DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10959 and CG7386

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_648036.1	Gene:	CG7386 / 38719	FlyBaseID:	FBgn0035691	Length:	662	Species:	Drosophila melanogaster

Alignment Length:	369	Identity:	88/369 - (23%)
Similarity:	145/369 - (39%)	Gaps:	61/369 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 LTKTVTGLGRLAREEQEFQGVSAEPLAVDSFKKEYLPNEDVLSEEEDAEQELGLEQDEGNPLRIM 133
            |.|....|...:|::.|....|||...::..|||   :|...|::|.|..:..:..|:....|:|
  Fly   134 LEKVDKELEEHSRDQSEEHFSSAEHNGLEEEKKE---SEGFNSDDEQAMGQRRIANDKRKLFRLM 195

  Fly   134 VLGGKQSVDEETIDTMWQPDHDSSSASVNEGCALEALLGVENPQDYQPDEDGEEHQSVFKKQRQP 198
                                    |.|:.:             |.::.....|||   .|.....
  Fly   196 ------------------------SCSICQ-------------QKFKKQSKFEEH---MKHHNDL 220

  Fly   199 KDYNCPH--CDRRYTTQKYLNTHLKMSHPFPQ-AFKCV--DCKATFDVDRALAQHRRKEHT---- 254
            ..:.|..  |.:.:||...|..|:..:|...: ...|.  .|:..|...|.|..|.:|.|.
  Fly   221 LPFQCQEESCRKGFTTAGALRLHVDYAHSKKEDTVPCTVEGCQLVFSRLRLLTIHLKKVHNQARV 285

  Fly   255 -----EFACQLCDKVFKSSRSLLRHVQGHSGAR-TFKCEHENCGKSFVNQHNLTSHRRVHSEERN 313
                 |.:|:.|..||:...::.:|:..|:|.. .:.|  ..|||.|.....|.:|...|:..:|
  Fly   286 IAPRGEQSCKECGVVFRCPVAMKKHMYTHTGEELPYPC--TICGKGFYINSALKNHLLRHAGIKN 348

  Fly   314 YVCELCGYRSRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEH-QAMHSTEKPYKCDKCDS 377
            |||:.||.|...|:....|...||....|:|:.|.....:|.:|..| :.:|...:.:.|..|..
  Fly   349 YVCQYCGVRKTTRQEWSKHILIHTQRNQFKCRICDYATHTKRVLESHVKIVHEKIRNFACQYCGK 413

  Fly   378 AFSRPKALYHHKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAHK 421
            .|.:..|...|:..|.|.|:.:||:|...:..:..|:.|::.|:
  Fly   414 TFGKAYACKIHEMAHTGEKRCECKVCDKKFLHSESLNNHLKIHE 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	7/22 (32%)
		COG5048	<258..416	CDD:227381	45/159 (28%)
		C2H2 Zn finger	258..278	CDD:275368	5/19 (26%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..353	CDD:290200	6/24 (25%)
		C2H2 Zn finger	344..364	CDD:275368	5/20 (25%)
		zf-H2C2_2	357..381	CDD:290200	6/24 (25%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
CG7386	NP_648036.1	zf-AD	10..81	CDD:214871
		C2H2 Zn finger	197..217	CDD:275368	6/35 (17%)
		C2H2 Zn finger	294..314	CDD:275368	5/19 (26%)
		C2H2 Zn finger	323..343	CDD:275368	7/21 (33%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..400	CDD:275368	5/20 (25%)
		C2H2 Zn finger	408..428	CDD:275368	5/19 (26%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	534..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		zf-H2C2_2	575..600	CDD:290200
		C2H2 Zn finger	591..611	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010