DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf6 and RNF151

DIOPT Version :9

Sequence 1:	NP_511080.2	Gene:	Traf6 / 31746	FlyBaseID:	FBgn0265464	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	XP_005255186.1	Gene:	RNF151 / 146310	HGNCID:	23235	Length:	254	Species:	Homo sapiens

Alignment Length:	257	Identity:	65/257 - (25%)
Similarity:	100/257 - (38%)	Gaps:	50/257 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 PGSDT----SGEQEEELL----DSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWM--QKNNQCC 139
            ||:||    .|..:..|.    ||.:.|::|...|..|....|.|.||:.|:..|:  ||...||
Human     2 PGADTWPLQGGGYDLNLFASPPDSNFVCSVCHGVLKRPARLPCSHIFCKKCILRWLARQKTCPCC 66

  Fly   140 PMDNKRLSAEHDIFPDNYTRREIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEK 204
            ..:.||....|    .|..|:.|.:|:..|.|:..||.|            :||...::..| :.
Human    67 RKEVKRKKVVH----MNKLRKTIGRLEVKCKNADAGCIV------------TCPLAHRKGHQ-DS 114

  Fly   205 CPFAKIKCDFVGRPETNQLEEHLKADMPHHMQLMLQAFQQTAI----ATWQPHKPSTSGA--AVE 263
            |||....|...|.  |:|:.....|:...|.|   |..||...    ||..|.:.:....  .:.
Human   115 CPFELTACPNEGC--TSQVPRGTLAEHRQHCQ---QGSQQRCPLGCGATLDPAERARHNCYRELH 174

  Fly   264 NGHGQQQLPPPPQYANGVDEQIVQTMYQRIVVLEQRT---REQETRLENMQKQLRLARQQAP 322
            |....:|....|         ::.::.:|:..|:|.|   |.:...|.|..::.....:.||
Human   175 NAWSVRQERRRP---------LLLSLLRRVRWLDQATSVVRRELAELSNFLEEDTALLEGAP 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	14/39 (36%)
		Sina	163..>230	CDD:302762	16/66 (24%)
		MATH_TRAF6	330..473	CDD:239745
RNF151	XP_005255186.1	RING	29..70	CDD:238093	14/40 (35%)
RNF151	XP_005255186.1	Sina	92..>139	CDD:302762	16/61 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D918518at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820