DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10959 and ZSCAN10

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_116194.2	Gene:	ZSCAN10 / 84891	HGNCID:	12997	Length:	780	Species:	Homo sapiens

Alignment Length:	437	Identity:	110/437 - (25%)
Similarity:	172/437 - (39%)	Gaps:	126/437 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRHCLANVDYVRLHAQQQLRPKCGEIFYEPEANRFQLVCLLCDMKHFG--FE---DFARHIRNV 60
            :::|.||       |||.| :|.|..   |.:|....|..:||  .|.|  |:   ...||:| :
Human   447 LVQHLLA-------HAQDQ-KPPCAP---ESKAEAPPLTDVLC--SHCGQSFQRRSSLKRHLR-I 497

  Fly    61 HFDKQGRPLTKTVTGLGRLAREEQEFQGVSAEPLAVDSFKKEYLPNEDVLSEEEDAEQELGLEQD 125
            |                  ||:                  |:...:|...|...|:::...:..|
Human   498 H------------------ARD------------------KDRRSSEGSGSRRRDSDRRPFVCSD 526

  Fly   126 EGNPLRIMVLGGKQSVDEETIDTMWQPDHDSSSASVNEGCALEALLGVENPQDYQPDEDGEEHQS 190
            .|...|                   :.:|..:...|:.|         |.|
Human   527 CGKAFR-------------------RSEHLVAHRRVHTG---------ERP-------------- 549

  Fly   191 VFKKQRQPKDYNCPHCDRRYTTQKYLNTHLKMSHPFPQAFKCVDCKATFDVDRALAQH------R 249
                      ::|..|.|.:|....|.:|.:: |...:.:.|..|...|....:||:|      .
Human   550 ----------FSCQACGRSFTQSSQLVSHQRV-HTGEKPYACPQCGKRFVRRASLARHLLTHGGP 603

  Fly   250 RKEHTEFACQLCDKVFKSSRSLLRHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNY 314
            |..|    |..|.|.|..::.|.||.:.|:|.:..:|  ..||:.|....:|..|:|:|:.|:.:
Human   604 RPHH----CTQCGKSFGQTQDLARHQRSHTGEKPCRC--SECGEGFSQSAHLARHQRIHTGEKPH 662

  Fly   315 VCELCGYRSRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHS------TEKPYKCD 373
            .|:.||:|.|....|..|||:||||:|:.||||.|.|...:.|..|.|.|:      .|.|.:|.
Human   663 ACDTCGHRFRNSSNLARHRRSHTGERPYSCQTCGRSFRRNAHLRRHLATHAEPGQEQAEPPQECV 727

  Fly   374 KCDSAFSRPKALYHHKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAH 420
            :|..:|||...|..|..:|.|.:.:.|..||.::::.:.|..|:|.|
Human   728 ECGKSFSRSCNLLRHLLVHTGARPYSCTQCGRSFSRNSHLLRHLRTH 774

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	7/26 (27%)
		COG5048	<258..416	CDD:227381	57/163 (35%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	316..336	CDD:275368	9/19 (47%)
		zf-H2C2_2	328..353	CDD:290200	15/24 (63%)
		C2H2 Zn finger	344..364	CDD:275368	9/19 (47%)
		zf-H2C2_2	357..381	CDD:290200	9/29 (31%)
		C2H2 Zn finger	372..392	CDD:275368	7/19 (37%)
		C2H2 Zn finger	400..420	CDD:275368	6/19 (32%)
ZSCAN10	NP_116194.2	SCAN	40..124	CDD:153421
		PHA03418	156..>314	CDD:177646
		C2H2 Zn finger	349..370	CDD:275368
		C2H2 Zn finger	378..398	CDD:275368
		zf-H2C2_2	391..415	CDD:290200
		COG5048	400..774	CDD:227381	109/435 (25%)
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368	3/13 (23%)
		C2H2 Zn finger	478..498	CDD:275368	7/22 (32%)
		zf-C2H2	522..544	CDD:278523	4/40 (10%)
		C2H2 Zn finger	524..544	CDD:275368	4/38 (11%)
		zf-H2C2_2	536..561	CDD:290200	8/57 (14%)
		C2H2 Zn finger	552..572	CDD:275368	6/20 (30%)
		zf-H2C2_2	565..589	CDD:290200	6/24 (25%)
		C2H2 Zn finger	580..600	CDD:275368	6/19 (32%)
		zf-H2C2_2	592..615	CDD:290200	8/26 (31%)
		C2H2 Zn finger	608..628	CDD:275368	7/19 (37%)
		zf-H2C2_2	620..645	CDD:290200	9/26 (35%)
		C2H2 Zn finger	636..656	CDD:275368	7/21 (33%)
		zf-H2C2_2	648..673	CDD:290200	9/24 (38%)
		C2H2 Zn finger	664..684	CDD:275368	9/19 (47%)
		zf-H2C2_2	676..701	CDD:290200	15/24 (63%)
		C2H2 Zn finger	692..712	CDD:275368	9/19 (47%)
		C2H2 Zn finger	728..746	CDD:275368	6/17 (35%)
		zf-H2C2_2	738..763	CDD:290200	7/24 (29%)
		zf-C2H2	752..774	CDD:278523	6/21 (29%)
		C2H2 Zn finger	754..774	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910