DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Traf6 and pdzrn3b

DIOPT Version :9

Sequence 1:	NP_511080.2	Gene:	Traf6 / 31746	FlyBaseID:	FBgn0265464	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001243321.1	Gene:	pdzrn3b / 100005518	ZFINID:	ZDB-GENE-071022-4	Length:	1053	Species:	Danio rerio

Alignment Length:	231	Identity:	52/231 - (22%)
Similarity:	94/231 - (40%)	Gaps:	46/231 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 LDSRYECAICIDWLNEPVLTSCGHRFCRSCLTAWMQKNNQCCPMDNKRLSAE--HDIFPDNYTRR 160
            :|..::|.:|...|.:|:.|.|||.||..|:..|:.:.:. ||:..:|:|.:  :.:.|   .:.
Zfish    12 VDPDFKCNLCNKVLEDPLTTPCGHVFCAGCVLPWVVQQSS-CPVKCQRISTKELNHVLP---LKN 72

  Fly   161 EIEQLKRDCPNSSLGCSVVASPIELHRHLPSCPYRRQQEPQEEKCPFAKIKCDFVGRPETNQLEE 225
            .|.:|...|.|.:.||..:.....|..|             .|.|.::..||...|..|...|:
Zfish    73 LILKLDIKCDNHARGCEKIVKLQHLAEH-------------AEMCDYSPAKCRNKGCSEVLNLK- 123

  Fly   226 HLKADMPHHMQLMLQAFQQTAIATWQPHKPSTSGAAVENGHGQQQLP-----PPPQYANGVDEQI 285
                ||..||:   ::....|:...:      ||..:...|.:.:|.     ...:..||
Zfish   124 ----DMDAHMR---ESCDYRAVGICE------SGCGLMLTHKEHKLDNHCCLKALKAHNG----- 170

  Fly   286 VQTMYQRIVVLEQRTREQETRLENMQKQLRLARQQA 321
              .:..::|.|::..::|..:....:|.| ||:..|
Zfish   171 --ALQGKVVTLDKELKKQALKSTKREKSL-LAQLSA 203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Traf6	NP_511080.2	RING	103..141	CDD:238093	13/37 (35%)
		Sina	163..>230	CDD:302762	14/66 (21%)
		MATH_TRAF6	330..473	CDD:239745
pdzrn3b	NP_001243321.1	RING	17..58	CDD:238093	14/41 (34%)
		PDZ	245..337	CDD:214570
		PDZ_signaling	421..489	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	563..604
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	747..855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0297
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810