DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta5 and Gbeta76C

DIOPT Version :9

Sequence 1:	NP_572452.1	Gene:	Gbeta5 / 31744	FlyBaseID:	FBgn0030011	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster

Alignment Length:	346	Identity:	128/346 - (36%)
Similarity:	203/346 - (58%)	Gaps:	12/346 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TEKMASLVREAENLKTKLEEERQKLNDVNLSNIAERLEQIAYVNIKPRKVLKGHQAKVLCTDWSP 80
            |:|   |..|...:..|.:::::...|..|::....:..:..:....:|:||||..||....::.
  Fly     8 TQK---LYDEINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVHFAG 69

  Fly    81 DKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPITS-D 144
            |.||.::.|.||:|||||.:|.||...:.:.:.|:|..|::||||||||||:||:.|||.:.: |
  Fly    70 DSRHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVNNRD 134

  Fly   145 EEMAAK--KRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAID 207
            ....||  |..:| :..::|.|.:.: |..::|||||.....||:|.|.....|:||:||:..:.
  Fly   135 ASGVAKMVKELMG-YEGFLSSCRFLD-DGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLS 197

  Fly   208 LAPNETGNTFVSGSCDRMAFIWDMR-SGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLY 271
            |:|:.  .|:::||.|:.|.:||:| .|| .|.|.||..||:||.:||.|...|:.|:|.:.|:|
  Fly   198 LSPDM--KTYITGSVDKTAKLWDVREEGH-KQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARMY 259

  Fly   272 DMRADREVAVFAKESIIFGVNSVDFSVSGRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCV 336
            |:|||:::|.:.......|..|...|.|||.|..|..:..|:.|||:|......|.||||:::|:
  Fly   260 DLRADQQIAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITCI 324

  Fly   337 QVSPDGTALSTGSWDYTIRVW 357
            .:.|:|..|::.|||..:|:|
  Fly   325 SLCPNGMCLASTSWDQQVRLW 345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta5	NP_572452.1	WD40	62..358	CDD:238121	121/300 (40%)
		WD40 repeat	73..110	CDD:293791	15/36 (42%)
		WD40 repeat	116..156	CDD:293791	21/42 (50%)
		WD40 repeat	161..197	CDD:293791	12/35 (34%)
		WD40 repeat	204..241	CDD:293791	13/37 (35%)
		WD40 repeat	247..283	CDD:293791	16/35 (46%)
		WD40 repeat	291..327	CDD:293791	12/35 (34%)
		WD40 repeat	333..357	CDD:293791	8/23 (35%)
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	120/304 (39%)
		WD40	51..345	CDD:238121	120/298 (40%)
		WD40 repeat	64..99	CDD:293791	14/34 (41%)
		WD40 repeat	105..147	CDD:293791	21/41 (51%)
		WD40 repeat	152..187	CDD:293791	12/35 (34%)
		WD40 repeat	194..229	CDD:293791	13/37 (35%)
		WD40 repeat	235..271	CDD:293791	16/35 (46%)
		WD40 repeat	279..315	CDD:293791	12/35 (34%)
		WD40 repeat	321..345	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468720
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	304	1.000	Inparanoid score	I767
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		otm46827
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
	9	8.900