DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and ZNF107

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	561	Identity:	129/561 - (22%)
Similarity:	197/561 - (35%)	Gaps:	160/561 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KPDTYAGMANAKCGEIYFQSLHSFRIDCAFCEMKSFVFGDFLLHVQNI-HFENGLLKTEATDAGA 69
            ||..|     .:||:::.||.|                    |..|.| |....|.|.:......
Human   327 KPYKY-----EECGKVFSQSSH--------------------LTTQKILHTGENLYKCKECGKAF 366

  Fly    70 NLKQERDREREPNSPVPIVAQVNPFAWYEIGGDHNEDSDDERVVLEKQDEDEDERPGRSIIKWQD 134
            ||.......:.      |.|...|:...|.|...|..|:     |.||   |....|..:.|.::
Human   367 NLFSNLTNHKR------IHAGEKPYKCKECGRAFNISSN-----LNKQ---EKIHTGGKLNKCEE 417

  Fly   135 HQSLTSESLRQVRALKVDYKEEDSEQEECGMELDLDS-----EGRHSAKIPHSCPHCTKVYQSRK 194
            .....:.||:.....|:..:|:..:.||||...:..|     :..|:.:.|:.|..|.|.:....
Human   418 CDKAFNRSLKLTAHKKILMEEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPYKCKECGKAFNQSS 482

  Fly   195 VLERH-----------------IMRQHKDTLSPDVDSEDADYEPPKDAPVKSAAQEYKCEHCGKI 242
            .|..|                 ...||.:.::              ...:.|..:.||||.|||.
Human   483 NLTEHKKIHTAEKSYKCEECGKAFNQHSNLIN--------------HRKIYSGEKPYKCEECGKA 533

  Fly   243 YHGKYSLRQHLKRDHDNGEE------------------------GGSAIFTCLECEAQLPRLRLL 283
            ::...:|.:| |:.| .||:                        .|...:.|.||.....|...|
Human   534 FNRSSTLTRH-KKIH-TGEKPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKCEECGKAFNRFSTL 596

  Fly   284 DEHMVQAHGGA---ACVVCGRRYKTRHELKRHQLKHTSERNVPCP------------------HP 327
            .:|. :.|.|.   .|..||:.:...::|.||::.||.|:...|.                  |.
Human   597 TKHK-RIHTGEKPYKCEECGKAFNQSYQLTRHKIVHTKEKLNKCEEFGKAFKQSSHRTIHKIIHT 660

  Fly   328 G-----C-------------------------------GKRFFTIRHMRNHGKVHTEQKNFVCES 356
            |     |                               ||.|....::.||..::|.:|...||.
Human   661 GEKPYKCEEHGKVFNQSSNLTTQKIIHTGENLYKFEEHGKAFNLFSNITNHKIIYTGEKPHKCEE 725

  Fly   357 CGYSCRNKETLRVHIRSHTGERPFGCQVCDKRFPSHSGLREHMAMHSTERPHVCSVCGATFSRQK 421
            ||.:......|.:|.|.||||:|:.|..|.|.|...|.|..|..:|:.|:|:.|..||..|:...
Human   726 CGKAYNRFSNLTIHKRIHTGEKPYQCAECGKAFNCSSTLNRHKIIHTGEKPYKCKECGKAFNLSS 790

  Fly   422 GLYHHKFLHADTKQFVCKLCGNAYAQAAGLAGHMRKHRNDE 462
            .|..||.:|...|.:.|:.||.|:.|::.|..|.:.|.:::
Human   791 TLTAHKKIHTGEKPYKCEECGKAFNQSSNLTTHKKIHTSEK 831

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	6/19 (32%)
		zf-C2H2_8	323..411	CDD:292531	33/141 (23%)
		C2H2 Zn finger	327..346	CDD:275368	7/54 (13%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..389	CDD:290200	11/21 (52%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..419	CDD:290200	9/23 (39%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368
		C2H2 Zn finger	219..239	CDD:275368
		COG5048	243..621	CDD:227381	73/349 (21%)
		C2H2 Zn finger	247..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368
		C2H2 Zn finger	331..351	CDD:275368	9/44 (20%)
		C2H2 Zn finger	359..379	CDD:275368	2/25 (8%)
		C2H2 Zn finger	387..407	CDD:275368	8/27 (30%)
		C2H2 Zn finger	415..435	CDD:275368	3/19 (16%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
		C2H2 Zn finger	471..491	CDD:275368	5/19 (26%)
		C2H2 Zn finger	499..519	CDD:275368	2/33 (6%)
		C2H2 Zn finger	527..547	CDD:275368	8/20 (40%)
		COG5048	551..>863	CDD:227381	68/282 (24%)
		C2H2 Zn finger	555..575	CDD:275368	0/19 (0%)
		C2H2 Zn finger	583..603	CDD:275368	6/20 (30%)
		C2H2 Zn finger	611..631	CDD:275368	6/19 (32%)
		C2H2 Zn finger	639..659	CDD:275368	1/19 (5%)
		C2H2 Zn finger	699..715	CDD:275368	5/15 (33%)
		C2H2 Zn finger	723..743	CDD:275368	7/19 (37%)
		C2H2 Zn finger	751..771	CDD:275368	7/19 (37%)
		C2H2 Zn finger	779..799	CDD:275368	7/19 (37%)
		C2H2 Zn finger	807..827	CDD:275368	7/19 (37%)
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142210
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930