DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta5 and gnb2

DIOPT Version :9

Sequence 1:	NP_572452.1	Gene:	Gbeta5 / 31744	FlyBaseID:	FBgn0030011	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	XP_005165361.1	Gene:	gnb2 / 541370	ZFINID:	ZDB-GENE-050320-65	Length:	344	Species:	Danio rerio

Alignment Length:	344	Identity:	163/344 - (47%)
Similarity:	239/344 - (69%)	Gaps:	7/344 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 KMASLVREAENLKTKLEEERQKLNDVNLSNIAERLEQIAYVNIKPRKVLKGHQAKVLCTDWSPDK 82
            ::..|.:|||.|:.::.:.|:...|..|:.|...|:.:..:.::.|:.|:||.||:....|..|.
Zfish     3 ELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67

  Fly    83 RHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPITSDEEM 147
            |.::|:||||:|||||::||||.||:.:.::|:|.|||||||||||||||||..::|.:.:.|..
Zfish    68 RLLVSASQDGKLIIWDSYTTNKIHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTREGN 132

  Fly   148 AAKKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLAPNE 212
            ....|.:..||.|:|||.:.: |.||:|.|||:||||||:|:||....|.|||||||::.|||:
Zfish   133 VRVSRELPGHTGYLSCCRFID-DNQIITSSGDTTCALWDIETGQQTTLFSGHSGDVMSLSLAPD- 195

  Fly   213 TGNTFVSGSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMRADR 277
             ..||:||:||....:||:|.....|:|.||:||:|:..|.|.|.|.||||||::|||:|:|||:
Zfish   196 -SRTFISGACDASIKLWDIRDSMCRQTFTGHESDINAACFFPSGSAFATGSDDATCRLFDLRADQ 259

  Fly   278 EVAVFAKESIIFGVNSVDFSVSGRLLFAGYNDYTVNLWDTLKSER----VCLLYGHENKVSCVQV 338
            |:.:::.::||.|:.||.||.|||||.|||:|:..|:||.:|.||    ..:|.||:|:|||:.|
Zfish   260 ELCLYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGERAGKHTGVLAGHDNRVSCLGV 324

  Fly   339 SPDGTALSTGSWDYTIRVW 357
            :.||.|:.|||||..:::|
Zfish   325 TDDGMAVCTGSWDSFLKIW 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta5	NP_572452.1	WD40	62..358	CDD:238121	153/300 (51%)
		WD40 repeat	73..110	CDD:293791	19/36 (53%)
		WD40 repeat	116..156	CDD:293791	21/39 (54%)
		WD40 repeat	161..197	CDD:293791	19/35 (54%)
		WD40 repeat	204..241	CDD:293791	14/36 (39%)
		WD40 repeat	247..283	CDD:293791	19/35 (54%)
		WD40 repeat	291..327	CDD:293791	19/39 (49%)
		WD40 repeat	333..357	CDD:293791	12/23 (52%)
gnb2	XP_005165361.1	WD40	48..344	CDD:238121	153/299 (51%)
		WD40	<49..344	CDD:225201	152/298 (51%)
		WD40 repeat	58..95	CDD:293791	19/36 (53%)
		WD40 repeat	101..141	CDD:293791	21/39 (54%)
		WD40 repeat	146..181	CDD:293791	19/35 (54%)
		WD40 repeat	188..223	CDD:293791	14/36 (39%)
		WD40 repeat	229..265	CDD:293791	19/35 (54%)
		WD40 repeat	273..313	CDD:293791	19/39 (49%)
		WD40 repeat	319..343	CDD:293791	12/23 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.820