DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10959 and zbtb24

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001018866.2	Gene:	zbtb24 / 553955	ZFINID:	ZDB-GENE-081022-123	Length:	678	Species:	Danio rerio

Alignment Length:	489	Identity:	130/489 - (26%)
Similarity:	198/489 - (40%)	Gaps:	90/489 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 HCLANVDYVRLHAQQQLRPKCGEIFYEPEANRFQLVCLLCDMKHFGFEDFARHIRNVHFDKQGRP 68
            |...:.|.: ||....||             |.:|:|           |....:.:|||......
Zfish    20 HSATHKDTI-LHKFDTLR-------------RSELLC-----------DITLIVEDVHFKAHKAL 59

  Fly    69 LTKTVTGLGRL-AREEQ------EFQGVSAEPLA------------VDSFKKE-------YLPNE 107
            |..:......| ..|||      :..|::|...:            ||....|       :|...
Zfish    60 LAASSEYFSALFTAEEQVSQSLYKLDGMTANTFSSVLEFMYSAVVLVDESSSEQLMEMARFLVIP 124

  Fly   108 DVLSEEED---AEQELGLEQDEGNPLRIMVLGGKQSVDEETIDTMWQPDHDSSSASVNEGCALEA 169
            |::...||   .::.:.:::..|.|.:...|..|::.:.|.     |....|....|||..|..|
Zfish   125 DLIKAHEDLQAVDEHMQVKRKRGRPKKNQDLSQKENPESEL-----QAQSSSEIQEVNEEPASPA 184

  Fly   170 LLGVE---NPQD------------------YQPDE--DGEEHQSVFKKQRQP-KDYNCPHCDRRY 210
            ..|.:   ||::                  ::.|:  :|:|.....::::.| .:..|..|.:.:
Zfish   185 TDGSDGEFNPREERRREGKRKIKQPIRLKGFRMDDLMEGKEPGKRGRRRKYPDTEARCEECGKVF 249

  Fly   211 TTQKYLNTHLKMSHPFPQAFKCVDCKATFDVDRALAQHRRKEHT---EFACQLCDKVFKSSRSLL 272
            .:..:|..| :.:|...:.|:|..|...|.....|..|:|. ||   .:.|.:|.|...:..|||
Zfish   250 KSHLFLKIH-QRTHTGEKPFRCSVCGKEFTQKHTLLVHQRM-HTGEKPYICTVCSKALSTKHSLL 312

  Fly   273 RHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYRSRYREALIVHRRTHT 337
            .|:..|:..:.|.|  |.|||||..|..|.||.|||:.:....|..|.::......|..|.||||
Zfish   313 EHMNLHTENKLFTC--EECGKSFSQQRQLKSHNRVHTGKGLPECAECHHKFMDAAQLKKHLRTHT 375

  Fly   338 GEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSRPKALYHHKHLHLGIKKFKCKI 402
            |||||.|:.|.:.|.:||.|..|..:|..||||.|..||..||.|.|...|:..|.|.|.|.|.|
Zfish   376 GEKPFTCEICGKCFTAKSTLQTHIRIHRGEKPYVCKVCDKTFSDPSARRRHEVSHTGKKTFSCSI 440

  Fly   403 CGNAYAQAAGLSAHMRAHKLQASVNATEGAEAEP 436
            |..::|:...|.||::.|..:......|..:..|
Zfish   441 CKVSFARKDNLKAHIKTHNKENPPAQAESTDKPP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	6/20 (30%)
		COG5048	<258..416	CDD:227381	65/157 (41%)
		C2H2 Zn finger	258..278	CDD:275368	7/19 (37%)
		C2H2 Zn finger	289..308	CDD:275368	11/18 (61%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		zf-H2C2_2	328..353	CDD:290200	14/24 (58%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		zf-H2C2_2	357..381	CDD:290200	11/23 (48%)
		C2H2 Zn finger	372..392	CDD:275368	8/19 (42%)
		C2H2 Zn finger	400..420	CDD:275368	7/19 (37%)
zbtb24	NP_001018866.2	BTB	32..129	CDD:279045	21/120 (18%)
		BTB	43..129	CDD:197585	16/85 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	139..211		15/76 (20%)
		C2H2 Zn finger	242..262	CDD:275368	4/20 (20%)
		zf-H2C2_2	255..279	CDD:290200	7/24 (29%)
		COG5048	<266..456	CDD:227381	76/192 (40%)
		C2H2 Zn finger	270..290	CDD:275368	6/20 (30%)
		zf-H2C2_2	283..307	CDD:290200	8/24 (33%)
		C2H2 Zn finger	298..318	CDD:275368	7/19 (37%)
		zf-H2C2_2	310..335	CDD:290200	13/26 (50%)
		zf-C2H2	324..346	CDD:278523	13/23 (57%)
		C2H2 Zn finger	326..346	CDD:275368	12/21 (57%)
		C2H2 Zn finger	354..374	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..390	CDD:290200	13/22 (59%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..418	CDD:290200	10/22 (45%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		zf-C2H2	436..458	CDD:278523	8/21 (38%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000