DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and ZNF184

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001305820.1	Gene:	ZNF184 / 7738	HGNCID:	12975	Length:	751	Species:	Homo sapiens

Alignment Length:	462	Identity:	120/462 - (25%)
Similarity:	191/462 - (41%)	Gaps:	83/462 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HVQNIHFENGLLKTEATDAGANLKQERDREREPNSPVPIVAQVNPFAWYEIGGDHNEDSDDERV- 112
            |.::..:.:.||  |:.:...:|::::..::.....:.:..:..| :| |.|..:||......|
Human   130 HKRDDSWSSNLL--ESWEYEGSLERQQANQQTLPKEIKVTEKTIP-SW-EKGPVNNEFGKSVNVS 190

  Fly   113 --VLEKQDEDEDERPGRSIIKWQDHQSLTSESLRQVRALKVDYKEEDSEQEECGMELDLDS---- 171
              ::.::...|:....|||          .::...|:      ||:..:..|||......|
Human   191 SNLVTQEPSPEETSTKRSI----------KQNSNPVK------KEKSCKCNECGKAFSYCSALIR 239

  Fly   172 -EGRHSAKIPHSCPHCTKVYQSRKVLERHIMRQHKDTLSPDVDSEDADY----------EPP--- 222
             :..|:.:.|:.|..|.|.:...:.|..| .|.|         :.|..|          |.|
Human   240 HQRTHTGEKPYKCNECEKAFSRSENLINH-QRIH---------TGDKPYKCDQCGKGFIEGPSLT 294

  Fly   223 KDAPVKSAAQEYKCEHCGKIYHGKYSLRQHLKRDHDNGE------EGGSAI-------------- 267
            :...:.:..:.|||:.|||.:..:..|.|| :|.| .||      |.|.|.
Human   295 QHQRIHTGEKPYKCDECGKAFSQRTHLVQH-QRIH-TGEKPYTCNECGKAFSQRGHFMEHQKIHT 357

  Fly   268 ----FTCLECEAQLPRLRLLDEHMVQAHGGA---ACVVCGRRYKTRHELKRHQLKHTSERNVPCP 325
                |.|.||:....|...|.:|. :.|.|.   .|..||:.:.......||.:.||.|:...|.
Human   358 GEKPFKCDECDKTFTRSTHLTQHQ-KIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYECN 421

  Fly   326 HPGCGKRFFTIRHMRNHGKVHTEQKNFVCESCGYSCRNKETLRVHIRSHTGERPFGCQVCDKRFP 390
            .  |||.|....::..|.|.||.:|.:.|..||.|.....:|..|::.||||:|:.|..|.|.|.
Human   422 E--CGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQHLKIHTGEKPYKCNECGKAFS 484

  Fly   391 SHSGLREHMAMHSTERPHVCSVCGATFSRQKGLYHHKFLHADTKQFVCKLCGNAYAQAAGLAGHM 455
            ..|.|.:|..:|:.|:|..||.||..||....|..|:..|...|.:.||.||.|:.:::.||.|.
Human   485 YCSSLTQHRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHE 549

  Fly   456 RKHRNDE 462
            |.|..::
Human   550 RIHTGEK 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	5/19 (26%)
		zf-C2H2_8	323..411	CDD:292531	31/87 (36%)
		C2H2 Zn finger	327..346	CDD:275368	6/18 (33%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		zf-H2C2_2	367..389	CDD:290200	10/21 (48%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..419	CDD:290200	10/23 (43%)
		C2H2 Zn finger	410..430	CDD:275368	8/19 (42%)
		C2H2 Zn finger	438..458	CDD:275368	9/19 (47%)
ZNF184	NP_001305820.1	KRAB	28..88	CDD:214630
		KRAB	28..67	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..212		4/30 (13%)
		C2H2 Zn finger	224..244	CDD:275368	4/19 (21%)
		zf-H2C2_2	236..261	CDD:290200	5/24 (21%)
		COG5048	<248..409	CDD:227381	41/173 (24%)
		C2H2 Zn finger	252..272	CDD:275368	6/20 (30%)
		zf-H2C2_2	264..287	CDD:290200	6/32 (19%)
		C2H2 Zn finger	280..300	CDD:275368	2/19 (11%)
		zf-H2C2_2	292..317	CDD:290200	6/24 (25%)
		C2H2 Zn finger	308..328	CDD:275368	8/20 (40%)
		zf-H2C2_2	320..345	CDD:290200	10/26 (38%)
		C2H2 Zn finger	336..356	CDD:275368	3/19 (16%)
		zf-H2C2_2	348..373	CDD:290200	4/24 (17%)
		COG5048	360..736	CDD:227381	68/200 (34%)
		C2H2 Zn finger	364..384	CDD:275368	6/20 (30%)
		zf-H2C2_2	376..400	CDD:290200	7/24 (29%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-C2H2	418..440	CDD:278523	7/23 (30%)
		C2H2 Zn finger	420..440	CDD:275368	7/21 (33%)
		zf-H2C2_2	432..457	CDD:290200	9/24 (38%)
		C2H2 Zn finger	448..468	CDD:275368	6/19 (32%)
		zf-H2C2_2	460..485	CDD:290200	11/24 (46%)
		C2H2 Zn finger	476..496	CDD:275368	7/19 (37%)
		zf-H2C2_2	488..513	CDD:290200	10/24 (42%)
		C2H2 Zn finger	504..524	CDD:275368	8/19 (42%)
		zf-H2C2_2	516..541	CDD:290200	9/24 (38%)
		C2H2 Zn finger	532..552	CDD:275368	9/19 (47%)
		zf-H2C2_2	544..569	CDD:290200	5/13 (38%)
		C2H2 Zn finger	560..580	CDD:275368
		zf-H2C2_2	572..597	CDD:290200
		C2H2 Zn finger	588..608	CDD:275368
		zf-H2C2_2	600..625	CDD:290200
		C2H2 Zn finger	616..636	CDD:275368
		zf-H2C2_2	628..653	CDD:290200
		C2H2 Zn finger	644..664	CDD:275368
		zf-H2C2_2	656..681	CDD:290200
		C2H2 Zn finger	672..692	CDD:275368
		zf-H2C2_2	684..709	CDD:290200
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930