DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18262 and ZNF630

DIOPT Version :9

Sequence 1:	NP_572453.1	Gene:	CG18262 / 31745	FlyBaseID:	FBgn0030012	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_001032824.2	Gene:	ZNF630 / 57232	HGNCID:	28855	Length:	657	Species:	Homo sapiens

Alignment Length:	537	Identity:	132/537 - (24%)
Similarity:	195/537 - (36%)	Gaps:	137/537 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 PDVAGGYHN---LRCGEVLFSAPASYEVSCLLCDQRLPLDGYPEH------FRLKHFTNSSSSLC 63
            ||...|..:   :..||:||              ||..|:..|:.      .::.|..|......
Human    79 PDRVKGLESSQQIISGELLF--------------QREILERAPKDNSLYSVLKIWHIDNQMDRYQ 129

  Fly    64 SNELESDPIAQDVVEVQGNEELHEELAKEAS---------PDL----------EEEEEEKEEGSK 109
            .|:   |.:.:.|. |...|.|.:|:..:.|         .||          :..|...:..|.
Human   130 GNQ---DRVLRQVT-VISRETLTDEMGSKYSAFGKMFNRCTDLAPLSQKFHKFDSCENSLKSNSD 190

  Fly   110 RQHYQRAAAMKNTL----------------VETREDLLDIELDWTGGEQSEHNETHEEEEGESDD 158
            ..:|.|:.|.||..                |..:|..:...::..|..|.|...:|::...:...
Human   191 LLNYNRSYARKNPTKRFRCGRPPKYNASCSVPEKEGFIHTGMEPYGDSQCEKVLSHKQAHVQYKK 255

  Fly   159 DDTKDSNDTKDMLFQCDQCDRAYNTKRSLQSHRRLKHSEAN--GGSLDKSASERN---------- 211
            ...::..:.      |..|.:|:..|..|..|:|:...|..  .|...|:.||::
Human   256 FQAREKPNV------CSMCGKAFIKKSQLIIHQRIHTGEKPYVCGDCRKAFSEKSHLIVHQRIHT 314

  Fly   212 ------------SKKRKGP----------PKVYKCNE--------------------------EA 228
                        :..||.|          .|.|:|.|                          ..
Human   315 GEKPYECTKYGRAFSRKSPFTVHQRVHTGEKPYECFECPKAFSQKSHLIIHQRVHTREKPFECSE 379

  Fly   229 CNQTFRTERDLRGHRWKHTG---IFCDICGKPFTQSGNMMRHRQRHSGIKPHKCPECDATFYTQK 290
            |.:.|.....|..|:..|||   ..|..|||.|.:...::.|::.|:|.||:||.||..||..|.
Human   380 CRKAFCEMSHLFIHQITHTGKKPYECTECGKTFPRKTQLIIHQRTHTGEKPYKCGECGKTFCQQS 444

  Fly   291 ELSSHSICHTGRMPCICEVCGRPCRDRGVLTAHMRRHTGERPAKCEVCGKAFYSFHDLNVHAVSH 355
            .|..|...|||..|.:|..||:....:..||.|.|.||||:|..|..|||:|.....|.:|...|
Human   445 HLIGHQRIHTGEKPYVCTDCGKAFSQKSHLTGHQRLHTGEKPYMCTECGKSFSQKSPLIIHQRIH 509

  Fly   356 TNLRPFVCDVCGSTFQRKKALRVHKLLHSEQRKYACKLCGKTFAQSGGLNAHMRSHDPARVKGAV 420
            |..:|:.|..||.||.:|..|.:|..:|:.::.|.|..||:.|:....|..|.|.|.      ..
Human   510 TGEKPYQCGECGKTFSQKSLLIIHLRVHTGEKPYECTECGRAFSLKSHLILHQRGHT------GE 568

  Fly   421 KPLPQSVTIEVIEGKSP 437
            ||...|...:...||||
Human   569 KPYECSECGKAFCGKSP 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18262	NP_572453.1	C2H2 Zn finger	224..246	CDD:275368	6/47 (13%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		COG5048	<256..415	CDD:227381	60/158 (38%)
		zf-H2C2_2	263..288	CDD:290200	11/24 (46%)
		C2H2 Zn finger	279..327	CDD:275368	19/47 (40%)
		zf-H2C2_2	320..342	CDD:290200	13/21 (62%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	8/19 (42%)
		zf-C2H2	389..411	CDD:278523	8/21 (38%)
		C2H2 Zn finger	391..411	CDD:275368	7/19 (37%)
ZNF630	NP_001032824.2	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	238..257	CDD:275368	3/18 (17%)
		C2H2 Zn finger	265..285	CDD:275368	7/19 (37%)
		C2H2 Zn finger	293..313	CDD:275368	4/19 (21%)
		zf-H2C2_2	305..330	CDD:290200	0/24 (0%)
		C2H2 Zn finger	321..341	CDD:275368	3/19 (16%)
		COG5048	<329..578	CDD:227381	80/254 (31%)
		zf-H2C2_2	336..358	CDD:290200	4/21 (19%)
		C2H2 Zn finger	349..369	CDD:275368	2/19 (11%)
		C2H2 Zn finger	377..397	CDD:275368	4/19 (21%)
		zf-H2C2_2	389..412	CDD:290200	9/22 (41%)
		C2H2 Zn finger	405..425	CDD:275368	6/19 (32%)
		zf-H2C2_2	418..440	CDD:290200	9/21 (43%)
		C2H2 Zn finger	433..453	CDD:275368	8/19 (42%)
		zf-H2C2_2	449..470	CDD:290200	8/20 (40%)
		C2H2 Zn finger	461..481	CDD:275368	7/19 (37%)
		zf-H2C2_2	473..498	CDD:290200	14/24 (58%)
		C2H2 Zn finger	489..509	CDD:275368	7/19 (37%)
		zf-H2C2_2	502..526	CDD:290200	10/23 (43%)
		C2H2 Zn finger	517..537	CDD:275368	8/19 (42%)
		zf-H2C2_2	530..553	CDD:290200	7/22 (32%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		zf-H2C2_2	557..580	CDD:290200	7/28 (25%)
		C2H2 Zn finger	573..593	CDD:275368	5/13 (38%)
		C2H2 Zn finger	601..620	CDD:275370
		C2H2 Zn finger	629..646	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000