DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10959 and Sry-delta

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_524581.1	Gene:	Sry-delta / 43572	FlyBaseID:	FBgn0003512	Length:	433	Species:	Drosophila melanogaster

Alignment Length:	447	Identity:	98/447 - (21%)
Similarity:	150/447 - (33%)	Gaps:	124/447 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRHCLANVDYVRLHAQQQLRP---KCGEIFYEPEANRFQLVCLLCDMKHFGFEDFARHIRNVHF 62
            :|.| |||.    :..|..|:|   .|...|.|.......:|.|:...|.
  Fly    40 VLTH-LANC----IQTQLDLKPGARLCPRCFQELSDYDTIMVNLMTTQKR--------------- 84

  Fly    63 DKQGRPLTKTVTGLGRLAREEQEFQGVSAEPLAVDSFKKEYLPNEDVLSEEEDAEQ-----ELGL 122
                  ||..:.|..:...|..|    |.|.:.|:..:   :|..|| ..:.|||.     ||..
  Fly    85 ------LTTQLKGALKSEFEVPE----SGEDILVEEVE---IPQSDV-ETDADAEADALFVELVK 135

  Fly   123 EQDEGNPLRIMVLGGKQSVDEETIDTMWQPDHDSSSASVNEGCAL---EALLGVENPQDYQPDED 184
            :|:|.:          ..:..|.:|...:.|.|.....:.|...:   |||        |....|
  Fly   136 DQEESD----------TEIKREFVDEEEEEDDDDDDEFICEDVDVGDSEAL--------YGKSSD 182

  Fly   185 GEEHQSVFKKQRQPKDYNCPHCDRRYTTQKYLNTHLKMSHPFPQAFKCVDCKATFDVDRALAQHR 249
            ||:..:   |:|..::  |..|.:.|.:...|..|:...|                       .:
  Fly   183 GEDRPT---KKRVKQE--CTTCGKVYNSWYQLQKHISEEH-----------------------SK 219

  Fly   250 RKEHTEFACQLCDKVFKSSRSLLRHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNY 314
            :..|   .|.:|..:.:....|..|:..|.|....:|.:  |.|||....|...|.|:|.:::.|
  Fly   220 QPNH---ICPICGVIRRDEEYLELHMNLHEGKTEKQCRY--CPKSFSRPVNTLRHMRMHWDKKKY 279

  Fly   315 VCELCGYRSRYREALIVHRRTHTGEK-PFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSA 378
            .||.||.|......|..||..|..|: |..|..|...|.|:...|.|..:|...:|
  Fly   280 QCEKCGLRFSQDNLLYNHRLRHEAEENPIICSICNVSFKSRKTFNHHTLIHKENRP--------- 335

  Fly   379 FSRPKALYHHKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAHKLQASVNATEGAEAE 435
                      :|.        |.:|..::.:...|..||:.|:........|.|.|:
  Fly   336 ----------RHY--------CSVCPKSFTERYTLKMHMKTHEGDVVYGVREEAPAD 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	0/20 (0%)
		COG5048	<258..416	CDD:227381	39/158 (25%)
		C2H2 Zn finger	258..278	CDD:275368	4/19 (21%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	316..336	CDD:275368	8/19 (42%)
		zf-H2C2_2	328..353	CDD:290200	9/25 (36%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		zf-H2C2_2	357..381	CDD:290200	4/23 (17%)
		C2H2 Zn finger	372..392	CDD:275368	1/19 (5%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
Sry-delta	NP_524581.1	COG5048	<205..360	CDD:227381	45/209 (22%)
		C2H2 Zn finger	225..245	CDD:275368	4/19 (21%)
		C2H2 Zn finger	253..273	CDD:275368	8/21 (38%)
		C2H2 Zn finger	281..301	CDD:275368	8/19 (42%)
		C2H2 Zn finger	310..327	CDD:275370	5/16 (31%)
		zf-C2H2	337..359	CDD:278523	6/29 (21%)
		C2H2 Zn finger	339..359	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	59	1.000	Inparanoid score	I2552
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.050