DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10959 and ZBTB17

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001274532.1	Gene:	ZBTB17 / 7709	HGNCID:	12936	Length:	810	Species:	Homo sapiens

Alignment Length:	428	Identity:	115/428 - (26%)
Similarity:	177/428 - (41%)	Gaps:	96/428 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 DKQGRPLTKTVTGLGRLAREEQEFQGVSA--------------EPLAVDSFKKEYLPNEDVLSEE 113
            ::.||   .|..|..|..:||:..|..||              ||..|: .|.:  |...:.:.|
Human   151 EQAGR---STPIGPSRDLKEERGGQAQSAASGAEQTEKADAPREPPPVE-LKPD--PTSGMAAAE 209

  Fly   114 ------EDAEQELGLEQDEGNPLRIMVLGGKQSVDEETIDTMWQPDHDSSSASV-NEGCALEALL 171
                  |.:|||:.:|     |.|   .|.::..::|.     |.:..:..|.| .||..||
Human   210 AEAALSESSEQEMEVE-----PAR---KGEEEQKEQEE-----QEEEGAGPAEVKEEGSQLE--- 258

  Fly   172 GVENPQDYQPDE-----DGEE--------HQSVFKKQRQPKDY-----NCPHCDRRYTTQKYLNT 218
            ..|.|::.:.:|     .|:|        ....:..:.:.|.|     .|..|.:.:|.......
Human   259 NGEAPEENENEESAGTDSGQELGSEARGLRSGTYGDRTESKAYGSVIHKCEDCGKEFTHTGNFKR 323

  Fly   219 HLKMSHPFPQAFKCVDCKATFDVDRALAQHRRKEHT---EFACQLCDKVFKSSRSLLRHVQGHSG 280
            |::: |...:.|.|.:|...|. |.|..:...|.|:   .:.|:.|.|.::....|..|.:.|||
Human   324 HIRI-HTGEKPFSCRECSKAFS-DPAACKAHEKTHSPLKPYGCEECGKSYRLISLLNLHKKRHSG 386

  Fly   281 ARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCG-------YRSRYREA---------- 328
            ...::|  |:|||.|....||..|:.|||.|:.|.|:.||       .:.|:.|.
Human   387 EARYRC--EDCGKLFTTSGNLKRHQLVHSGEKPYQCDYCGRSFSDPTSKMRHLETHDTDKEHKCP 449

  Fly   329 -----------LIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSRP 382
                       |..|.:.|..:.|.:|:.|.::|.:...|..|..:||.||||.|..|...|:.|
Human   450 HCDKKFNQVGNLKAHLKIHIADGPLKCRECGKQFTTSGNLKRHLRIHSGEKPYVCIHCQRQFADP 514

  Fly   383 KALYHHKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAH 420
            .||..|..:|.|.|..:|.:||.|:.||:.|.||:|.|
Human   515 GALQRHVRIHTGEKPCQCVMCGKAFTQASSLIAHVRQH 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	6/20 (30%)
		COG5048	<258..416	CDD:227381	59/185 (32%)
		C2H2 Zn finger	258..278	CDD:275368	5/19 (26%)
		C2H2 Zn finger	289..308	CDD:275368	8/18 (44%)
		C2H2 Zn finger	316..336	CDD:275368	7/47 (15%)
		zf-H2C2_2	328..353	CDD:290200	7/45 (16%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..381	CDD:290200	11/23 (48%)
		C2H2 Zn finger	372..392	CDD:275368	7/19 (37%)
		C2H2 Zn finger	400..420	CDD:275368	10/19 (53%)
ZBTB17	NP_001274532.1	BTB	14..109	CDD:279045
		BTB	25..109	CDD:197585
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	116..295		37/165 (22%)
		Interaction with MYC	269..308		5/38 (13%)
		COG5048	306..637	CDD:227381	76/251 (30%)
		zf-C2H2	306..328	CDD:278523	4/22 (18%)
		C2H2 Zn finger	308..328	CDD:275368	4/20 (20%)
		zf-H2C2_2	320..344	CDD:290200	5/24 (21%)
		C2H2 Zn finger	336..356	CDD:275368	6/20 (30%)
		C2H2 Zn finger	364..384	CDD:275368	5/19 (26%)
		zf-C2H2	390..412	CDD:278523	9/23 (39%)
		C2H2 Zn finger	392..412	CDD:275368	9/21 (43%)
		zf-H2C2_2	404..428	CDD:290200	11/23 (48%)
		C2H2 Zn finger	420..440	CDD:275368	5/19 (26%)
		zf-C2H2	446..468	CDD:278523	2/21 (10%)
		C2H2 Zn finger	448..468	CDD:275368	2/19 (11%)
		zf-C2H2	475..496	CDD:278523	5/20 (25%)
		C2H2 Zn finger	476..496	CDD:275368	5/19 (26%)
		zf-H2C2_2	488..512	CDD:290200	10/23 (43%)
		C2H2 Zn finger	504..524	CDD:275368	7/19 (37%)
		zf-H2C2_2	516..541	CDD:290200	10/24 (42%)
		C2H2 Zn finger	532..552	CDD:275368	10/19 (53%)
		zf-H2C2_2	544..569	CDD:290200	5/9 (56%)
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	573..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	600..625	CDD:290200
		C2H2 Zn finger	616..635	CDD:275370
		C2H2 Zn finger	726..746	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	786..810
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000