DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10959 and CG8159

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_649823.2	Gene:	CG8159 / 41040	FlyBaseID:	FBgn0037619	Length:	399	Species:	Drosophila melanogaster

Alignment Length:	366	Identity:	84/366 - (22%)
Similarity:	137/366 - (37%)	Gaps:	91/366 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 SFKKEYLPNEDVLSEEEDAEQELGLEQDEGNPLRIMVLGGKQSVDEETIDTMWQPDHDSSSASVN 162
            ||:...|.::.:..|        .|.::|.:..|..|....:|..:...||          |...
  Fly    64 SFRDRCLRSQKIFEE--------SLVRNEEDTFRSSVRRSARSQRQRHEDT----------APKT 110

  Fly   163 EGCALEALLGVENPQDYQPDEDGEEHQSVFKKQRQPKDYNCPHCDRRYTTQKYLNTHLKMSHPFP 227
            ....||.::.:|:..:...::||.:|..           :|...|...
  Fly   111 PASPLEVMIKLESLSNGDEEDDGIDHLD-----------SCNEADMEL----------------- 147

  Fly   228 QAFKCVDCKATFDVDRA---LAQHRRK---------EHTE-----FACQLCDKVFKSSRSLLRHV 275
             |.|.:......|...:   |.:.||:         ..|:     |.|..|........|..||:
  Fly   148 -AIKAMSSSTEDDGTTSPVRLKRTRRRGLKKGGKGENRTKVTLPVFFCDQCGNNITGKSSFDRHL 211

  Fly   276 QGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELC-----GYRSRYREALIVHRRT 335
            :.|||.|.|:|  |.|...|::...|..|:.:|:.:|.:.|..|     .|..|.|     |.||
  Fly   212 RKHSGIRPFQC--ELCPARFLSSGELKGHQVMHTGDRKFQCRYCDRTYVNYSGRLR-----HERT 269

  Fly   336 HTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSRPKALYHH----KHLHLGIK 396
            ||.::||.|..|.:.|.:..:|..|..:|:.|:.::|:.|..:|:||..|..|    .|.| .::
  Fly   270 HTNDRPFICAQCGKSFTNSYILKNHMLIHTGERLFRCELCHRSFARPTHLKTHFRSNTHKH-NLE 333

  Fly   397 KFKCKICGNAYAQAAG--LSAHMRAHKLQASVNATEGAEAE 435
            |        :.|.|.|  ||....|.:::........|||:
  Fly   334 K--------SMADAGGVQLSPSQSADQVKFVTEKEPEAEAD 366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	4/32 (13%)
		COG5048	<258..416	CDD:227381	52/168 (31%)
		C2H2 Zn finger	258..278	CDD:275368	5/19 (26%)
		C2H2 Zn finger	289..308	CDD:275368	5/18 (28%)
		C2H2 Zn finger	316..336	CDD:275368	7/24 (29%)
		zf-H2C2_2	328..353	CDD:290200	10/24 (42%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..381	CDD:290200	7/23 (30%)
		C2H2 Zn finger	372..392	CDD:275368	8/23 (35%)
		C2H2 Zn finger	400..420	CDD:275368	5/21 (24%)
CG8159	NP_649823.2	zf-AD	5..78	CDD:214871	3/13 (23%)
		C2H2 Zn finger	194..214	CDD:275368	5/19 (26%)
		COG5048	<197..322	CDD:227381	42/131 (32%)
		zf-H2C2_2	206..231	CDD:290200	12/26 (46%)
		C2H2 Zn finger	222..242	CDD:275368	6/21 (29%)
		C2H2 Zn finger	250..270	CDD:275368	7/24 (29%)
		zf-H2C2_2	265..287	CDD:290200	11/26 (42%)
		C2H2 Zn finger	278..298	CDD:275368	5/19 (26%)
		zf-H2C2_2	291..315	CDD:290200	7/23 (30%)
		C2H2 Zn finger	306..328	CDD:275368	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010