DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and ZNF747

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001291947.1	Gene:	ZNF747 / 65988	HGNCID:	28350	Length:	331	Species:	Homo sapiens

Alignment Length:	147	Identity:	53/147 - (36%)
Similarity:	64/147 - (43%)	Gaps:	14/147 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   313 QLKHTSERNVPCPHPGCGKRFFTIRHMRNHGKVHTEQKNFVCESCGYSCRNKETLRVHIRSHTGE 377
            ||.....|:.|        |||.      |..|....:...|..||.|...:.||..||.||.||
Human   157 QLSKARRRSRP--------RFFA------HPPVPRADQRHGCYVCGKSFAWRSTLVEHIYSHRGE 207

  Fly   378 RPFGCQVCDKRFPSHSGLREHMAMHSTERPHVCSVCGATFSRQKGLYHHKFLHADTKQFVCKLCG 442
            :||.|..|.|.|...|.|.:|.|:|..||||.|..||..|.|:..|..|..:|...|.:.|..||
Human   208 KPFHCADCGKGFGHASSLSKHRAIHRGERPHRCPECGRAFMRRTALTSHLRVHTGEKPYRCPQCG 272

  Fly   443 NAYAQAAGLAGHMRKHR 459
            ..:....|:|.|...||
Human   273 RCFGLKTGMAKHQWVHR 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	2/2 (100%)
		zf-C2H2_8	323..411	CDD:292531	33/87 (38%)
		C2H2 Zn finger	327..346	CDD:275368	4/18 (22%)
		C2H2 Zn finger	354..374	CDD:275368	8/19 (42%)
		zf-H2C2_2	367..389	CDD:290200	12/21 (57%)
		C2H2 Zn finger	382..402	CDD:275368	8/19 (42%)
		zf-H2C2_2	395..419	CDD:290200	12/23 (52%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
ZNF747	NP_001291947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		KRAB	37..96	CDD:214630
		KRAB	37..76	CDD:279668
		C2H2 Zn finger	184..204	CDD:275368	8/19 (42%)
		zf-H2C2_2	197..219	CDD:290200	12/21 (57%)
		C2H2 Zn finger	212..232	CDD:275368	8/19 (42%)
		zf-H2C2_2	224..247	CDD:290200	11/22 (50%)
		COG5048	236..>273	CDD:227381	14/36 (39%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		zf-H2C2_2	252..275	CDD:290200	7/22 (32%)
		C2H2 Zn finger	268..288	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142307
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930