Protein Alignment CG10959 and Plag1

DIOPT Version :10

• Sequence 1: NP_572451.1
• Gene: CG10959 / 31743
• FlyBaseID: FBgn0030010
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_064353.2
• Gene: Plag1 / 56711
• MGIID: 1891916
• Length: 499
• Species: Mus musculus
• Alignment Length: 252
• Identity: 67/252 - (26%)
• Similarity: 104/252 - (41%)
• Gaps: 47/252 - (18%)

  Fly   234 DCKATFDVDRALAQHRR----KEHTEFACQLCDKVFKSSRSLLRHVQGHSGARTFKCEHENCGKS 294
            |.....|..:|.:..|:    |....|.||||||.|.|...|..|...|:|.|.:||.|::|.|:
Mouse     8 DLSEVRDTQKAPSGKRKRGESKPRKNFPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCTKA 72

  Fly   295 FVNQHNLTSHRRVHSEERNYVCELCGYRSRYREALIVHRRTHTGEK-PFQCQTCARRFASKSLLN 358
            ||:::.|..|...||.|:.:.|..|......::.|..|..||...| .|:|:.|.:.:.:|....
Mouse    73 FVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFK 137

  Fly   359 EHQAMHST------------------------------------EKPYKCDKCDSAFSRPKALYH 387
            .|.|:|:.                                    ||.::|:.|:..|...|.:..
Mouse   138 RHLALHAATSGDLTCKVCLQNFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCERRFYTRKDVRR 202

  Fly   388 HKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAHKLQASVNATEGAEAEPIEML--FT 442
            |..:|.|.|.|.|:.|...:.:...|:.||:....|..:.    .:.||::.|  ||
Mouse   203 HMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLK----VKTEPVDFLDPFT 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	5/22 (23%)
		COG5048	<258..416	CDD:227381	53/194 (27%)
		C2H2 Zn finger	258..278	CDD:275368	10/19 (53%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	316..336	CDD:275368	4/19 (21%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
Plag1	NP_064353.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		5/24 (21%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		28/75 (37%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	10/19 (53%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		51/200 (26%)
		SFP1	<58..139	CDD:227516	25/80 (31%)
		C2H2 Zn finger	64..86	CDD:275368	8/21 (38%)
		zf-H2C2_2	79..101	CDD:463886	7/21 (33%)
		C2H2 Zn finger	94..114	CDD:275368	4/19 (21%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		C2H2 Zn finger	152..172	CDD:275368	0/19 (0%)
		C2H2 Zn finger	187..207	CDD:275368	5/19 (26%)
		C2H2 Zn finger	215..233	CDD:275368	4/17 (24%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		5/13 (38%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..400
		Massively activates transcription. /evidence=ECO:0000250	384..499