Protein Alignment CG18262 and ZNF724

DIOPT Version :10

• Sequence 1: NP_572453.1
• Gene: CG18262 / 31745
• FlyBaseID: FBgn0030012
• Length: 469
• Species: Drosophila melanogaster
• Sequence 2: NP_001342333.1
• Gene: ZNF724 / 440519
• HGNCID: 32460
• Length: 619
• Species: Homo sapiens
• Alignment Length: 516
• Identity: 134/516 - (25%)
• Similarity: 205/516 - (39%)
• Gaps: 127/516 - (24%)

  Fly    13 GYHNLRCGEVLFSAPASYEV---------SCLLCDQR--LPLDGYPEHFRL-----KHFTNSSSS 61
            |:|||:..:. :.:...|:|         .||...|.  ...|.|.:.|..     :|.|..:..
Human   107 GHHNLQLKKG-YKSVDEYKVHKGSYNGFNQCLTTTQSKIFQCDKYVKDFHKFSNSNRHKTEKNPF 170

  Fly    62 LCSNELESDPIAQDVVEVQGNEELH--------EELAK--EASPDLEEEEEEKEEGSKRQHYQ-- 114
            .|....:|..:...:.:   ::.:|        ||..|  ..|..|   .:.|...:.::||:
Human   171 KCKECGKSFCVLSHLTQ---HKRIHTTVNSYKLEECGKAFNVSSTL---SQHKRIHTGQKHYKCE 229

  Fly   115 ------RAAAMKNT--LVETREDLLDIELDWTGGEQSEHNETHE-----------EEEGESDDDD 160
                  ..::..||  ::.|.|.....|........|.|..||:           :|.|::.:..
Human   230 ECGIAFNKSSHLNTHKIIHTGEKSYKREECGKAFNISSHLTTHKIIHTGENAYKCKECGKAFNQS 294

  Fly   161 T-------------------------KDSNDTK-------DMLFQCDQCDRAYNTKRSLQSHRRL 193
            :                         :.||.||       |..::|::|.:|:|...:|..|:|:
Human   295 STLTRHKIIHAGEKPYICEHCGRAFNQSSNLTKHKRIHTGDKPYKCEECGKAFNVSSTLTQHKRI 359

  Fly   194 KHS-------EANGGSLDKSASERNSKKRKGPPKVYKCNEEACNQTFRTERDLRGHRWKHTG--- 248
             |:       |..|.:.:.|::....|:.....|.|||.|  |.:.|.|...|..|:..|||
Human   360 -HTGEKPYKCEECGKAFNVSSTLTQHKRIHTGEKPYKCEE--CGKAFNTSSHLTTHKRIHTGEKP 421

  Fly   249 IFCDICGKPFTQSGNMMRHRQRHSGIKPHKCPECDATFYTQKELSSHSICHTGRMPCICEVCGR- 312
            ..|:.|||.|.|...:..|:..|:|.||:||.||...|.....|:.|.|.|||..|..||.||:
Human   422 YKCEECGKAFNQFSQLTTHKIIHTGEKPYKCKECGKAFKRSSNLTEHRIIHTGEKPYKCEECGKA 486

  Fly   313 --------------------PCRDRG-------VLTAHMRRHTGERPAKCEVCGKAFYSFHDLNV 350
                                .|::.|       .|..|...|.||:|.|||.||||||.:.:|..
Human   487 FNLSSHLTTHKKIHTGEKPYKCKECGKAFNQSSTLARHKIIHAGEKPYKCEECGKAFYQYSNLTQ 551

  Fly   351 HAVSHTNLRPFVCDVCGSTFQRKKALRVHKLLHSEQRKYACKLCGKTFAQSGGLNAHMRSH 411
            |.:.||..:|:.|:.||..|.....|..||::|:.::.|.||.|||.|.|...|..|.:.|
Human   552 HKIIHTGEKPYKCEECGKAFNWSSTLTKHKVIHTGEKPYKCKECGKAFNQCSNLTTHKKIH 612

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG18262	NP_572453.1	COG5236	<222..>313	CDD:227561	39/114 (34%)
		C2H2 Zn finger	224..246	CDD:275368	7/21 (33%)
		C2H2 Zn finger	251..271	CDD:275368	7/19 (37%)
		zf-H2C2_2	263..288	CDD:463886	10/24 (42%)
		C2H2 Zn finger	279..327	CDD:275368	19/75 (25%)
		zf-H2C2_2	320..342	CDD:463886	12/21 (57%)
		C2H2 Zn finger	335..355	CDD:275368	10/19 (53%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		zf-C2H2	389..411	CDD:395048	10/21 (48%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
ZNF724	NP_001342333.1	KRAB	4..64	CDD:214630
		COG5048	143..526	CDD:227381	88/391 (23%)
		C2H2 Zn finger	172..192	CDD:275368	2/22 (9%)
		C2H2 Zn finger	201..220	CDD:275368	6/21 (29%)
		C2H2 Zn finger	228..248	CDD:275368	2/19 (11%)
		C2H2 Zn finger	257..276	CDD:275368	5/18 (28%)
		C2H2 Zn finger	284..304	CDD:275368	2/19 (11%)
		C2H2 Zn finger	312..332	CDD:275368	4/19 (21%)
		C2H2 Zn finger	340..360	CDD:275368	7/20 (35%)
		C2H2 Zn finger	368..388	CDD:275368	4/19 (21%)
		C2H2 Zn finger	396..416	CDD:275368	7/21 (33%)
		C2H2 Zn finger	424..444	CDD:275368	7/19 (37%)
		C2H2 Zn finger	452..472	CDD:275368	7/19 (37%)
		C2H2 Zn finger	480..500	CDD:275368	4/19 (21%)
		C2H2 Zn finger	508..528	CDD:275368	4/19 (21%)
		zf-H2C2_2	521..545	CDD:463886	14/23 (61%)
		C2H2 Zn finger	536..556	CDD:275368	10/19 (53%)
		zf-H2C2_2	548..572	CDD:463886	8/23 (35%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		zf-H2C2_2	577..601	CDD:463886	11/23 (48%)
		C2H2 Zn finger	592..612	CDD:275368	9/19 (47%)