DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2129 and ZNF302

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_016882467.1	Gene:	ZNF302 / 55900	HGNCID:	13848	Length:	444	Species:	Homo sapiens

Alignment Length:	359	Identity:	88/359 - (24%)
Similarity:	147/359 - (40%)	Gaps:	45/359 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 EDSDDERVVLEKQDEDEDERPGRSIIKWQDHQSLTSESL---------RQVRALKVDYKEEDS-- 158
            ||..:..::.:|..:|.:.|       |::.:..|.:.:         ...:.:|..|:..:|
Human   102 EDGKEPWMMEKKLSKDWESR-------WENKELSTKKDIYDEDSPQPVTMEKVVKQSYEFSNSNK 159

  Fly   159 --EQEECG-------MELDLDSEGRHSAK-IPHSCPHCTKVYQSRKVLERHIMRQHKDTLSPDVD 213
              |..||.       .:..|.....:||: ..|......|....:.|::...:...|..|:.  :
Human   160 NLEYTECDTFRSTFHSKSTLSEPQNNSAEGNSHKYDILKKNLSKKSVIKSERINGGKKLLNS--N 222

  Fly   214 SEDADYEPPKDAPVKSAAQE---YKCEHCGKIYHGKYSLRQHLKRDHDNGEEGGSAIFTCLECEA 275
            ...|.:...|...:......   |.|..|||.: ||.|:.....|.|.     |...:.|.||..
Human   223 KSGAAFNQSKSLTLPQTCNREKIYTCSECGKAF-GKQSILSRHWRIHT-----GEKPYECRECGK 281

  Fly   276 QLPRLRLLDEHMVQAHGGA---ACVVCGRRYKTRHELKRHQLKHTSERNVPCPHPGCGKRFFTIR 337
            .......|..|.: :|.|.   .|:.||:.:.....|..||..||.|:...|.:  |||.|..:.
Human   282 TFSHGSSLTRHQI-SHSGEKPYKCIECGKAFSHGSSLTNHQSTHTGEKPYECMN--CGKSFSRVS 343

  Fly   338 HMRNHGKVHTEQKNFVCESCGYSCRNKETLRVHIRSHTGERPFGCQVCDKRFPSHSGLREHMAMH 402
            .:..|.::||::|.:.|..||.:..:..:|..|.:|||||:|:.|:.|.|.|...|.|.:|..:|
Human   344 LLIQHLRIHTQEKRYECRICGKAFIHSSSLIHHQKSHTGEKPYECRECGKAFCCSSHLTQHQRIH 408

  Fly   403 STERPHVCSVCGATFSRQKGLYHHKFLHADTKQF 436
            |.::.:.|:.|...||....|..|:.:|.:.|.|
Human   409 SMKKKYECNKCLKVFSSFSFLVQHQSIHTEEKPF 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	6/19 (32%)
		zf-C2H2_8	323..411	CDD:292531	29/87 (33%)
		C2H2 Zn finger	327..346	CDD:275368	5/18 (28%)
		C2H2 Zn finger	354..374	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..389	CDD:290200	11/21 (52%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..419	CDD:290200	7/23 (30%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368
ZNF302	XP_016882467.1	KRAB	48..109	CDD:214630	2/6 (33%)
		COG5048	<151..393	CDD:227381	64/252 (25%)
		C2H2 Zn finger	248..268	CDD:275368	8/20 (40%)
		C2H2 Zn finger	276..296	CDD:275368	5/20 (25%)
		C2H2 Zn finger	304..324	CDD:275368	6/19 (32%)
		C2H2 Zn finger	332..352	CDD:275368	6/21 (29%)
		C2H2 Zn finger	360..380	CDD:275368	5/19 (26%)
		C2H2 Zn finger	388..408	CDD:275368	7/19 (37%)
		C2H2 Zn finger	416..436	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930