DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta5 and gpb-2

DIOPT Version :9

Sequence 1:	NP_572452.1	Gene:	Gbeta5 / 31744	FlyBaseID:	FBgn0030011	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_492072.2	Gene:	gpb-2 / 172483	WormBaseID:	WBGene00001680	Length:	369	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	218/361 - (60%)
Similarity:	285/361 - (78%)	Gaps:	5/361 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SEAAVPASNANANATEK----MASLVREAENLKTKLEEERQKLNDVNLSNIAERLEQIAYVNIKP 62
            |.:.:| .|:....|||    :..|..|||.|:.||::||.||||:.:...||||:.:..:.:|.
Worm    10 SSSKMP-ENSQPTTTEKGSEYLEQLANEAEELRKKLDQERHKLNDIPIQQAAERLDVMGALGVKQ 73

  Fly    63 RKVLKGHQAKVLCTDWSPDKRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFV 127
            |::||||..||||.|||.|||||:||||||::|:||.||||||||:||||||:||||::||...:
Worm    74 RRILKGHVGKVLCMDWSLDKRHIVSSSQDGKVIVWDGFTTNKEHALTMPTTWVMACAFSPSSQMI 138

  Fly   128 ACGGLDNKVTVYPITSDEEMAAKKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQL 192
            ||||||||.:|.|::.::::..|||.|.|||||||||.:..||..|||||||||||:||||||||
Worm   139 ACGGLDNKCSVVPLSFEDDIIQKKRQVATHTSYMSCCTFLRSDNLILTGSGDSTCAIWDVESGQL 203

  Fly   193 LQSFHGHSGDVMAIDLAPNETGNTFVSGSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGD 257
            :|:||||:|||.|||:...:|||||:|...|:.:.:||:|||..|||||||::|:|:|:|||.||
Worm   204 IQNFHGHTGDVFAIDVPKCDTGNTFISAGADKHSLVWDIRSGQCVQSFEGHEADINTVRFHPNGD 268

  Fly   258 AIATGSDDSSCRLYDMRADREVAVFAKESIIFGVNSVDFSVSGRLLFAGYNDYTVNLWDTLKSER 322
            |.||||||::|||:|:||||:|.|:.||||:|.||.||||:|||:|||||.||.|.:||:||..|
Worm   269 AFATGSDDATCRLFDLRADRQVCVYEKESILFPVNGVDFSLSGRILFAGYGDYRVGVWDSLKCAR 333

  Fly   323 VCLLYGHENKVSCVQVSPDGTALSTGSWDYTIRVWA 358
            ..:||||||::||::.||||||:.:.|||.|||:||
Worm   334 HSVLYGHENRISCLRTSPDGTAVCSASWDCTIRIWA 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta5	NP_572452.1	WD40	62..358	CDD:238121	192/295 (65%)
		WD40 repeat	73..110	CDD:293791	28/36 (78%)
		WD40 repeat	116..156	CDD:293791	20/39 (51%)
		WD40 repeat	161..197	CDD:293791	26/35 (74%)
		WD40 repeat	204..241	CDD:293791	18/36 (50%)
		WD40 repeat	247..283	CDD:293791	24/35 (69%)
		WD40 repeat	291..327	CDD:293791	22/35 (63%)
		WD40 repeat	333..357	CDD:293791	14/23 (61%)
gpb-2	NP_492072.2	WD40	74..369	CDD:238121	192/294 (65%)
		WD40 repeat	84..121	CDD:293791	28/36 (78%)
		WD40 repeat	127..167	CDD:293791	20/39 (51%)
		WD40 repeat	172..208	CDD:293791	26/35 (74%)
		WD40 repeat	215..252	CDD:293791	18/36 (50%)
		WD40 repeat	258..294	CDD:293791	24/35 (69%)
		WD40 repeat	302..338	CDD:293791	22/35 (63%)
		WD40 repeat	344..368	CDD:293791	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166302
Domainoid	1	1.000	42	1.000	Domainoid score	I8453
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40714
Inparanoid	1	1.050	485	1.000	Inparanoid score	I792
Isobase	1	0.950	-	0	Normalized mean entropy	S614
OMA	1	1.010	-	-		QHG48070
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		oto18546
orthoMCL	1	0.900	-	-		OOG6_107558
Panther	1	1.100	-	-	LDO	PTHR19850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2536
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790