DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10959 and Hic2

DIOPT Version :9

Sequence 1:NP_572451.1 Gene:CG10959 / 31743 FlyBaseID:FBgn0030010 Length:443 Species:Drosophila melanogaster
Sequence 2:NP_849253.2 Gene:Hic2 / 58180 MGIID:1929869 Length:619 Species:Mus musculus


Alignment Length:386 Identity:89/386 - (23%)
Similarity:131/386 - (33%) Gaps:121/386 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 EQELGLEQDEGNPLRIMVLGGKQSVDEETI---DTMWQPDHDSSSASV---NEGCALEALLGVEN 175
            ||||||:..:.:|.......|.....|:..   |:..:....:|::::   |....:|.....|.
Mouse   241 EQELGLDLSKKSPPLPPTTPGPHLTPEDPAQLSDSQRESPAPTSTSALPVGNSASFVELGATPEE 305

  Fly   176 PQDYQPDEDGEEHQSVFKKQ-RQP----------KDYN--------------------CPHCDRR 209
            |.|.:..|  |.|.|:.:.| .||          ||:|                    ||..:..
Mouse   306 PMDVEGAE--ENHLSLLEGQGGQPRKSLRHSARKKDWNKKEPVAGSPFDRRETGSKGSCPGEEGE 368

  Fly   210 YTTQKYLNTHLKMS------------HPFPQAFKCVDCKATFDVDRALAQHRRKEHTE------- 255
            .|..:..|..|..|            ..||       ||...:..:..::...:..:|       
Mouse   369 GTGDRVPNGVLASSAGGGGPSASYGEQSFP-------CKEEEENGKDGSEDSGQSGSEGGSGHTG 426

  Fly   256 -------------------FACQLCDKVFKSSRSLLRHVQGH----------------SG----- 280
                               :.|..|.|.|.||..|..||:.|                ||     
Mouse   427 AHYVYRQEGYETVSYGDNVYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAEEE 491

  Fly   281 --------------ARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYRSRYREALIV 331
                          :|.|||  ..|.|::.:...|..|.:.|...|.:.|.:||.....|..:..
Mouse   492 AEDLSTPSAAYTADSRPFKC--SVCEKTYKDPATLRQHEKTHWLTRPFPCNICGKMFTQRGTMTR 554

  Fly   332 HRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSRPKALYHHKHLH 392
            |.|:|.|.|||.|..|..||..:..|.||..:||.||||:|..|...|::.:.|..|..:|
Mouse   555 HMRSHLGLKPFACDECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMH 615

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10959NP_572451.1 C2H2 Zn finger 232..253 CDD:275368 2/20 (10%)
COG5048 <258..416 CDD:227381 52/170 (31%)
C2H2 Zn finger 258..278 CDD:275368 9/19 (47%)
C2H2 Zn finger 289..308 CDD:275368 4/18 (22%)
C2H2 Zn finger 316..336 CDD:275368 6/19 (32%)
zf-H2C2_2 328..353 CDD:290200 11/24 (46%)
C2H2 Zn finger 344..364 CDD:275368 7/19 (37%)
zf-H2C2_2 357..381 CDD:290200 12/23 (52%)
C2H2 Zn finger 372..392 CDD:275368 5/19 (26%)
C2H2 Zn finger 400..420 CDD:275368
Hic2NP_849253.2 BTB 40..140 CDD:279045
BTB 47..141 CDD:197585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 180..293 11/51 (22%)
Binding to CtBP. /evidence=ECO:0000250 247..249 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 307..426 22/127 (17%)
C2H2 Zn finger 448..468 CDD:275368 9/19 (47%)
zf-C2H2 509..531 CDD:278523 7/23 (30%)
C2H2 Zn finger 511..531 CDD:275368 5/21 (24%)
zf-C2H2 537..559 CDD:278523 6/21 (29%)
C2H2 Zn finger 539..559 CDD:275368 6/19 (32%)
zf-H2C2_2 552..576 CDD:290200 11/23 (48%)
COG5048 563..>617 CDD:227381 22/53 (42%)
C2H2 Zn finger 567..587 CDD:275368 7/19 (37%)
zf-H2C2_2 580..604 CDD:290200 12/23 (52%)
C2H2 Zn finger 595..615 CDD:275368 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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