DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG18262 and ZNF366

DIOPT Version :9

Sequence 1:	NP_572453.1	Gene:	CG18262 / 31745	FlyBaseID:	FBgn0030012	Length:	469	Species:	Drosophila melanogaster
Sequence 2:	NP_689838.1	Gene:	ZNF366 / 167465	HGNCID:	18316	Length:	744	Species:	Homo sapiens

Alignment Length:	391	Identity:	91/391 - (23%)
Similarity:	141/391 - (36%)	Gaps:	136/391 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 LAKEASPDLEEEEEEKEEGSKRQHYQRAAAMKNTLVETREDLLDIELDWT-----GGEQSEHNET 148
            |.::|.|...||.::|.|                    |.| :::::|.:     ||.|..
Human   213 LPRKAEPQESEETKQKVE--------------------RVD-VNVQIDDSYYVDVGGSQKR---- 252

  Fly   149 HEEEEGESDDDDTKDSNDTKDMLFQCDQCDRAYNTKRSLQSHRRLKHSEANGGSLDKSASERNSK 213
                                   :||..|:::|.:|.:|.:| .|.||..
Human   253 -----------------------WQCPTCEKSYTSKYNLVTH-ILGHSGI--------------- 278

  Fly   214 KRKGPPKVYKCNEEACNQTFRTERDLRGHRWKHTGI---FCDICGKPFTQSGNMMRHRQRHSGIK 275
                  |.:.|..  |.:.|:....|..|...|.|.   .|.:|.|.|||:.::.||..:||.:|
Human   279 ------KPHACTH--CGKLFKQLSHLHTHMLTHQGTRPHKCQVCHKAFTQTSHLKRHMMQHSEVK 335

  Fly   276 PH--------------------------------------------------------KCPECDA 284
            ||                                                        .|.|||.
Human   336 PHNCRVCGRGFAYPSELKAHEAKHASGRENICVECGLDFPTLAQLKRHLTTHRGPIQYNCSECDK 400

  Fly   285 TFYTQKELSSHSICHTGRMPCICEVCGRPCRDRGVLTAHMRRHTGERPAKCEVCGKAFYSFHDLN 349
            ||....:|.:|.:.|....|.||..||........|..|...|.|.:..||.:||:.|....::.
Human   401 TFQYPSQLQNHMMKHKDIRPYICSECGMEFVQPHHLKQHSLTHKGVKEHKCGICGREFTLLANMK 465

  Fly   350 VHAVSHTNLRPFVCDVCGSTFQRKKALRVHKLLHSEQRKYACKLCGKTFAQSGGLNAHMRSHDPA 414
            .|.:.|||:|.:.|.:|..:|.:|:.|:.|.::||:.:.:.||||||.|.:...|..||..|..:
Human   466 RHVLIHTNIRAYQCHLCYKSFVQKQTLKAHMIVHSDVKPFKCKLCGKEFNRMHNLMGHMHLHSDS 530

  Fly   415 R 415
            :
Human   531 K 531

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG18262	NP_572453.1	C2H2 Zn finger	224..246	CDD:275368	5/21 (24%)
		C2H2 Zn finger	251..271	CDD:275368	8/19 (42%)
		COG5048	<256..415	CDD:227381	58/214 (27%)
		zf-H2C2_2	263..288	CDD:290200	13/80 (16%)
		C2H2 Zn finger	279..327	CDD:275368	16/47 (34%)
		zf-H2C2_2	320..342	CDD:290200	8/21 (38%)
		C2H2 Zn finger	335..355	CDD:275368	5/19 (26%)
		C2H2 Zn finger	363..383	CDD:275368	6/19 (32%)
		zf-C2H2	389..411	CDD:278523	10/21 (48%)
		C2H2 Zn finger	391..411	CDD:275368	10/19 (53%)
ZNF366	NP_689838.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..228		5/14 (36%)
		COG5048	253..>549	CDD:227381	78/303 (26%)
		C2H2 Zn finger	255..275	CDD:275368	7/20 (35%)
		C2H2 Zn finger	283..303	CDD:275368	5/21 (24%)
		C2H2 Zn finger	311..331	CDD:275368	8/19 (42%)
		C2H2 Zn finger	339..359	CDD:275368	0/19 (0%)
		C2H2 Zn finger	367..387	CDD:275368	0/19 (0%)
		C2H2 Zn finger	395..415	CDD:275368	8/19 (42%)
		C2H2 Zn finger	423..443	CDD:275368	5/19 (26%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		Interaction with NRIP1. /evidence=ECO:0000269\|PubMed:17085477	455..744		26/77 (34%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	10/19 (53%)
		C2H2 Zn finger	535..554	CDD:275368
		PXDLS. /evidence=ECO:0000269\|PubMed:16393996, ECO:0000269\|PubMed:17085477	590..594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	603..627
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	664..692
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910