DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Traf6 and traf1

DIOPT Version :9

Sequence 1:NP_511080.2 Gene:Traf6 / 31746 FlyBaseID:FBgn0265464 Length:475 Species:Drosophila melanogaster
Sequence 2:XP_031747100.1 Gene:traf1 / 101734662 XenbaseID:XB-GENE-22069371 Length:549 Species:Xenopus tropicalis


Alignment Length:502 Identity:109/502 - (21%)
Similarity:179/502 - (35%) Gaps:177/502 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 APGSDTSGEQEEELLDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCP-------- 140
            |||             .:|.|..|.:.|.:...|.||||:|..||...:.:|:..||        
 Frog    33 APG-------------EKYLCCSCKNVLKKAQQTLCGHRYCTPCLVWIVSRNHDLCPKCKAEDPT 84

  Fly   141 -MDNKRLSAEHDIFPDNYTRREIEQLKRDC---------------PNSSL----------GCSVV 179
             :.:..|..|...|.|....:||.:||..|               .:.||          ||...
 Frog    85 TLSDDSLLKEERAFSDAAINKEISELKVHCVIPGCTWRGLMRDYEEHESLCNYALIPCHTGCGHR 149

  Fly   180 ASPIELHRHLPS--------CP-------------YRRQQEP----------------------Q 201
            ....:|..||.|        ||             :|.::.|                      :
 Frog   150 VMRKQLADHLESECPNNTIKCPKCTQHFSSNEFPKHRCEKGPTDDQSHRKTDQSAKGKNGNSHSK 214

  Fly   202 EEKCPFAKIKCDFVGRPETNQLEEHLKADMPHHMQL---MLQAFQQTAIAT-------WQPHKPS 256
            :|||.|..:.|.:||..|  :::||.:.....|:.|   ::...:.....|       :.|...|
 Frog   215 KEKCHFTPLGCTYVGSRE--KIKEHYRTSAAAHLSLVCPLILRIKDNLTNTEGKKNGFYVPLADS 277

  Fly   257 TSGAAVEN-----------GHGQQQL-------PPPPQYAN---------GVDEQIVQTMYQRI- 293
            |.|...:|           |:|..:|       .|..:.||         .|.|.|:..:.:.| 
 Frog   278 TDGPGQKNPFSLQAEDFKAGNGDLELDCGHAVGQPSDEVANRLSLLETRLQVFENIISVLSKEID 342

  Fly   294 -------VVLEQRTREQ------ETRLENMQKQL--------RLARQQAPVDPRYSNGTIVWRIE 337
                   .:.||:..|:      |.::||::..|        .|..:.|.::....:|..:|:|.
 Frog   343 SSQSQLAAIKEQKAEEERKVKALEHKVENLRCTLAMKDIVLNELEMRSACLEQTSYDGVFLWKIS 407

  Fly   338 QL-----GALVARLRANANNQVYSHECYTSPHGYKFCARLNIQ----PRKPHVLSLHVHLMQSEN 393
            .|     .|:..|..:     :||...||:.:|||.|.|:.:.    .:..|| ||...:|:.|.
 Frog   408 DLTNKSHDAVTGRAIS-----LYSPAFYTAKYGYKVCLRIYLNGDGAGKGTHV-SLFFTVMKGEY 466

  Fly   394 DYHLDWPFKGRIKLCMV-HPADATLSQHDTIMT--KPEI--LAFHKP 435
            |..|.||||.::...:| |      :..|::..  :|::  .:|.:|
 Frog   467 DALLPWPFKHKVTFVLVDH------NNRDSVFDAFRPDVTSASFQRP 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Traf6NP_511080.2 RING 103..141 CDD:238093 14/46 (30%)
Sina 163..>230 CDD:302762 25/134 (19%)
MATH_TRAF6 330..473 CDD:239745 33/120 (28%)
traf1XP_031747100.1 RING_Ubox 38..79 CDD:418438 15/40 (38%)
RAD18 39..>214 CDD:227719 35/174 (20%)
TRAF_BIRC3_bd 317..377 CDD:406958 12/59 (20%)
MATH 400..546 CDD:351761 33/120 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D391991at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.010

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