DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10959 and ZNF441

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_689568.2	Gene:	ZNF441 / 126068	HGNCID:	20875	Length:	693	Species:	Homo sapiens

Alignment Length:	424	Identity:	113/424 - (26%)
Similarity:	168/424 - (39%)	Gaps:	70/424 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 YVRLHAQQQLR--PKCGEIFYEPEANRFQLVCLLCDMKHFGFEDFARHIRNVHFDKQGRPLTKTV 73
            |.|.|..:|..  .:||:.||                 |.|  .|.||: .||  ....|....:
Human   270 YERTHTGEQSYECKQCGKAFY-----------------HLG--SFQRHM-IVH--TGDGPHKCKI 312

  Fly    74 TGLGRLAREEQEFQGVSAEPLAVDSFKKEYL---PNE-----DVLSEEEDAEQELGLEQDEGNPL 130
            .|.|.|:            |.:|...|:.:.   |.|     ...|:.....:.:.....:| |.
Human   313 CGKGFLS------------PSSVRRHKRTHTGEKPYECKYCGKAFSDCTGFRRHMITHTGDG-PH 364

  Fly   131 RIMVLGGKQSVDEETIDTMWQPDHDSSSASVNE-GCALEALLGVENPQDYQPDEDGEEHQSVFKK 194
            :..|.|  ::.|..::....:..|........| |.|........|   ::....||
Human   365 KCKVCG--KAFDSPSLCRRHETTHTGEKPYKCECGKAFSDFYYFRN---HETTHTGE-------- 416

  Fly   195 QRQPKDYNCPHCDRRYTTQKYLNTHLKMSHPFPQAFKCVDCKATFDVDRALAQHRRKEHT---EF 256
                |.|.|..|.:.:....||..|.:: |...:.:||..|...|.....:..| .|.||   .:
Human   417 ----KPYKCKQCGKAFICCTYLQIHERI-HTGERPYKCKQCGKAFRSSNYIRVH-EKTHTGEKPY 475

  Fly   257 ACQLCDKVFKSSRSLLRHVQGHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELCGY 321
            .|:.|.|.....:|..||:..|:|....||  :.|||||.:..:...|.|:|:.||.|.|:|||.
Human   476 ECKQCGKALSHLKSFQRHMIMHTGDGPHKC--KICGKSFDSPSSFRRHERIHTGERPYKCKLCGK 538

  Fly   322 RSRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYKCDKCDSAFSRPKALY 386
            ..|....:.:|.||||||||:.||.|.:..:..|....|...|:...|:||..|...|..|.::.
Human   539 GFRSSSYIQLHERTHTGEKPYGCQQCGKALSDLSSFRRHMITHTGNGPHKCKICGKGFDYPSSVQ 603

  Fly   387 HHKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAH 420
            .|:..|.|.|.::||.||.|::.::.|..|.|.|
Human   604 RHERTHTGEKPYECKECGKAFSHSSYLRIHERVH 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	5/20 (25%)
		COG5048	<258..416	CDD:227381	57/157 (36%)
		C2H2 Zn finger	258..278	CDD:275368	6/19 (32%)
		C2H2 Zn finger	289..308	CDD:275368	7/18 (39%)
		C2H2 Zn finger	316..336	CDD:275368	7/19 (37%)
		zf-H2C2_2	328..353	CDD:290200	12/24 (50%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..381	CDD:290200	7/23 (30%)
		C2H2 Zn finger	372..392	CDD:275368	5/19 (26%)
		C2H2 Zn finger	400..420	CDD:275368	8/19 (42%)
ZNF441	NP_689568.2	KRAB	4..>44	CDD:214630
		KRAB	4..40	CDD:279668
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	171..190	CDD:275368
		C2H2 Zn finger	198..218	CDD:275368
		COG5048	222..634	CDD:227381	110/419 (26%)
		C2H2 Zn finger	227..246	CDD:275368
		zf-H2C2_2	241..263	CDD:290200
		C2H2 Zn finger	254..274	CDD:275368	2/3 (67%)
		C2H2 Zn finger	282..302	CDD:275368	9/39 (23%)
		C2H2 Zn finger	310..330	CDD:275368	6/31 (19%)
		zf-H2C2_2	322..346	CDD:290200	4/23 (17%)
		C2H2 Zn finger	338..358	CDD:275368	1/19 (5%)
		zf-H2C2_2	351..375	CDD:290200	4/26 (15%)
		C2H2 Zn finger	366..386	CDD:275368	3/21 (14%)
		C2H2 Zn finger	395..413	CDD:275368	4/20 (20%)
		zf-H2C2_2	405..428	CDD:290200	7/37 (19%)
		C2H2 Zn finger	421..441	CDD:275368	5/20 (25%)
		zf-H2C2_2	433..458	CDD:290200	8/25 (32%)
		C2H2 Zn finger	449..469	CDD:275368	5/20 (25%)
		C2H2 Zn finger	477..497	CDD:275368	6/19 (32%)
		zf-H2C2_2	489..514	CDD:290200	12/26 (46%)
		C2H2 Zn finger	505..525	CDD:275368	8/21 (38%)
		zf-H2C2_2	517..542	CDD:290200	10/24 (42%)
		C2H2 Zn finger	533..553	CDD:275368	7/19 (37%)
		C2H2 Zn finger	561..581	CDD:275368	5/19 (26%)
		C2H2 Zn finger	589..609	CDD:275368	5/19 (26%)
		zf-H2C2_2	601..626	CDD:290200	9/24 (38%)
		C2H2 Zn finger	617..637	CDD:275368	8/19 (42%)
		zf-H2C2_2	629..654	CDD:290200	4/9 (44%)
		C2H2 Zn finger	645..665	CDD:275368
		C2H2 Zn finger	673..693	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000