DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10959 and CRZ1

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_014371.1	Gene:	CRZ1 / 855704	SGDID:	S000004972	Length:	678	Species:	Saccharomyces cerevisiae

Alignment Length:	368	Identity:	76/368 - (20%)
Similarity:	133/368 - (36%)	Gaps:	102/368 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 NVDYVRLHAQQQLRPKCGEIFYEPEANRFQLVCLLCDMKHFGFEDFARHIRNVHFDKQGRPLTKT 72
            |..|...:....|||...:  |..||        |.|:.. .|||.... |.:...|..|..::|
Yeast   360 NESYSATNNNNLLRPDDND--YNNEA--------LSDIDR-SFEDIING-RKLKLKKSRRRSSQT 412

  Fly    73 VTGLGRLAREEQEFQGVSAEPLA--VDSFKKEYLPNEDVL-SEEEDAEQE--------------- 119
             :.....:|.....:.:|.:..|  :.:.:::.|...|:| |.|.|..:|
Yeast   413 -SNNSFTSRRSSRSRSISPDEKAKSISANREKLLEMADLLPSSENDNNRERYDNDSKTSYNTINS 476

  Fly   120 LGLEQDEGN--------PLRIMVLGGKQSVDEETIDTMWQPDHDSSSASVNEGCALEALLGVENP 176
            ....:|..|        .:...::..|..:|:.:.|.....|.||..       ..|..:|.:|.
Yeast   477 SNFNEDNNNNNLLTSKPKIESGIVNIKNELDDTSKDLGILLDIDSLG-------QFEQKVGFKND 534

  Fly   177 QDYQPDEDGEEHQSVFKKQRQPKDYNCPHCDRRYTTQKYLNTHLKMSHPFPQAFKCVDCKATFDV 241
            .:::.:::|                       .::.:|  |.:|:                  .:
Yeast   535 DNHENNDNG-----------------------TFSVKK--NDNLE------------------KL 556

  Fly   242 DRALAQHRRKEHTEFACQLCDKVFKSSRSLLRHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRR 306
            |.  ..:.||....|||.:|.|.|....:|..|::.|:..|.|.|  ..|||:|..||:...|..
Yeast   557 DS--VTNNRKNPANFACDVCGKKFTRPYNLKSHLRTHTNERPFIC--SICGKAFARQHDRKRHED 617

  Fly   307 VHSEERNYVC--EL-------CGYRSRYREALIVHRRTHTGEK 340
            :|:.::.|||  :|       ||.:....:||..|.:|.:|.:
Yeast   618 LHTGKKRYVCGGKLKDGKPWGCGKKFARSDALGRHFKTESGRR 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	3/20 (15%)
		COG5048	<258..416	CDD:227381	29/92 (32%)
		C2H2 Zn finger	258..278	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	316..336	CDD:275368	7/28 (25%)
		zf-H2C2_2	328..353	CDD:290200	5/13 (38%)
		C2H2 Zn finger	344..364	CDD:275368
		zf-H2C2_2	357..381	CDD:290200
		C2H2 Zn finger	372..392	CDD:275368
		C2H2 Zn finger	400..420	CDD:275368
CRZ1	NP_014371.1	COG5048	139..617	CDD:227381	64/323 (20%)
		C2H2 Zn finger	571..591	CDD:275368	6/19 (32%)
		C2H2 Zn finger	599..619	CDD:275368	8/21 (38%)
		C2H2 Zn finger	627..655	CDD:275368	7/27 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100