DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and ZNF665

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001340387.1	Gene:	ZNF665 / 79788	HGNCID:	25885	Length:	706	Species:	Homo sapiens

Alignment Length:	415	Identity:	107/415 - (25%)
Similarity:	152/415 - (36%)	Gaps:	123/415 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 HQSLTSESLRQVRALKVDYKEEDSEQEECG----MELDLDSEGR-HSAKIPHSCPHCTKVYQSRK 194
            |..||:..:       :...|:..:.:|||    ....|.|..| |:.:.|:.|..|.|.:..|.
Human   302 HSKLTTHQV-------IHTGEKPYKCKECGKCFTQNSHLASHRRIHTGEKPYKCNECGKAFSVRS 359

  Fly   195 VLERHIMRQHKDTLSPDVDSEDADYEPPKDAPVKSAAQEYKCEHCGKIY-HGKYSLRQHLKRDHD 258
            .|..|                         ..:.:..:.|||..|||:: |..| |.:| :|.|
Human   360 SLTTH-------------------------QTIHTGEKPYKCNECGKVFRHNSY-LAKH-RRIH- 396

  Fly   259 NGE------EGGSAI------------------FTCLECEAQLPRLRLLDEHMVQAHGGA---AC 296
            .||      |.|.|.                  |.|.||.....:...|..|. :.|.|.   .|
Human   397 TGEKPYKCNECGKAFSMHSNLTKHQIIHTGEKPFKCNECVKVFTQYSHLANHR-RIHTGEKPYRC 460

  Fly   297 VVCGRRYKTRHELKRHQLKHTSERNVPCP------------------HPG--------CGKRFFT 335
            ..||:.:..|..|..||..||.|:...|.                  |.|        |||.|..
Human   461 DECGKAFSVRSSLTTHQAIHTGEKPYKCNDCGKVFTQNSHLASHRGIHSGEKPYKCDECGKAFSQ 525

  Fly   336 IRHMRNHGKVHTEQKNFVCESCG---------------------YSC-------RNKETLRVHIR 372
            ...:..|.:|||.:|.:.|..||                     |.|       |:...|.:|.|
Human   526 TSQLARHWRVHTGEKPYKCNECGKAFSVHSSLTIHQTIHTGQKPYKCNDCGKVFRHNSYLAIHQR 590

  Fly   373 SHTGERPFGCQVCDKRFPSHSGLREHMAMHSTERPHVCSVCGATFSRQKGLYHHKFLHADTKQFV 437
            .||||:|:.|..|.|.|..||.|..|..:|:.|:|:.|:.||..|::...|.:|:.:|...|.:.
Human   591 IHTGEKPYKCNECGKAFSVHSNLATHQVIHTGEKPYKCNECGKVFTQNSHLANHRRIHTGEKPYR 655

  Fly   438 CKLCGNAYAQAAGLAGHMRKHRNDE 462
            |..||.|::..:.|..||..|..|:
Human   656 CNECGKAFSVRSTLTTHMAVHTGDK 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	7/19 (37%)
		zf-C2H2_8	323..411	CDD:292531	37/141 (26%)
		C2H2 Zn finger	327..346	CDD:275368	6/26 (23%)
		C2H2 Zn finger	354..374	CDD:275368	9/47 (19%)
		zf-H2C2_2	367..389	CDD:290200	11/21 (52%)
		C2H2 Zn finger	382..402	CDD:275368	8/19 (42%)
		zf-H2C2_2	395..419	CDD:290200	9/23 (39%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
ZNF665	NP_001340387.1	KRAB	37..76	CDD:307490
		COG5048	192..580	CDD:227381	70/313 (22%)
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	264..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368	3/16 (19%)
		C2H2 Zn finger	320..340	CDD:275368	6/19 (32%)
		C2H2 Zn finger	348..368	CDD:275368	6/44 (14%)
		C2H2 Zn finger	376..396	CDD:275368	9/21 (43%)
		C2H2 Zn finger	404..424	CDD:275368	3/19 (16%)
		C2H2 Zn finger	432..452	CDD:275368	5/20 (25%)
		C2H2 Zn finger	460..480	CDD:275368	7/19 (37%)
		C2H2 Zn finger	488..508	CDD:275368	1/19 (5%)
		C2H2 Zn finger	516..536	CDD:275368	5/19 (26%)
		C2H2 Zn finger	544..564	CDD:275368	3/19 (16%)
		C2H2 Zn finger	572..592	CDD:275368	5/19 (26%)
		zf-H2C2_2	584..608	CDD:316026	11/23 (48%)
		C2H2 Zn finger	600..620	CDD:275368	8/19 (42%)
		zf-H2C2_2	612..637	CDD:316026	9/24 (38%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..664	CDD:316026	8/23 (35%)
		C2H2 Zn finger	656..676	CDD:275368	7/19 (37%)
		zf-H2C2_2	669..693	CDD:316026	5/12 (42%)
		C2H2 Zn finger	684..704	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930