DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10959 and Cf2

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001350854.1	Gene:	Cf2 / 33692	FlyBaseID:	FBgn0000286	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	467	Identity:	99/467 - (21%)
Similarity:	158/467 - (33%)	Gaps:	115/467 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LANVDYVR------------LHAQQQLRPKCGEIFYEPE--ANRFQLV----------------- 39
            :||:|.::            :|......|.|.:.|..|:  |:..||.
  Fly    49 IANMDTLKTAFLPNLSMDPNVHVSPHYCPMCHQQFERPQHVADHMQLCHGITLNAQGAIATLDGG 113

  Fly    40 -------------CLLCDMKHFGFEDFARHIRNVHFDKQ--GRPLTKTVTGLGRLAREEQEFQGV 89
                         |..||.|.....|...|.|..|....  .|.|..::.|:....::..|::..
  Fly   114 HPQAQQHPKLSHPCFNCDEKFGNAVDLDEHHRLAHQTPAFLSRCLMCSIYGIHSATQQPNEYKCT 178

  Fly    90 SAEPLAVDSFKKEYLPNEDVLSEEEDA---EQELGLEQDEGNPL---RIMVLGGKQSVDEETIDT 148
            ....:...:          :|:..:..   :||..:..|:..|.   |.|.|    :.:|:....
  Fly   179 QCGSICTTA----------MLAAGQQGFMEQQEAAVTPDDQLPAMAPRDMRL----TPEEQHHQQ 229

  Fly   149 MWQPDHDSSSASVNEGCALEALLGVENPQDYQPDEDGEEHQSVFKKQRQPKDYNCPHCDR----- 208
            ..|.:|........           :..|..|..|..|:.|...::|.|.:..:....|:
  Fly   230 QLQAEHHHQQQHQQ-----------QQQQQQQQQELLEQQQREMQEQAQQQQVHHHQQDQDLAGD 283

  Fly   209 ---------RYTTQKYLNTHLKMSHPFPQAF---KCVDCKATFDVDRALAQHRRKEHTEFACQLC 261
                     .....|..|....:||  ||..   :.:....:.||..::..:..:.:........
  Fly   284 QVALKVPPLTVKLNKNANGGAIVSH--PQVIIKEEPLSLSDSGDVVNSVPVYAIQANPGVPAPAS 346

  Fly   262 DKVFKSSRSL---LRHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHS-------EERNYVC 316
            ..|...::::   |.|...|      ||  .:|.|:|.....|..||::|:       :||.|.|
  Fly   347 SGVLVGTQTVPADLAHKIRH------KC--PDCPKTFKTPGTLAMHRKIHTGEADATPKERPYTC 403

  Fly   317 ELCGYRSRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSR 381
            ..||........|..|.|.|||||||.|..|.:.|:.|..|.:|...|:.||||.|..||..|::
  Fly   404 SYCGKSFTQSNTLKQHTRIHTGEKPFHCGYCEKSFSVKDYLTKHIRTHTGEKPYTCPYCDKRFTQ 468

  Fly   382 PKAL-YHHKHLH 392
            ..|| .|...||
  Fly   469 RSALTVHTTKLH 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	2/20 (10%)
		COG5048	<258..416	CDD:227381	49/146 (34%)
		C2H2 Zn finger	258..278	CDD:275368	3/22 (14%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..353	CDD:290200	13/24 (54%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		zf-H2C2_2	357..381	CDD:290200	11/23 (48%)
		C2H2 Zn finger	372..392	CDD:275368	7/20 (35%)
		C2H2 Zn finger	400..420	CDD:275368
Cf2	NP_001350854.1	COG5048	<366..>473	CDD:227381	42/114 (37%)
		C2H2 Zn finger	368..388	CDD:275368	7/21 (33%)
		C2H2 Zn finger	403..423	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..451	CDD:275368	6/19 (32%)
		zf-H2C2_2	443..468	CDD:316026	11/24 (46%)
		C2H2 Zn finger	459..480	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	54	1.000	Inparanoid score	I1809
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.060