTSGAAVENGHGQQQLPPPPQYANGVDEQIVQTMYQRIVVLEQR-- 299
            |:|.:|.:.                              |.:.|...|:...:.||..:|||:
Mouse   253 LLLSSFLEA------------------------------QASPGTLNQVGPELLQRCQILEQKIA 287

  Fly   300 ---------TREQE--------------------TRLENMQKQLR------------LARQQAPV 323
                     .||.|                    ..|.|..:||.            |.::.:.:
Mouse   288 TFENIVCVLNREVERVAVTAEACSRQHRLDQDKIEALSNKVQQLERSIGLKDLAMADLEQKVSEL 352

  Fly   324 DPRYSNGTIVWRIEQLGALVARLRANANNQVYSHECYTSPHGYKFCARLNIQ----PRKPHVLSL 384
            :....:|..:|:|...........|.....::|...|||.:|||.|.|:.:.    .|..| |||
Mouse   353 EVSTYDGVFIWKISDFTRKRQEAVAGRTPAIFSPAFYTSRYGYKMCLRVYLNGDGTGRGTH-LSL 416

  Fly   385 HVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEIL--AFHKPREAISTRGFGFL 447
            ...:|:..||..|.|||..::.|.::   |....:|.....:|::.  :|.:|           :
Mouse   417 FFVVMKGPNDALLQWPFNQKVTLMLL---DHNNREHVIDAFRPDVTSSSFQRP-----------V 467

  Fly   448 EYANISNIIQLGFC------------ADDRLLIKIEINI 474
            ...||::...| ||            .||.:.||..:::
Mouse   468 SDMNIASGCPL-FCPVSKMEAKNSYVRDDAIFIKAIVDL 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	mRING-HC-C3HC3D_LNX1-like	101..143	CDD:438299	15/51 (29%)
		Sina	169..>230	CDD:460824	21/82 (26%)
		MATH_TRAF6	330..473	CDD:239745	40/160 (25%)
Traf2	NP_001277342.1	RING_Ubox	31..80	CDD:473075	14/48 (29%)
		zf-TRAF	185..242	CDD:280357	13/56 (23%)
		TRAF_BIRC3_bd	274..337	CDD:465226	12/62 (19%)
		Important for interaction with BIRC2 and BIRC3	290..300		1/9 (11%)
		MATH_TRAF2	341..504	CDD:239747	41/178 (23%)