DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10959 and ZBTB16

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001018011.1	Gene:	ZBTB16 / 7704	HGNCID:	12930	Length:	673	Species:	Homo sapiens

Alignment Length:	269	Identity:	87/269 - (32%)
Similarity:	130/269 - (48%)	Gaps:	15/269 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 SSSASVNEGCALEALLGVENPQDYQPDEDGEEHQSVFKKQRQPKDYNCPHCDRRYTTQKYLNTHL 220
            |.|.::.|.|   ::.|||.|.    :|..|:|:   |.....|.|.|..|.:|:.....|..||
Human   397 SESRTIGEQC---SVCGVELPD----NEAVEQHR---KLHSGMKTYGCELCGKRFLDSLRLRMHL 451

  Fly   221 KMSHPFPQAFKCVDCKATFDVDRALAQHRRKE-HTEFA--CQLCDKVFKSSRSLLRHVQGHSGAR 282
            .......:||.|..|.|.|..:.||..||:.. .|:.|  |.||.|.|::..:|.:|::.|:|.|
Human   452 LAHSAGAKAFVCDQCGAQFSKEDALETHRQTHTGTDMAVFCLLCGKRFQAQSALQQHMEVHAGVR 516

  Fly   283 TFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYRSRYREALIVHRRTHTGEKPFQCQTC 347
            ::.|  ..|.::|.:...|..|.|.|:.:..|.||.||...|....|..|:|.||||||::|..|
Human   517 SYIC--SECNRTFPSHTALKRHLRSHTGDHPYECEFCGSCFRDESTLKSHKRIHTGEKPYECNGC 579

  Fly   348 ARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSRPKALYHHKHLHLGIKKFKCKICGNAYAQAAG 412
            .::|:.|..|..|..:|:.|||::|..|........|:..|...|.|...::|.||.......:.
Human   580 GKKFSLKHQLETHYRVHTGEKPFECKLCHQRSRDYSAMIKHLRTHNGASPYQCTICTEYCPSLSS 644

  Fly   413 LSAHMRAHK 421
            :..||:.||
Human   645 MQKHMKGHK 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	8/21 (38%)
		COG5048	<258..416	CDD:227381	51/157 (32%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		C2H2 Zn finger	289..308	CDD:275368	5/18 (28%)
		C2H2 Zn finger	316..336	CDD:275368	8/19 (42%)
		zf-H2C2_2	328..353	CDD:290200	12/24 (50%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		zf-H2C2_2	357..381	CDD:290200	8/23 (35%)
		C2H2 Zn finger	372..392	CDD:275368	4/19 (21%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
ZBTB16	NP_001018011.1	BTB	25..125	CDD:306997
		Herpes_ICP4_C	177..>327	CDD:332854
		Interaction with RUNX1T1. /evidence=ECO:0000269\|PubMed:10688654	200..300
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	215..236
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..332
		C2H2 Zn finger	406..426	CDD:275368	9/29 (31%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		COG5048	<448..622	CDD:227381	60/175 (34%)
		C2H2 Zn finger	463..483	CDD:275368	8/19 (42%)
		C2H2 Zn finger	492..512	CDD:275368	7/19 (37%)
		C2H2 Zn finger	520..540	CDD:275368	6/21 (29%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		C2H2 Zn finger	576..596	CDD:275368	6/19 (32%)
		C2H2 Zn finger	604..624	CDD:275368	4/19 (21%)
		C2H2 Zn finger	632..652	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910