Protein Alignment CG10959 and PLAG1

DIOPT Version :10

• Sequence 1: NP_572451.1
• Gene: CG10959 / 31743
• FlyBaseID: FBgn0030010
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_002646.2
• Gene: PLAG1 / 5324
• HGNCID: 9045
• Length: 500
• Species: Homo sapiens
• Alignment Length: 252
• Identity: 66/252 - (26%)
• Similarity: 104/252 - (41%)
• Gaps: 47/252 - (18%)

  Fly   234 DCKATFDVDRALAQHRRKEHTE----FACQLCDKVFKSSRSLLRHVQGHSGARTFKCEHENCGKS 294
            |.....|..:..:..|::..|:    |.||||||.|.|...|..|...|:|.|.:||..::|.|:
Human     8 DLSEVRDTQKVPSGKRKRGETKPRKNFPCQLCDKAFNSVEKLKVHSYSHTGERPYKCIQQDCTKA 72

  Fly   295 FVNQHNLTSHRRVHSEERNYVCELCGYRSRYREALIVHRRTHTGEK-PFQCQTCARRFASKSLLN 358
            ||:::.|..|...||.|:.:.|..|......::.|..|..||...| .|:|:.|.:.:.:|....
Human    73 FVSKYKLQRHMATHSPEKTHKCNYCEKMFHRKDHLKNHLHTHDPNKETFKCEECGKNYNTKLGFK 137

  Fly   359 EHQAMHST------------------------------------EKPYKCDKCDSAFSRPKALYH 387
            .|.|:|:.                                    ||.::|:.||..|...|.:..
Human   138 RHLALHAATSGDLTCKVCLQTFESTGVLLEHLKSHAGKSSGGVKEKKHQCEHCDRRFYTRKDVRR 202

  Fly   388 HKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAHKLQASVNATEGAEAEPIEML--FT 442
            |..:|.|.|.|.|:.|...:.:...|:.||:....|..:.    .:.||::.|  ||
Human   203 HMVVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLK----VKTEPVDFLDPFT 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	3/18 (17%)
		COG5048	<258..416	CDD:227381	53/194 (27%)
		C2H2 Zn finger	258..278	CDD:275368	10/19 (53%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	316..336	CDD:275368	4/19 (21%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
PLAG1	NP_002646.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		4/21 (19%)
		Interaction with KPNA2. /evidence=ECO:0000269|PubMed:11882654	2..84		26/75 (35%)
		Nuclear localization signal	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	10/19 (53%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm	41..242		51/200 (26%)
		SFP1	<58..139	CDD:227516	24/80 (30%)
		C2H2 Zn finger	64..86	CDD:275368	7/21 (33%)
		zf-H2C2_2	79..101	CDD:463886	7/21 (33%)
		C2H2 Zn finger	94..114	CDD:275368	4/19 (21%)
		C2H2 Zn finger	123..143	CDD:275368	5/19 (26%)
		C2H2 Zn finger	152..172	CDD:275368	0/19 (0%)
		C2H2 Zn finger	187..207	CDD:275368	6/19 (32%)
		C2H2 Zn finger	215..233	CDD:275368	4/17 (24%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction	243..500		5/13 (38%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity	243..384		5/13 (38%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..388
		Massively activates transcription	385..500