DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18262 and ZNF710

DIOPT Version :9

Sequence 1:	NP_572453.1	Gene:	CG18262 / 31745	FlyBaseID:	FBgn0030012	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	XP_005254963.1	Gene:	ZNF710 / 374655	HGNCID:	25352	Length:	679	Species:	Homo sapiens

Alignment Length:	449	Identity:	117/449 - (26%)
Similarity:	166/449 - (36%)	Gaps:	120/449 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 FSAPASYEVSCLLCDQRLPLDGYPEHFRLKHFTNSSSSLCSNELESDPIAQDVVEVQGNEELH-E 87
            |.|||.              ||:||         .|.:|        |..:.:....|.|..| .
Human   191 FPAPAR--------------DGFPE---------PSMAL--------PGPEALPTECGFEPPHLA 224

  Fly    88 ELAKEASPDLEEEEEEK-EEGSKRQHYQRAAAMKNTLVETREDLLDIELDWTGGEQSEHNETHEE 151
            .|:...:|.:|..|..| |:|..   :|.|:              :.|.|..|.....|.:...:
Human   225 PLSDPEAPSMESPEPVKPEQGFV---WQEAS--------------EFEADTAGSTVERHKKAQLD 272

  Fly   152 E---EGESDDDDTKDSNDTKDMLFQCDQCDRAYNTKRSLQSHRRLKHSEANGGSLDKSASERNSK 213
            .   ..:.||....::.| :...:||..|:::|.:|.:|.:| .|.|   ||
Human   273 RLDINVQIDDSYLVEAGD-RQKRWQCRMCEKSYTSKYNLVTH-ILGH---NG------------- 319

  Fly   214 KRKGPPKVYKCNEEACNQTFRTERDLRGHRWKHTGI---FCDICGKPFTQSGNMMRHRQRHSGIK 275
                 .|.:.|..  |::.|:....|:.|...|.|.   .|.:|.|.|||:.::.||...||.:|
Human   320 -----IKPHSCPH--CSKLFKQPSHLQTHLLTHQGTRPHKCQVCHKAFTQTSHLKRHMLLHSEVK 377

  Fly   276 P----------------------------HKCPECDATFYTQKELSSHSICHTGRMPCICEVCGR 312
            |                            |.|.||...|.|..:|..|...|.|.....|..|.:
Human   378 PYSCHFCGRGFAYPSELKAHEVKHESGRCHVCVECGLDFSTLTQLKRHLASHQGPTLYQCLECDK 442

  Fly   313 PCRDRGVLTAHMRRHTGERPAKCEVCGKAFYSFHDLNVHAVSHTNLRPFVCDVCGSTFQRKKALR 377
            ....|..|..||.:|...||..|..||..|...|.|..|:::|..::.|.|:|||..|..:..::
Human   443 SFHYRSQLQNHMLKHQNVRPFVCTECGMEFSQIHHLKQHSLTHKGVKEFKCEVCGREFTLQANMK 507

  Fly   378 VHKLLHSEQRKYACKLCGKTFAQSGGLNAHMRSHDPARVKGAVKPLPQSVTIEVIEGKS 436
            .|.|:|:..|.|.|.:|.|||.|...|..||..|.|      |||....|.     |||
Human   508 RHMLIHTSVRPYQCHICFKTFVQKQTLKTHMIVHSP------VKPFKCKVC-----GKS 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18262	NP_572453.1	C2H2 Zn finger	224..246	CDD:275368	5/21 (24%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		COG5048	<256..415	CDD:227381	59/186 (32%)
		zf-H2C2_2	263..288	CDD:290200	11/52 (21%)
		C2H2 Zn finger	279..327	CDD:275368	15/47 (32%)
		zf-H2C2_2	320..342	CDD:290200	9/21 (43%)
		C2H2 Zn finger	335..355	CDD:275368	7/19 (37%)
		C2H2 Zn finger	363..383	CDD:275368	7/19 (37%)
		zf-C2H2	389..411	CDD:278523	10/21 (48%)
		C2H2 Zn finger	391..411	CDD:275368	9/19 (47%)
ZNF710	XP_005254963.1	C2H2 Zn finger	297..317	CDD:275368	7/20 (35%)
		C2H2 Zn finger	325..345	CDD:275368	5/21 (24%)
		COG5048	<335..593	CDD:227381	72/232 (31%)
		zf-H2C2_2	337..362	CDD:290200	8/24 (33%)
		C2H2 Zn finger	353..373	CDD:275368	8/19 (42%)
		zf-H2C2_2	365..390	CDD:290200	6/24 (25%)
		C2H2 Zn finger	381..401	CDD:275368	0/19 (0%)
		C2H2 Zn finger	409..429	CDD:275368	7/19 (37%)
		zf-C2H2	435..457	CDD:278523	6/21 (29%)
		C2H2 Zn finger	437..457	CDD:275368	6/19 (32%)
		zf-H2C2_2	450..474	CDD:290200	10/23 (43%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..513	CDD:275368	7/19 (37%)
		zf-H2C2_2	505..530	CDD:290200	10/24 (42%)
		C2H2 Zn finger	521..541	CDD:275368	9/19 (47%)
		zf-H2C2_2	534..558	CDD:290200	12/33 (36%)
		C2H2 Zn finger	549..569	CDD:275368	4/12 (33%)
		C2H2 Zn finger	577..596	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910