Protein Alignment CG10959 and ZBTB4

DIOPT Version :10

• Sequence 1: NP_572451.1
• Gene: CG10959 / 31743
• FlyBaseID: FBgn0030010
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_065950.2
• Gene: ZBTB4 / 57659
• HGNCID: 23847
• Length: 1013
• Species: Homo sapiens
• Alignment Length: 355
• Identity: 78/355 - (21%)
• Similarity: 114/355 - (32%)
• Gaps: 112/355 - (31%)

  Fly   128 NPLRIMVLGG-KQSVDEETIDTMWQ-----PDHDSSSASVNEGCALEALLGVENPQDY------- 179
            :|.|::.|.| ..:...:.::.::.     |......|:|.|..||...||:...|..
Human   121 SPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGALGRRLGISRLQGLGEGGDAW 185

  Fly   180 -----------QPDED---------GEEHQSVFKKQ---------RQPKDYNCPHCDRRYTTQKY 215
                       ||:||         ||......:.|         |:|  ..||.|.:.:...|.
Human   186 VPPTPAPMATSQPEEDSFGPGPRPAGEWEGDRAEAQAPDLQCSLPRRP--LPCPQCGKSFIHPKR 248

  Fly   216 LNTH---------------LKMSHPFPQAFKCVDCKAT-----FDVDRALAQHRRK---EHTEFA 257
            |.||               |......|.....||..|.     |   |...:|..|   .|..:.
Human   249 LQTHEAQCRRGASTRGSTGLGAGGAGPGGPAGVDASALPPPVGF---RGGPEHVVKVVGGHVLYV 310

  Fly   258 CQLCDKVFKSSRSLLRHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYR 322
            |..|::.:.:..||.||...||..|.:.|.:  |.|.|.                     |..||
Human   311 CAACERSYVTLSSLKRHSNVHSWRRKYPCRY--CEKVFA---------------------LAEYR 352

  Fly   323 SRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQ-AMHSTEKP-YKCDKCDSAFSRPK-- 383
            ::       |...||||:.:||..|...|.:...|..|| |.|..... ...:|..:...:||
Human   353 TK-------HEVWHTGERRYQCIFCWETFVTYYNLKTHQRAFHGISPGLLASEKTPNGGYKPKLN 410

  Fly   384 --ALYHHKHLHLGIKKFKCKICGNAYAQAA 411
              .||....:....:.:|      .|:|.|
Human   411 TLKLYRLLPMRAAKRPYK------TYSQGA 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	7/28 (25%)
		COG5048	<258..416	CDD:227381	39/160 (24%)
		C2H2 Zn finger	258..278	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..308	CDD:275368	3/18 (17%)
		C2H2 Zn finger	316..336	CDD:275368	4/19 (21%)
		C2H2 Zn finger	344..364	CDD:275368	7/20 (35%)
		C2H2 Zn finger	372..392	CDD:275368	5/23 (22%)
		C2H2 Zn finger	400..420	CDD:275368	3/12 (25%)
ZBTB4	NP_065950.2	BTB_POZ	12..181	CDD:453885	13/59 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	67..124		1/2 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	183..221		6/37 (16%)
		Interaction with CBFA2T3. /evidence=ECO:0000269|PubMed:23251453	186..348		39/189 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	257..281		2/23 (9%)
		C2H2 Zn finger	311..331	CDD:275368	6/19 (32%)
		C2H2 Zn finger	339..359	CDD:275368	8/49 (16%)
		C2H2 Zn finger	367..385	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	428..765		4/13 (31%)
		C2H2 Zn finger	728..748	CDD:275368
		zf-C2H2	765..787	CDD:395048
		C2H2 Zn finger	767..787	CDD:275368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	783..852
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	883..904
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	972..1013