DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10959 and ZNF589

DIOPT Version :9

Sequence 1:NP_572451.1 Gene:CG10959 / 31743 FlyBaseID:FBgn0030010 Length:443 Species:Drosophila melanogaster
Sequence 2:NP_057173.2 Gene:ZNF589 / 51385 HGNCID:16747 Length:364 Species:Homo sapiens


Alignment Length:308 Identity:77/308 - (25%)
Similarity:116/308 - (37%) Gaps:82/308 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   187 EHQSVFKK-------------QRQPKDYNCPHCDRRYTTQKYLNTHLKMSHPFP------QAFKC 232
            |.::::|:             :.:|:.:.||.|...:.:|::|:.....:||.|      |....
Human    55 EQRNLYKEVMLENLRNLVSLAESKPEVHTCPSCPLAFGSQQFLSQDELHNHPIPGFHAGNQLHPG 119

  Fly   233 VDCKATFDVDRALAQHRRKEHTEFACQLCDKVFKSSRSL-------------------------- 271
            ..|..    |:..:||...::...|.....:|....|.|                          
Human   120 NPCPE----DQPQSQHPSDKNHRGAEAEDQRVEGGVRPLFWSTNERGALVGFSSLFQRPPISSWG 180

  Fly   272 --------LRHVQGHS----------------GARTFKCEHENCGKSFVNQHNLTSHRRVHSEE- 311
                    |...|..|                ||.||    ..|..:|..:.||...:.|.:|: 
Human   181 GNRILEIQLSPAQNASSEEVDRISKRAETPGFGAVTF----GECALAFNQKSNLFRQKAVTAEKS 241

  Fly   312 ----RNYVCELCGYRSRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKC 372
                ::.||..||.....:..||:|:||||||||:.|..|.|.|..:|:|..|.:.||.||||.|
Human   242 SDKRQSQVCRECGRGFSRKSQLIIHQRTHTGEKPYVCGECGRGFIVESVLRNHLSTHSGEKPYVC 306

  Fly   373 DKCDSAFSRPKALYHHKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAH 420
            ..|...||....|..|:..|...|.|.|.:||..:.:.:.|..|.|.|
Human   307 SHCGRGFSCKPYLIRHQRTHTREKSFMCTVCGRGFREKSELIKHQRIH 354

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10959NP_572451.1 C2H2 Zn finger 232..253 CDD:275368 4/20 (20%)
COG5048 <258..416 CDD:227381 57/212 (27%)
C2H2 Zn finger 258..278 CDD:275368 5/53 (9%)
C2H2 Zn finger 289..308 CDD:275368 4/18 (22%)
C2H2 Zn finger 316..336 CDD:275368 7/19 (37%)
zf-H2C2_2 328..353 CDD:290200 15/24 (63%)
C2H2 Zn finger 344..364 CDD:275368 7/19 (37%)
zf-H2C2_2 357..381 CDD:290200 11/23 (48%)
C2H2 Zn finger 372..392 CDD:275368 6/19 (32%)
C2H2 Zn finger 400..420 CDD:275368 6/19 (32%)
ZNF589NP_057173.2 KRAB 35..84 CDD:214630 3/28 (11%)
KRAB 35..74 CDD:279668 2/18 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 103..148 9/48 (19%)
COG5048 223..>311 CDD:227381 35/87 (40%)
zf-C2H2 249..270 CDD:278523 8/20 (40%)
C2H2 Zn finger 250..270 CDD:275368 7/19 (37%)
zf-H2C2_2 263..285 CDD:290200 14/21 (67%)
C2H2 Zn finger 278..298 CDD:275368 7/19 (37%)
zf-H2C2_2 291..315 CDD:290200 11/23 (48%)
COG5048 302..>364 CDD:227381 19/53 (36%)
C2H2 Zn finger 306..326 CDD:275368 6/19 (32%)
zf-H2C2_2 318..341 CDD:290200 8/22 (36%)
zf-C2H2 332..354 CDD:278523 7/21 (33%)
C2H2 Zn finger 334..354 CDD:275368 6/19 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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