DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10959 and ZNF653

DIOPT Version :9

Sequence 1:	NP_572451.1	Gene:	CG10959 / 31743	FlyBaseID:	FBgn0030010	Length:	443	Species:	Drosophila melanogaster
Sequence 2:	NP_620138.2	Gene:	ZNF653 / 115950	HGNCID:	25196	Length:	615	Species:	Homo sapiens

Alignment Length:	396	Identity:	97/396 - (24%)
Similarity:	149/396 - (37%)	Gaps:	88/396 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 HFGFEDFARHIRNVHFDKQGRPLTKTVTGLGRLAREEQEFQGVSAEPLAVDSFKKEYLPNEDVLS 111
            |..|:  ..|:.::  .:||.||.....|.|..|.|......|..:..|..|...|.:|.|
Human   243 HIPFD--VHHVESL--AEQGTPLCSNPAGNGPEALETVVCVPVPVQVGAGPSALFENVPQE---- 299

  Fly   112 EEEDAEQELGLEQDEGNPLRIMVLGGKQSVDEETIDTMWQPDHDSSSASVNEGCALEAL------ 170
                   .|| |.....|:..||.|.:       :..:..|.:|:.:|   ||..|...
Human   300 -------ALG-EVVASCPMPGMVPGSQ-------VIIIAGPGYDALTA---EGIHLNMAAGSGVP 346

  Fly   171 ---LGVE---------------NPQDYQPD----------EDGEEHQSVFKKQRQPKDYNCPHCD 207
               ||.|               .|:..||.          |..:|.:.:...:::.|:.  |...
Human   347 GSGLGEEVPCAMMEGVAAYTQTEPEGSQPSTMDATAVAGIETKKEKEDLCLLKKEEKEE--PVAP 409

  Fly   208 RRYTTQKYLNTHLKMSHPFPQA----FKCVDCKA-TFDVDRALAQHRRKEHTE----------FA 257
            ...||..      :.:.|..:|    ....|..| .:::.:...:.||.:.:.          |.
Human   410 ELATTVP------ESAEPEAEADGEELDGSDMSAIIYEIPKEPEKRRRSKRSRVMDADGLLEMFH 468

  Fly   258 C--QLCDKVFKSSRSLLRHVQ-GHSGARTFKCEHENCGKSFVNQHNLTSHRRVHSEERNYVCELC 319
            |  :.|.:|:.:..|...||. .|...:|..|.|..|||.|...::|..|..:||..|.:.||.|
Human   469 CPYEGCSQVYVALSSFQNHVNLVHRKGKTKVCPHPGCGKKFYLSNHLRRHMIIHSGVREFTCETC 533

  Fly   320 GYRSRYREALIVHRRTHTGEKPFQCQTCARRFASKSLLNEHQAMHSTEKPYK--CDKCDSAFSRP 382
            |...:.:..|.|||||||||.|.||:.|..:...::.||.|...|:.|..|.  ||:|...|.:.
Human   534 GKSFKRKNHLEVHRRTHTGETPLQCEICGYQCRQRASLNWHMKKHTAEVQYNFTCDRCGKRFEKL 598

  Fly   383 KALYHH 388
            .::..|
Human   599 DSVKFH 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10959	NP_572451.1	C2H2 Zn finger	232..253	CDD:275368	4/21 (19%)
		COG5048	<258..416	CDD:227381	48/136 (35%)
		C2H2 Zn finger	258..278	CDD:275368	6/22 (27%)
		C2H2 Zn finger	289..308	CDD:275368	6/18 (33%)
		C2H2 Zn finger	316..336	CDD:275368	9/19 (47%)
		zf-H2C2_2	328..353	CDD:290200	14/24 (58%)
		C2H2 Zn finger	344..364	CDD:275368	5/19 (26%)
		zf-H2C2_2	357..381	CDD:290200	10/25 (40%)
		C2H2 Zn finger	372..392	CDD:275368	5/17 (29%)
		C2H2 Zn finger	400..420	CDD:275368
ZNF653	NP_620138.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..117
		Nuclear localization signal. /evidence=ECO:0000255	107..118
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..236
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..432		6/38 (16%)
		Nuclear localization signal. /evidence=ECO:0000255	445..451		0/5 (0%)
		COG5048	<486..614	CDD:227381	44/119 (37%)
		C2H2 Zn finger	503..522	CDD:275368	6/18 (33%)
		zf-H2C2_2	514..539	CDD:316026	9/24 (38%)
		C2H2 Zn finger	530..550	CDD:275368	9/19 (47%)
		C2H2 Zn finger	558..578	CDD:275368	5/19 (26%)
		C2H2 Zn finger	588..609	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5104
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950