DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf6 and Lnx1

DIOPT Version :9

Sequence 1:	NP_511080.2	Gene:	Traf6 / 31746	FlyBaseID:	FBgn0265464	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001153049.1	Gene:	Lnx1 / 16924	MGIID:	1278335	Length:	728	Species:	Mus musculus

Alignment Length:	441	Identity:	86/441 - (19%)
Similarity:	144/441 - (32%)	Gaps:	156/441 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 PTP-PKSLALNQNHHYAPGSDTSGEQEE-----ELLDSRYECAICIDWLNEPVLTSCGHRFCRSC 127
            |:| |..:...|||        |.|:..     |.:|....|.||:..|.:|:.|.|||.:|..|
Mouse    12 PSPEPLCIVCGQNH--------SPEENHFYTYTEDVDDDLICHICLQALLDPLDTPCGHTYCTLC 68

  Fly   128 LTAWMQKNNQCCPMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSC 192
            ||.::.:.: .||:|.|.:..:|                  |..||:..:.:     |::.|.:|
Mouse    69 LTNFLVEKD-FCPVDRKPVVLQH------------------CKKSSILVNKL-----LNKLLVTC 109

  Fly   193 PYRRQQEPQEEKCPFAKIKCDFVGRPETNQLEEHLKADMPHHMQLMLQAFQQTAIATWQPHK--- 254
            |:       .|.|.....:|                 |:.||.|...:......:...:..:
Mouse   110 PF-------TEHCTEVLQRC-----------------DLQHHFQTSCKGASHYGLTKDRKRRSQD 150

  Fly   255 ---------------PSTSGAAVENGHGQQQLPPPPQYANGVDEQIVQTMYQRIVVLEQRTREQE 304
                           |..|.||..:....:.....|.|.:.|::.      :.:.......|...
Mouse   151 GCPDGCASLMATTLSPEVSAAATISLMTDEPGLDNPAYVSSVEDG------EPVANSSDSGRSNR 209

  Fly   305 TRLENMQKQLRLARQQAPVDPRYSNGTIVWRIEQLGALVA----RLRANANNQVYSHECYTSPHG 365
            ||....::....:|....::...|    ..|..:.|::||    :.|.|:.|.       |.|
Mouse   210 TRARPFERSTMRSRSFKKINRALS----ALRRTKSGSVVANHVDQGRDNSENT-------TVP-- 261

  Fly   366 YKFCARLNIQPRKPHVLSLHVHLMQSENDYHLDWPFKGRIKLCMVHPADATLSQHDTIMTKPEIL 430
                   .:.||..|::.                  .|.|....::.||
Mouse   262 -------EVFPRLFHLIP------------------DGEITSIKINRAD---------------- 285

  Fly   431 AFHKPREAISTRGFGFLE----YANISNIIQLGFCA-DDRLL---IKIEIN 473
                |.|::|.|..|..|    :..|.:|.:.|..| |.|||   |.:::|
Mouse   286 ----PSESLSIRLVGGSETPLVHIIIQHIYRDGVIARDGRLLPGDIILKVN 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	14/37 (38%)
		Sina	163..>230	CDD:302762	10/66 (15%)
		MATH_TRAF6	330..473	CDD:239745	31/154 (20%)
Lnx1	NP_001153049.1	mRING-HC-C3HC3D_LNX1	42..83	CDD:319693	15/41 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	185..220		6/40 (15%)
		NPXY motif	185..188		1/2 (50%)
		Interaction with MAGEB18. /evidence=ECO:0000250	186..244		10/67 (15%)
		PDZ_signaling	276..360	CDD:238492	19/77 (25%)
		PDZ_signaling	384..464	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	481..500
		PDZ_signaling	506..589	CDD:238492
		PDZ_signaling	637..721	CDD:238492
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810