DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta5 and gnb5b

DIOPT Version :9

Sequence 1:	NP_572452.1	Gene:	Gbeta5 / 31744	FlyBaseID:	FBgn0030011	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_957040.1	Gene:	gnb5b / 393719	ZFINID:	ZDB-GENE-040426-1712	Length:	395	Species:	Danio rerio

Alignment Length:	344	Identity:	230/344 - (66%)
Similarity:	285/344 - (82%)	Gaps:	2/344 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EKMASLVREAENLKTKLEEERQKLNDVNLSNIAERLEQIAYVNIKPRKVLKGHQAKVLCTDWSPD 81
            |.:.||..|:|:||.||||||.||:||.|..:||::|.:....:|.|:.||||..||||.||..|
Zfish    52 ETVQSLKAESESLKAKLEEERAKLHDVELHQVAEKMEALGQFVMKTRRTLKGHGNKVLCMDWCRD 116

  Fly    82 KRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPITSD-- 144
            ||.|:||||||::|:|||:|||||||||||.||:|||||||||..|||||||||.:|||::.|
Zfish   117 KRRIVSSSQDGKVIVWDAYTTNKEHAVTMPCTWVMACAYAPSGCAVACGGLDNKCSVYPLSLDKN 181

  Fly   145 EEMAAKKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLA 209
            |.:|:||::|..||:|:|.|.:..||.||||.|||.||||||||||||||||||||.||:::|||
Zfish   182 ENLASKKKSVAMHTNYLSSCSFTKSDMQILTSSGDGTCALWDVESGQLLQSFHGHSADVLSLDLA 246

  Fly   210 PNETGNTFVSGSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMR 274
            |:|||:|||||.||:.|.:||||||..|||||.|.||:||||::|.|||.|:||||::|||||:|
Zfish   247 PSETGSTFVSGGCDKKANVWDMRSGQNVQSFETHDSDINSVKYYPSGDAFASGSDDATCRLYDLR 311

  Fly   275 ADREVAVFAKESIIFGVNSVDFSVSGRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVS 339
            ||||||:::|:|||||.:|||||:||||||||||||.:|:||.||..||.:|:||||:||.|:||
Zfish   312 ADREVAIYSKDSIIFGASSVDFSLSGRLLFAGYNDYNINVWDVLKGTRVAILFGHENRVSTVRVS 376

  Fly   340 PDGTALSTGSWDYTIRVWA 358
            |||||..:||||.|:|:||
Zfish   377 PDGTAFCSGSWDNTLRIWA 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta5	NP_572452.1	WD40	62..358	CDD:238121	206/297 (69%)
		WD40 repeat	73..110	CDD:293791	27/36 (75%)
		WD40 repeat	116..156	CDD:293791	27/41 (66%)
		WD40 repeat	161..197	CDD:293791	26/35 (74%)
		WD40 repeat	204..241	CDD:293791	24/36 (67%)
		WD40 repeat	247..283	CDD:293791	25/35 (71%)
		WD40 repeat	291..327	CDD:293791	24/35 (69%)
		WD40 repeat	333..357	CDD:293791	16/23 (70%)
gnb5b	NP_957040.1	WD40	98..395	CDD:238121	206/296 (70%)
		WD 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	103..142		27/38 (71%)
		WD40 repeat	108..145	CDD:293791	27/36 (75%)
		WD 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	145..184		27/38 (71%)
		WD40 repeat	151..193	CDD:293791	27/41 (66%)
		WD 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	193..234		29/40 (73%)
		WD40 repeat	198..234	CDD:293791	26/35 (74%)
		WD 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	235..276		27/40 (68%)
		WD40 repeat	241..278	CDD:293791	24/36 (67%)
		WD 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	279..318		27/38 (71%)
		WD40 repeat	284..320	CDD:293791	25/35 (71%)
		WD 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	320..362		30/41 (73%)
		WD40 repeat	328..364	CDD:293791	24/35 (69%)
		WD 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221	365..395		20/29 (69%)
		WD40 repeat	370..394	CDD:293791	16/23 (70%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594726
Domainoid	1	1.000	89	1.000	Domainoid score	I7831
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40714
Inparanoid	1	1.050	505	1.000	Inparanoid score	I1305
OMA	1	1.010	-	-		QHG48070
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		otm24785
orthoMCL	1	0.900	-	-		OOG6_107558
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770