DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10959 and ZIPIC

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_651765.1	Gene:	ZIPIC / 43566	FlyBaseID:	FBgn0039740	Length:	457	Species:	Drosophila melanogaster

Alignment Length:	451	Identity:	109/451 - (24%)
Similarity:	181/451 - (40%)	Gaps:	114/451 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLRHCLANVDYV-----------------RLHAQ----QQLRPKCGEIFYEPEANRFQLVCLLCD 44
            ::..|....:||                 |.|..    ::||.:..|:.:.|..::        |
  Fly    31 LVLQCTRGTNYVLTEESSTICKKCCEKLARYHKSIQIARKLRGEILELIHSPYMSK--------D 87

  Fly    45 MKHFGF--EDFARHIRNVHFD-------------KQGRPLTKTVTGLG----------------- 77
            .|...:  :|..|......||             ::...:..|||.:|
  Fly    88 HKQTSYKEDDLDRETTISKFDGNIEEAQQQDEEEQELESVGTTVTLVGPAGIVEEVAEEEHTFII 152

  Fly    78 RLAREEQEFQGVSAEPLAVDSFKKEYLPNEDVLSEEEDAE--------QELGLEQDEGNPLRIMV 134
            :.:.||.||..|..| |.:|        ||.:::|||..|        :|:..|.:|.:    ::
  Fly   153 KQSEEEDEFHSVDLE-LDID--------NEIIINEEEAHEVEEVAHEIEEVAHEIEEED----LL 204

  Fly   135 LGGKQSVDEETI---DTMWQPDHDSSSASVNEGCALEALLGVENPQDYQPDEDGEEHQSVFKKQR 196
            ...||...||..   |||  .|.|...    :| |:|.::.....|:...:..||...::
  Fly   205 PHDKQEAQEEDFFKEDTM--SDFDEHL----DG-AIEYIISDGEDQEQDNESSGEYTVNI----- 257

  Fly   197 QPKDYNCPHCDRRYTTQKYLNTHLKMSHPFPQAFKCVDCKATFDVDRALAQHRRKEH--TEFACQ 259
                 .||.|..::::::..|.|.|..| || .:.|..|..|.........|.:...  .:|||.
  Fly   258 -----QCPSCPEKFSSRRAYNVHTKREH-FP-GYVCDQCGKTLQSYSGFIGHLQNHEPVKQFACP 315

  Fly   260 LCDKVFKSSRSLLRHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVH-SEERNYVCELCGYRS 323
            :|.:.|.....|..|:..|||...::|  :.|.|.||::..|..|:.:| ||.:...|::||:::
  Fly   316 VCPERFSRKFRLKHHMAWHSGETPYQC--DVCSKRFVHKVALYKHKMIHDSETKRLECQVCGFKT 378

  Fly   324 RYREALIVHRRTHTGEKPFQCQTCARRFAS----KSLLNEHQAMHST-EKPYKCDKCDSAF 379
            |.:..|..|.|:|||:|||.|..|.:||:.    |:.|.||::..:. .:.:.|.||...|
  Fly   379 RTKAHLERHMRSHTGDKPFACPVCNKRFSQMYNMKAHLREHESPGTNRHRRFHCSKCTHTF 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	4/20 (20%)
		COG5048	<258..416	CDD:227381	43/128 (34%)
		C2H2 Zn finger	258..278	CDD:275368	5/19 (26%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	316..336	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..353	CDD:290200	13/24 (54%)
		C2H2 Zn finger	344..364	CDD:275368	8/23 (35%)
		zf-H2C2_2	357..381	CDD:290200	7/24 (29%)
		C2H2 Zn finger	372..392	CDD:275368	4/8 (50%)
		C2H2 Zn finger	400..420	CDD:275368
ZIPIC	NP_651765.1	C2H2 Zn finger	286..306	CDD:275368	4/19 (21%)
		C2H2 Zn finger	314..334	CDD:275368	5/19 (26%)
		zf-H2C2_2	327..351	CDD:290200	9/25 (36%)
		C2H2 Zn finger	342..391	CDD:275368	17/50 (34%)
		zf-H2C2_2	383..408	CDD:290200	13/24 (54%)
		C2H2 Zn finger	399..419	CDD:275368	6/19 (32%)
		C2H2 Zn finger	432..449	CDD:275368	4/8 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	59	1.000	Inparanoid score	I2552
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.960