DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18262 and CG8319

DIOPT Version :9

Sequence 1:	NP_572453.1	Gene:	CG18262 / 31745	FlyBaseID:	FBgn0030012	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_649920.2	Gene:	CG8319 / 41165	FlyBaseID:	FBgn0037722	Length:	383	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	80/338 - (23%)
Similarity:	130/338 - (38%)	Gaps:	79/338 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 LESDPIAQDVVEVQ----GNEELHEELAKEASPDLEEEEEEKEEGSKRQHYQRAAAMKNTLVETR 127
            ::.:|..:|.:.::    ||.|..::|.||.               |:.|...:...|:::..:|
  Fly    89 IKDEPNEEDFLFIENPDKGNLEAKKKLNKEI---------------KKTHQTASRTTKSSITTSR 138

  Fly   128 EDLLDIELDWTGGEQSEHNETHEEEEGESDDDDTKDSNDTKDMLFQCDQCDRAYNTKRSLQSHRR 192
                       .|.|                     ....|:..|:|:.|.:.:..:.:|..|.:
  Fly   139 -----------AGRQ---------------------LRSIKNQTFKCELCIKQFKRQINLLDHMK 171

  Fly   193 LKHSEAN-----------GGSLDKSASERNSKKRKGPPKVYKCNEEACNQTFRTERDLRGHRWK- 245
            : ||.::           ...||.....|||.      ...:|.|  |.:.|.:.:.|..|:.|
  Fly   172 V-HSNSHVCQNCEERFLFKADLDNHQCYRNSN------STVECPE--CLKVFSSTQSLDSHKCKD 227

  Fly   246 ---HTGIFCDICGKPFTQSGNMMRHRQRHS----GIKPHKCPECDATFYTQKELSSHSICHTGRM 303
               .:...|..|.:.||:..|:..|...|:    |..||||..|...|:.:..|..|...|.|..
  Fly   228 MQERSPFQCPHCQQAFTREQNLKAHLLIHAESKQGNGPHKCSYCQTGFFNKSALKVHIHAHMGER 292

  Fly   304 PCICEVCGRPCRDRGVLTAHMRRHTGERPAKCEVCGKAFYSFHDLNVHAVSHTNLRPFVCDVCGS 368
            |..|..|....|.:..|..|:|.||||:|.:|..|.|.|...::|..|...|::.||:.|.:|..
  Fly   293 PHACPFCVSNFRSKQALKVHIRIHTGEKPYQCPHCPKTFSDNNNLAKHRRRHSDERPYKCSICLQ 357

  Fly   369 TFQRKKALRVHKL 381
            .|:.|..|:.|.|
  Fly   358 DFREKHHLKRHFL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18262	NP_572453.1	C2H2 Zn finger	224..246	CDD:275368	7/25 (28%)
		C2H2 Zn finger	251..271	CDD:275368	6/19 (32%)
		COG5048	<256..415	CDD:227381	44/130 (34%)
		zf-H2C2_2	263..288	CDD:290200	10/28 (36%)
		C2H2 Zn finger	279..327	CDD:275368	14/47 (30%)
		zf-H2C2_2	320..342	CDD:290200	11/21 (52%)
		C2H2 Zn finger	335..355	CDD:275368	6/19 (32%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		zf-C2H2	389..411	CDD:278523
		C2H2 Zn finger	391..411	CDD:275368
CG8319	NP_649920.2	zf-AD	4..79	CDD:285071
		COG5048	<153..368	CDD:227381	62/223 (28%)
		C2H2 Zn finger	153..173	CDD:275368	4/20 (20%)
		C2H2 Zn finger	179..196	CDD:275368	2/16 (13%)
		C2H2 Zn finger	207..227	CDD:275370	6/21 (29%)
		C2H2 Zn finger	236..256	CDD:275368	6/19 (32%)
		C2H2 Zn finger	268..288	CDD:275368	5/19 (26%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		zf-H2C2_2	308..332	CDD:290200	11/23 (48%)
		zf-C2H2	322..344	CDD:278523	6/21 (29%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		C2H2 Zn finger	352..368	CDD:275368	5/15 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45449794
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030