Protein Alignment CG10959 and EGR1

DIOPT Version :10

• Sequence 1: NP_572451.1
• Gene: CG10959 / 31743
• FlyBaseID: FBgn0030010
• Length: 443
• Species: Drosophila melanogaster
• Sequence 2: NP_001955.1
• Gene: EGR1 / 1958
• HGNCID: 3238
• Length: 543
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 88/373 - (23%)
• Similarity: 127/373 - (34%)
• Gaps: 97/373 - (26%)

  Fly    83 EQEFQGVSAEPLAVDSFKKEYLPNEDVLSEEEDAEQ-----------ELGLE--QDEGNPL---- 130
            ||.::.::||     ||....|.||.||.|.....|           ...||  .:.||.|
Human    94 EQPYEHLTAE-----SFPDISLNNEKVLVETSYPSQTTRLPPITYTGRFSLEPAPNSGNTLWPEP 153

  Fly   131 RIMVLGGKQSVDEETIDTMWQPDHDSSSASVNE----GCAL------------------------ 167
            ...::.|..|:......:...|...:||||.::    .||:
Human   154 LFSLVSGLVSMTNPPASSSSAPSPAASSASASQSPPLSCAVPSNDSSPIYSAAPTFPTPNTDIFP 218

  Fly   168 ----EALLGVEN------PQDYQPDEDGEEHQSV----FKKQRQPKDYNCPHCDRR------YTT 212
                :|..|...      |..|...:.|.:...:    |.:|:.......|  |::      ..|
Human   219 EPQSQAFPGSAGTALQYPPPAYPAAKGGFQVPMIPDYLFPQQQGDLGLGTP--DQKPFQGLESRT 281

  Fly   213 QKYLNTHLKMSHPFPQAFKCVDCKATFDVDRALAQHRRKEHTEFACQLCDKVFKSSRSLLRHVQG 277
            |:...|.|.....|.......|.||.              :|.:..||    .|.||  :|....
Human   282 QQPSLTPLSTIKAFATQSGSQDLKAL--------------NTSYQSQL----IKPSR--MRKYPN 326

  Fly   278 HSG-----ARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGYRSRYREALIVHRRTHT 337
            ...     .|.:.|..|:|.:.|.....||.|.|:|:.::.:.|.:|.......:.|..|.||||
Human   327 RPSKTPPHERPYACPVESCDRRFSRSDELTRHIRIHTGQKPFQCRICMRNFSRSDHLTTHIRTHT 391

  Fly   338 GEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSRPKAL 385
            |||||.|..|.|:||.......|..:|..:|..|.||...|.|...:|
Human   392 GEKPFACDICGRKFARSDERKRHTKIHLRQKDKKADKSVVASSATSSL 439

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	3/20 (15%)
		COG5048	<258..416	CDD:227381	43/133 (32%)
		C2H2 Zn finger	258..278	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	316..336	CDD:275368	5/19 (26%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		C2H2 Zn finger	372..392	CDD:275368	5/14 (36%)
		C2H2 Zn finger	400..420	CDD:275368
EGR1	NP_001955.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..105		4/15 (27%)
		DUF3446	135..237	CDD:463400	16/101 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	165..213		7/47 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..284		4/21 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	318..339		4/22 (18%)
		zf-C2H2	338..362	CDD:395048	8/23 (35%)
		C2H2 Zn finger	340..362	CDD:275368	8/21 (38%)
		zf-H2C2_2	354..379	CDD:463886	7/24 (29%)
		C2H2 Zn finger	370..390	CDD:275368	5/19 (26%)
		zf-H2C2_2	382..407	CDD:463886	15/24 (63%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..487		9/31 (29%)
		DUF3432	447..530	CDD:403204