DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2129 and ZNF84

DIOPT Version :9

Sequence 1:NP_572449.1 Gene:CG2129 / 31741 FlyBaseID:FBgn0030008 Length:465 Species:Drosophila melanogaster
Sequence 2:NP_001120844.1 Gene:ZNF84 / 7637 HGNCID:13159 Length:738 Species:Homo sapiens


Alignment Length:444 Identity:113/444 - (25%)
Similarity:169/444 - (38%) Gaps:104/444 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   101 GDHNE-DSDD----ERVVLEKQDEDEDERPGRSIIKWQD----------------HQSLTSESLR 144
            ||:.: :|||    :...|..:.||.|     :.:|:.|                |::...|.|.
Human   148 GDYGKAESDDFNVFDNFFLHSKPEDTD-----TWLKYYDCDKYKESYKKSQIIIYHRNRLGEKLY 207

  Fly   145 QVRALKVDYKEEDS---EQE-----------ECGMELDLDSE-----GRHSAKIPHSCPHCTKVY 190
            :....:..:.::.|   .|.           .||......|:     ..|:.:.|::|..|.|.:
Human   208 ECSECRKRFSKKPSLIKHQSRHIRDIAFGCGNCGKTFPQKSQFITHHRTHTGEKPYNCSQCGKAF 272

  Fly   191 QSRKVLERHIMRQHKDTLSPDVDSEDADYEPPKDAPVKS-------------AAQEYKCEHCGKI 242
            ..:..|..| .|.|         :.:..||..:.....|             ..:.|.|..||:.
Human   273 SQKSQLTSH-QRTH---------TGEKPYECGECGKAFSRKSHLISHWRTHTGEKPYGCNECGRA 327

  Fly   243 YHGKYSLRQHLKRDHDNGEEGGSAIFTCLECEAQLPRLRLLDEHMVQAHGGA---ACVVCGRRYK 304
            :..|.:|..| :|.|.     |...|.|.||.....|...|..|. :.|.|.   .|..|.:.:.
Human   328 FSEKSNLINH-QRIHT-----GEKPFECRECGKAFSRKSQLVTHH-RTHTGTKPFGCSDCRKAFF 385

  Fly   305 TRHELKRHQLKHTSERNVPC------------------PHPG--------CGKRFFTIRHMRNHG 343
            .:.||.|||..||.|:...|                  .|.|        |||.|....|:.:|.
Human   386 EKSELIRHQTIHTGEKPYECSECRKAFRERSSLINHQRTHTGEKPHGCIQCGKAFSQKSHLISHQ 450

  Fly   344 KVHTEQKNFVCESCGYSCRNKETLRVHIRSHTGERPFGCQVCDKRFPSHSGLREHMAMHSTERPH 408
            ..||.:|.|:|..||.:...|..|..|.|:||||:|:.|..|.|.|.....|..|..:|:.|:|:
Human   451 MTHTGEKPFICSKCGKAFSRKSQLVRHQRTHTGEKPYECSECGKAFSEKLSLTNHQRIHTGEKPY 515

  Fly   409 VCSVCGATFSRQKGLYHHKFLHADTKQFVCKLCGNAYAQAAGLAGHMRKHRNDE 462
            |||.||..|.::..|..|:..|...|.:.|..||.|:.:.:.||.|.|.|..::
Human   516 VCSECGKAFCQKSHLISHQRTHTGEKPYECSECGKAFGEKSSLATHQRTHTGEK 569

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2129NP_572449.1 C2H2 Zn finger 296..316 CDD:275370 7/19 (37%)
zf-C2H2_8 323..411 CDD:292531 35/113 (31%)
C2H2 Zn finger 327..346 CDD:275368 7/26 (27%)
C2H2 Zn finger 354..374 CDD:275368 7/19 (37%)
zf-H2C2_2 367..389 CDD:290200 11/21 (52%)
C2H2 Zn finger 382..402 CDD:275368 6/19 (32%)
zf-H2C2_2 395..419 CDD:290200 11/23 (48%)
C2H2 Zn finger 410..430 CDD:275368 7/19 (37%)
C2H2 Zn finger 438..458 CDD:275368 8/19 (42%)
ZNF84NP_001120844.1 KRAB 9..68 CDD:214630
C2H2 Zn finger 209..229 CDD:275368 2/19 (11%)
C2H2 Zn finger 237..257 CDD:275368 3/19 (16%)
C2H2 Zn finger 265..285 CDD:275368 6/20 (30%)
zf-H2C2_2 278..302 CDD:316026 6/33 (18%)
C2H2 Zn finger 293..313 CDD:275368 1/19 (5%)
COG5048 317..724 CDD:227381 82/260 (32%)
C2H2 Zn finger 321..341 CDD:275368 7/20 (35%)
C2H2 Zn finger 349..369 CDD:275368 6/20 (30%)
C2H2 Zn finger 377..397 CDD:275368 7/19 (37%)
C2H2 Zn finger 405..425 CDD:275368 1/19 (5%)
C2H2 Zn finger 433..453 CDD:275368 6/19 (32%)
C2H2 Zn finger 461..481 CDD:275368 7/19 (37%)
C2H2 Zn finger 489..509 CDD:275368 6/19 (32%)
C2H2 Zn finger 517..537 CDD:275368 7/19 (37%)
C2H2 Zn finger 545..565 CDD:275368 8/19 (42%)
C2H2 Zn finger 573..593 CDD:275368
C2H2 Zn finger 601..621 CDD:275368
C2H2 Zn finger 629..649 CDD:275368
C2H2 Zn finger 657..677 CDD:275368
C2H2 Zn finger 685..705 CDD:275368
C2H2 Zn finger 713..733 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142188
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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