DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10959 and HIC2

DIOPT Version :9

Sequence 1:NP_572451.1 Gene:CG10959 / 31743 FlyBaseID:FBgn0030010 Length:443 Species:Drosophila melanogaster
Sequence 2:NP_055909.2 Gene:HIC2 / 23119 HGNCID:18595 Length:615 Species:Homo sapiens


Alignment Length:390 Identity:93/390 - (23%)
Similarity:131/390 - (33%) Gaps:130/390 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    75 GLGRLAREEQEFQGVSAEPLAVDSFKKE----------YLPNEDV--LSEEEDAE---------- 117
            |||..:.......|...:.|.:|..||.          :|..:|.  ||:.:...          
Human   226 GLGGCSSSTNGSSGGCEQELGLDLSKKSPPLPPATPGPHLTPDDAAQLSDSQHGSPPAASAPPVA 290

  Fly   118 -----QELG--------LEQDEGNPLRIMVLGG---KQSVDEETIDTMW---QP----DHDSSSA 159
                 .|||        ||..|.|.|.::...|   ::|:...|....|   :|    ..:...|
Human   291 NSASYSELGGTPDEPMDLEGAEDNHLSLLEAPGGQPRKSLRHSTRKKEWGKKEPVAGSPFERREA 355

  Fly   160 SVNEGCALEALLGV------------------------------ENPQDYQPD------EDGEEH 188
            .....|..|...||                              ||.:|...|      |.|..|
Human   356 GPKGPCPGEEGEGVGDRVPNGILASGAGPSGPYGEPPYPCKEEEENGKDASEDSAQSGSEGGSGH 420

  Fly   189 QSVFKKQRQ---------PKDYNCPHCDRRYTTQKYLNTHLK----------------------- 221
            .|.....||         ...|.|..|.:.:.:.:.||.|::                       
Human   421 ASAHYMYRQEGYETVSYGDNLYVCIPCAKGFPSSEQLNAHVETHTEEELFIKEEGAYETGSGGAE 485

  Fly   222 -----MSHPF------PQAFKCVDCKATFDVDRALAQHRRKEH---TEFACQLCDKVFKSSRSLL 272
                 :|.|.      |:.|||..|:.|:.....|.|| .|.|   ..|.|.:|.|:|....::.
Human   486 EEAEDLSAPSAAYTAEPRPFKCSVCEKTYKDPATLRQH-EKTHWLTRPFPCNICGKMFTQRGTMT 549

  Fly   273 RHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYRSRYREALIVHRRTHT 337
            ||::.|.|.:.|.|  :.||..|..|:.||.|.||||.|:.|.|:|||.:...:..||.|.|.||
Human   550 RHMRSHLGLKPFAC--DECGMRFTRQYRLTEHMRVHSGEKPYECQLCGGKFTQQRNLISHLRMHT 612

  Fly   338  337
            Human   613  612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10959NP_572451.1 C2H2 Zn finger 232..253 CDD:275368 7/20 (35%)
COG5048 <258..416 CDD:227381 33/80 (41%)
C2H2 Zn finger 258..278 CDD:275368 6/19 (32%)
C2H2 Zn finger 289..308 CDD:275368 8/18 (44%)
C2H2 Zn finger 316..336 CDD:275368 8/19 (42%)
zf-H2C2_2 328..353 CDD:290200 6/10 (60%)
C2H2 Zn finger 344..364 CDD:275368
zf-H2C2_2 357..381 CDD:290200
C2H2 Zn finger 372..392 CDD:275368
C2H2 Zn finger 400..420 CDD:275368
HIC2NP_055909.2 BTB 40..140 CDD:279045
BTB 47..141 CDD:197585
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..167
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..208
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..421 33/191 (17%)
Binding to CtBP 246..250 1/3 (33%)
TMEM119 <300..395 CDD:292352 15/94 (16%)
C2H2 Zn finger 444..464 CDD:275368 5/19 (26%)
zf-C2H2 505..527 CDD:278523 9/22 (41%)
C2H2 Zn finger 507..527 CDD:275368 7/20 (35%)
zf-C2H2 533..555 CDD:278523 7/21 (33%)
C2H2 Zn finger 535..555 CDD:275368 6/19 (32%)
zf-H2C2_2 548..572 CDD:290200 9/25 (36%)
COG5048 559..>613 CDD:227381 25/56 (45%)
C2H2 Zn finger 563..583 CDD:275368 9/21 (43%)
zf-H2C2_2 576..600 CDD:290200 13/23 (57%)
C2H2 Zn finger 591..611 CDD:275368 8/19 (42%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

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