DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta5 and GNB5

DIOPT Version :9

Sequence 1:	NP_572452.1	Gene:	Gbeta5 / 31744	FlyBaseID:	FBgn0030011	Length:	358	Species:	Drosophila melanogaster
Sequence 2:	NP_057278.2	Gene:	GNB5 / 10681	HGNCID:	4401	Length:	395	Species:	Homo sapiens

Alignment Length:	344	Identity:	236/344 - (68%)
Similarity:	288/344 - (83%)	Gaps:	2/344 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 EKMASLVREAENLKTKLEEERQKLNDVNLSNIAERLEQIAYVNIKPRKVLKGHQAKVLCTDWSPD 81
            |.:|||..|||:||.||||||.||:||.|..:|||:|.:....:|.|:.||||..||||.||..|
Human    52 ETLASLKSEAESLKGKLEEERAKLHDVELHQVAERVEALGQFVMKTRRTLKGHGNKVLCMDWCKD 116

  Fly    82 KRHIISSSQDGRLIIWDAFTTNKEHAVTMPTTWIMACAYAPSGNFVACGGLDNKVTVYPITSD-- 144
            ||.|:||||||::|:||:||||||||||||.||:|||||||||..:||||||||.:|||:|.|
Human   117 KRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLTFDKN 181

  Fly   145 EEMAAKKRTVGTHTSYMSCCIYPNSDQQILTGSGDSTCALWDVESGQLLQSFHGHSGDVMAIDLA 209
            |.|||||::|..||:|:|.|.:.|||.||||.|||.|||||||||||||||||||..||:.:|||
Human   182 ENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLCLDLA 246

  Fly   210 PNETGNTFVSGSCDRMAFIWDMRSGHVVQSFEGHQSDVNSVKFHPCGDAIATGSDDSSCRLYDMR 274
            |:|||||||||.||:.|.:||||||..||:||.|:||:|||:::|.|||.|:||||::|||||:|
Human   247 PSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRLYDLR 311

  Fly   275 ADREVAVFAKESIIFGVNSVDFSVSGRLLFAGYNDYTVNLWDTLKSERVCLLYGHENKVSCVQVS 339
            ||||||:::|||||||.:|||||:|||||||||||||:|:||.||..||.:|:||||:||.::||
Human   312 ADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVS 376

  Fly   340 PDGTALSTGSWDYTIRVWA 358
            |||||..:||||:|:||||
Human   377 PDGTAFCSGSWDHTLRVWA 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta5	NP_572452.1	WD40	62..358	CDD:238121	209/297 (70%)
		WD40 repeat	73..110	CDD:293791	27/36 (75%)
		WD40 repeat	116..156	CDD:293791	29/41 (71%)
		WD40 repeat	161..197	CDD:293791	27/35 (77%)
		WD40 repeat	204..241	CDD:293791	24/36 (67%)
		WD40 repeat	247..283	CDD:293791	24/35 (69%)
		WD40 repeat	291..327	CDD:293791	25/35 (71%)
		WD40 repeat	333..357	CDD:293791	15/23 (65%)
GNB5	NP_057278.2	WD40	98..395	CDD:238121	209/296 (71%)
		WD 1	103..142		27/38 (71%)
		WD40 repeat	108..145	CDD:293791	27/36 (75%)
		WD 2	145..184		27/38 (71%)
		WD40 repeat	151..193	CDD:293791	29/41 (71%)
		WD 3	193..234		30/40 (75%)
		WD40 repeat	198..234	CDD:293791	27/35 (77%)
		WD 4	236..278		27/41 (66%)
		WD40 repeat	241..278	CDD:293791	24/36 (67%)
		WD 5	279..318		26/38 (68%)
		WD40 repeat	284..320	CDD:293791	24/35 (69%)
		WD 6	320..362		32/41 (78%)
		WD40 repeat	328..364	CDD:293791	25/35 (71%)
		WD 7	365..394		19/28 (68%)
		WD40 repeat	370..394	CDD:293791	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158788
Domainoid	1	1.000	90	1.000	Domainoid score	I7795
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H40714
Inparanoid	1	1.050	512	1.000	Inparanoid score	I1318
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48070
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		oto90320
orthoMCL	1	0.900	-	-		OOG6_107558
Panther	1	1.100	-	-	LDO	PTHR19850
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2536
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800