DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10959 and CG6689

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_650051.1	Gene:	CG6689 / 41345	FlyBaseID:	FBgn0037877	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	627	Identity:	129/627 - (20%)
Similarity:	205/627 - (32%)	Gaps:	243/627 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 HAQQQLR------PKCGEIF--------YEPEANRFQLVCLLCDMKHFGFEDF------------ 53
            :|.||.|      |||.:.|        |..|:.:.:..| :| ::||..||.
  Fly    19 NAAQQQRLGFFRFPKCPDTFKAWLAFCGYTEESLKLKNPC-IC-IEHFKDEDIEGSLKFEMGLAK 81

  Fly    54 ----------------------ARHIRN--------------------VH-----FDKQGRPLTK 71
                                  ||..|:                    :|     |::....|::
  Fly    82 KRTLRPGAVPCVNKSQESGSDRARKERSQRRRNQELVAELLAEEEAKLIHPEATSFEQDSVYLSE 146

  Fly    72 TVT-GLGRLAREE--QEFQ----------------------------------GV---------- 89
            ||| .|..|:.||  :|.|                                  ||
  Fly   147 TVTMELDPLSGEEKLEELQKCRTCYNDFTADFRAKDLFDPANSVLLFHIEVISGVWISHKPDEPR 211

  Fly    90 -------SAEPLAVDSFKKEYLPNEDVLSEEEDAEQELGLEQDEGNPL----------------R 131
                   ||...|:| |::..:..|..||:.:.:..|:.:|.:..||:                .
  Fly   212 LMCPACKSALDQAID-FREMCISTELKLSQAKPSTDEVQIEAENENPISSDHDLISDTENTNVEE 275

  Fly   132 IMVLGGKQSVDEETIDTMWQPDHDSSSA--------------SVNEGC----------------- 165
            |...||....||.|.|     |..|..|              ||..|.
  Fly   276 IEDAGGDHVEDEATSD-----DQTSQEAVDEVAESPAAQDPLSVALGAKIFKELLDQYTGKEKAR 335

  Fly   166 ------------ALEALLGVENPQDYQPDEDGEEHQSVFKKQ--RQPKDYNCPHCDRRYTTQKYL 216
                        |.|...|.:.|:.....:..||...:.:.|  .:|.::.|..|.:.:.....|
  Fly   336 LRKGAPIASKPKAKEKAAGEQKPKRSANPKTKEERNLIRRAQLRAKPPNFVCDQCGQAFRMSHNL 400

  Fly   217 NTHLKMSHPFPQAFKCVDCKATFDVDRALAQHRRKEH---TEFACQLCDKVFKSSRSLLRHVQGH 278
            ..|: :.|...:.::|.:|..||........|.|..|   |.|||..|.:.|           .:
  Fly   401 RIHM-LRHTRTKNYQCTECPKTFYDAYMRNMHIRIRHRGETPFACGFCSETF-----------AY 453

  Fly   279 SGARTFKCEHENCGKSFVNQHNLTSH---RRVH-------SEERNYVCELC--GYRSRYREALIV 331
            .|||.   :||:      ..||....   :|::       .|...|.|:||  .|.|:|  ||..
  Fly   454 PGARQ---KHES------EVHNAAPRLIVKRINPKPMPKPRESVRYQCKLCQKHYASKY--ALGW 507

  Fly   332 HRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSRPKALYHHKHLHLGIK 396
            |.::||....::||.|::.::..:.|..|:..|. ::|.:||.|...|.:...|..|:.:|.|.:
  Fly   508 HIKSHTDANAYKCQRCSKSYSDPNKLKRHEMTHE-KRPLQCDVCLKGFYQRTRLREHELIHTGER 571

  Fly   397 KFKCKICGNAYAQAAGLSAHM-------RAHKL-QASVNATE 430
            .:.|::|...:.....:.:|.       .|.|| ...:.|||
  Fly   572 PYWCEVCNVNFRYKYNMKSHANSKMHQDNARKLGVVQIVATE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	6/20 (30%)
		COG5048	<258..416	CDD:227381	41/169 (24%)
		C2H2 Zn finger	258..278	CDD:275368	3/19 (16%)
		C2H2 Zn finger	289..308	CDD:275368	4/21 (19%)
		C2H2 Zn finger	316..336	CDD:275368	9/21 (43%)
		zf-H2C2_2	328..353	CDD:290200	8/24 (33%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..381	CDD:290200	8/23 (35%)
		C2H2 Zn finger	372..392	CDD:275368	6/19 (32%)
		C2H2 Zn finger	400..420	CDD:275368	3/26 (12%)
CG6689	NP_650051.1	THAP	2..96	CDD:283206	16/78 (21%)
		zf-AD	167..240	CDD:214871	9/73 (12%)
		zf-C2H2	385..407	CDD:278523	4/22 (18%)
		C2H2 Zn finger	387..407	CDD:275368	4/20 (20%)
		zf-H2C2_2	399..422	CDD:290200	5/23 (22%)
		C2H2 Zn finger	415..436	CDD:275368	6/20 (30%)
		C2H2 Zn finger	444..460	CDD:275368	6/29 (21%)
		C2H2 Zn finger	492..512	CDD:275368	9/21 (43%)
		C2H2 Zn finger	520..540	CDD:275368	5/19 (26%)
		C2H2 Zn finger	547..567	CDD:275368	6/19 (32%)
		zf-met	574..597	CDD:289631	3/22 (14%)
		C2H2 Zn finger	575..591	CDD:275368	2/15 (13%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457881
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840