DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10959 and Zbtb38

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_001012489.2	Gene:	Zbtb38 / 315936	RGDID:	1310136	Length:	1203	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	82/340 - (24%)
Similarity:	131/340 - (38%)	Gaps:	87/340 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 KKEYLPNEDVLSEEEDAE----QELGLEQ----------DEGNPLRIMVLGGKQSVDEETIDTMW 150
            |.:|...|:.|..|.|.|    ..|||.|          ||.:             |:::.|..|
  Rat   857 KPKYQMQEETLPRESDPETRGDSPLGLCQADCVEMSEAFDEVS-------------DQDSTDKPW 908

  Fly   151 QPDHDSSSASVNEGCALEALLGVENPQDYQPDEDGEEHQSVFK-KQRQPKDYNCPHCDRRYTTQK 214
            :|.:                       :|:|.:..::.:.:.| |.|:.:....|...|||..:.
  Rat   909 RPYY-----------------------NYKPKKKSKQLRKIRKVKWRKERGSRSPVGRRRYPAEL 950

  Fly   215 YLNTHLKMSHPFPQAFKCVDCKATFDVDRALAQHRRKEHTEFACQLCD----------------- 262
            ......:..:| .:..:|.:.|  ...|:|..:...||..:..|:|||
  Rat   951 DRAEMGRRRYP-AELDRCAEVK--LPPDKASEEEENKEMPKLQCELCDGDKAAGAGAEGKPHQHL 1012

  Fly   263 -----------KVFKSSRSLLRHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVC 316
                       |.|:||.:|..|::.|:|.:.::|  :.||:.|..|.||..|.|:|...:.::|
  Rat  1013 TLKPYICELCAKQFQSSSTLKMHMRCHTGEKPYQC--KTCGRRFSVQGNLQKHERIHLGVKEFIC 1075

  Fly   317 ELCGYRSRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTE---KPYKCDKCDSA 378
            :.|.......|.|.:|.|.|||||.:.||.|.:.|...|....|:..|..|   |.:.|.:|...
  Rat  1076 QYCNKAFTLNETLKIHERIHTGEKRYHCQFCFQGFLYLSTKRNHERRHVREHDGKGFACFQCPKI 1140

  Fly   379 FSRPKALYHHKHLHL 393
            .....||..|:..||
  Rat  1141 CKTAAALRMHQKKHL 1155

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	5/20 (25%)
		COG5048	<258..416	CDD:227381	49/167 (29%)
		C2H2 Zn finger	258..278	CDD:275368	10/47 (21%)
		C2H2 Zn finger	289..308	CDD:275368	8/18 (44%)
		C2H2 Zn finger	316..336	CDD:275368	6/19 (32%)
		zf-H2C2_2	328..353	CDD:290200	12/24 (50%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		zf-H2C2_2	357..381	CDD:290200	6/26 (23%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		C2H2 Zn finger	400..420	CDD:275368
Zbtb38	NP_001012489.2	BTB_POZ_ZBTB38_CIBZ	15..128	CDD:349532
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..334
		Interaction with CBFA2T3. /evidence=ECO:0000250\|UniProtKB:Q8NAP3	299..522
		zf-C2H2_8	308..401	CDD:406359
		C2H2 Zn finger	343..363	CDD:275368
		C2H2 Zn finger	372..391	CDD:275368
		C2H2 Zn finger	461..481	CDD:275368
		C2H2 Zn finger	489..509	CDD:275368
		C2H2 Zn finger	517..535	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..644
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..776
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	857..882		7/24 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	895..914		6/54 (11%)
		C2H2 Zn finger	1019..1039	CDD:275368	6/19 (32%)
		zf-H2C2_2	1032..1055	CDD:404364	7/24 (29%)
		zf-C2H2	1045..1067	CDD:395048	9/23 (39%)
		C2H2 Zn finger	1047..1067	CDD:275368	9/21 (43%)
		C2H2 Zn finger	1075..1095	CDD:275368	6/19 (32%)
		zf-H2C2_2	1088..1112	CDD:404364	12/23 (52%)
		C2H2 Zn finger	1103..1123	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1134..1154	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1172..1203
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000