DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10959 and Bcl6

DIOPT Version :9

Sequence 1:NP_572451.1 Gene:CG10959 / 31743 FlyBaseID:FBgn0030010 Length:443 Species:Drosophila melanogaster
Sequence 2:NP_001334955.1 Gene:Bcl6 / 12053 MGIID:107187 Length:707 Species:Mus musculus


Alignment Length:522 Identity:130/522 - (24%)
Similarity:195/522 - (37%) Gaps:135/522 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    14 LHAQQQLR--PKCGEIFYEPEANRF-QLVCLLCDMKHFGFEDFAR----------HIRNVHFDKQ 65
            |.:.::||  |:.      |.||.| :...|.||.......:::|          | .|::..|:
Mouse   207 LFSDEELRDAPRM------PVANPFPKERALPCDSARQVPNEYSRPAMEVSPSLCH-SNIYSPKE 264

  Fly    66 GRPLTKTVTGLGRLAREEQEFQGVSAEPLAVDSFKK-EYLPNEDVLSEEE--DAEQELGLEQDEG 127
            ..|         ..||.:..:........||.|.:. .|.|.:....|||  .:|.|:.|..:..
Mouse   265 AVP---------EEARSDIHYSVPEGPKPAVPSARNAPYFPCDKASKEEERPSSEDEIALHFEPP 320

  Fly   128 N-PLRIMVLGGKQSVDEETIDTMWQPDHDSSSASVNEGCALEAL--------------------- 170
            | ||....|...||..:...    ||:..:.|.|....|.|:|.                     
Mouse   321 NAPLNRKGLVSPQSPQKSDC----QPNSPTESCSSKNACILQASGSPPAKSPTDPKACNWKKYKF 381

  Fly   171 -------------------LGVENPQDY------QP--DEDGEEHQSVFKKQRQPKDYNCPHCDR 208
                               ||..:|:.|      ||  :....:.||..|.....:|...|...|
Mouse   382 IVLNSLNQNAKPEGSEQAELGRLSPRAYPAPPACQPPMEPANLDLQSPTKLSASGEDSTIPQASR 446

  Fly   209 -------------RYTTQKYLNTHLKMSHPFPQAFKCVDCKA---------------TFDVDRAL 245
                         |.:::.:...::   || |   ||..|.:               ||..:...
Mouse   447 LNNLVNRSLAGSPRSSSESHSPLYM---HP-P---KCTSCGSQSPQHTEMCLHTAGPTFPEEMGE 504

  Fly   246 AQHRRK----EHTEFACQLCDKVFKSSRSLLRH-VQGHSGARTFKCEHENCGKSFVNQHNLTSHR 305
            .|....    |:..|.|..||..|....||.|| :|.||. :.:||  :.|..||..:.||.||:
Mouse   505 TQSEYSDSSCENGTFFCNECDCRFSEEASLKRHTLQTHSD-KPYKC--DRCQASFRYKGNLASHK 566

  Fly   306 RVHSEERNYVCELCGYRSRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPY 370
            .||:.|:.|.|.:||.:......|..|.|.|:||||::|:||..||...:.|..|..:|:.||||
Mouse   567 TVHTGEKPYRCNICGAQFNRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPY 631

  Fly   371 KCDKCDSAFSRPKALYHHKHLHLGIKKFKCKICGNAYAQAAGLSAHMRAH-------KLQASVNA 428
            .|:.|.:.|...:.|..|..:|.|.|.:.|:.|...:...:.|..|:|..       |:|..|:|
Mouse   632 PCEICGTRFRHLQTLKSHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSA 696

  Fly   429 TE 430
            .:
Mouse   697 AD 698

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10959NP_572451.1 C2H2 Zn finger 232..253 CDD:275368 5/39 (13%)
COG5048 <258..416 CDD:227381 58/158 (37%)
C2H2 Zn finger 258..278 CDD:275368 9/20 (45%)
C2H2 Zn finger 289..308 CDD:275368 7/18 (39%)
C2H2 Zn finger 316..336 CDD:275368 6/19 (32%)
zf-H2C2_2 328..353 CDD:290200 13/24 (54%)
C2H2 Zn finger 344..364 CDD:275368 7/19 (37%)
zf-H2C2_2 357..381 CDD:290200 10/23 (43%)
C2H2 Zn finger 372..392 CDD:275368 5/19 (26%)
C2H2 Zn finger 400..420 CDD:275368 5/19 (26%)
Bcl6NP_001334955.1 BTB_POZ_ZBTB27_BCL6 8..125 CDD:349640
PHA03247 <179..429 CDD:223021 49/241 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 275..350 20/78 (26%)
Required for interaction with NuRD complex and for transcriptional repressor activity 377..380 0/2 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 405..469 11/63 (17%)
C2H2 Zn finger 521..542 CDD:275368 9/20 (45%)
C2H2 Zn finger 549..569 CDD:275368 8/21 (38%)
zf-H2C2_2 561..586 CDD:372612 11/24 (46%)
C2H2 Zn finger 577..597 CDD:275368 6/19 (32%)
zf-H2C2_2 589..614 CDD:372612 13/24 (54%)
C2H2 Zn finger 605..625 CDD:275368 7/19 (37%)
zf-H2C2_2 617..642 CDD:372612 10/24 (42%)
C2H2 Zn finger 633..653 CDD:275368 5/19 (26%)
zf-H2C2_2 646..670 CDD:372612 7/23 (30%)
C2H2 Zn finger 661..679 CDD:275368 4/17 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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