DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and CG11902

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_651389.3	Gene:	CG11902 / 43070	FlyBaseID:	FBgn0028647	Length:	1426	Species:	Drosophila melanogaster

Alignment Length:	497	Identity:	109/497 - (21%)
Similarity:	186/497 - (37%)	Gaps:	110/497 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SLKPDTYAGMANAKCGE----------------IYFQSLHSFRIDCAFCEMKSFVFGDFLLH--- 49
            |::.|......:.:||:                ::.|..:.||  |.:|..:.:...:.|.|
  Fly   953 SIQDDLPKVDGDLQCGKCNRSFRMQKDLTRHTLMHGQESNIFR--CRWCARRFYRRANLLQHIAR 1015

  Fly    50 ----VQNIHFENGLLKTEATDAGANLKQERDREREPNSPVPIVAQVNPFAWYEIGGDHNEDSDDE 110
                |..:.:...:|.:.....|    :::...|..|...|.:|.:.........|.|::.|..:
  Fly  1016 HGISVSQLPYAEAILDSYVNPGG----RKKVECRVCNVSFPTIAALRLHLETMPAGSHHDYSSLQ 1076

  Fly   111 RVVLEKQ--------DEDEDERPGRSIIKWQDHQSLTSESLRQVRALKVDYKEEDSEQEECGMEL 167
            ...:..|        |.:.|:...|:.||.....|..:.::.|:|.|:   |.|..:.::....:
  Fly  1077 NYSITNQMGFEMDLYDSETDDEDSRTHIKPPGAPSSYTCNMCQLRCLR---KFELYQHQQAMHRM 1138

  Fly   168 DLDSEGRHSAKIPHSCPHCTKVYQSRKVLERHIMRQHKDTLSPDVDSEDADYEPPKDAPVKSAAQ 232
            :..|:|..|......||              .|:..||.|                  ..::..:
  Fly  1139 EKISDGCDSCLFKSVCP--------------EIISHHKRT------------------QCENREK 1171

  Fly   233 EYKCEHCGKIYHGKYSLRQHLKRDHDNGEEGGSAIFTCLECEAQLPRLRLLDEHMVQAHGGA--- 294
            ::||..||..:..:.:|..|:...|...|:                  :.|||.. :|.|..
  Fly  1172 QFKCTRCGYKFMWESNLLLHMDLQHVKTED------------------QELDESK-EASGDEPKT 1217

  Fly   295 -----ACVVCGRRYKTRHELKRHQLKHTSERNVPCPHPGCGKRFFTIRHMRNHGKVHTEQKNFVC 354
                 .|.:|.|:|..:..|..|..|.    :.|...|...|       ..|......|.|.|:|
  Fly  1218 EGQVFQCGLCTRKYNRKDRLTAHLKKF----HGPDCKPSTAK-------TPNRPISPKEPKRFLC 1271

  Fly   355 ESCGYSCRNKETLRVHIRSHTGERPFGCQVCDKRFPSHSGLREHMAMHSTERPHVCSVCGATFSR 419
            ..||.:..:...|.:|:|.||||:||.|:.|...||..|.|:.|...|:.||||||:||...|:|
  Fly  1272 AFCGKAVSSSSNLIIHMRRHTGEKPFKCEYCTMAFPRSSDLQCHRRTHTGERPHVCTVCQKGFAR 1336

  Fly   420 QKGLYHHKFLHADTKQFVCKLCGNAYAQAAGLAGHMRKHRND 461
            ...|..|..:|:..:.:.|..|..::.|:..|..|:|:|..:
  Fly  1337 SYKLQQHMRIHSGERPYKCTYCEKSFTQSNDLTLHIRRHTGE 1378

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	6/19 (32%)
		zf-C2H2_8	323..411	CDD:292531	32/87 (37%)
		C2H2 Zn finger	327..346	CDD:275368	3/18 (17%)
		C2H2 Zn finger	354..374	CDD:275368	6/19 (32%)
		zf-H2C2_2	367..389	CDD:290200	11/21 (52%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..419	CDD:290200	12/23 (52%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
CG11902	NP_651389.3	zf-AD	6..83	CDD:285071
		C2H2 Zn finger	208..228	CDD:275368
		C2H2 Zn finger	236..256	CDD:275368
		C2H2 Zn finger	384..405	CDD:275368
		C2H2 Zn finger	417..437	CDD:275368
		C2H2 Zn finger	447..463	CDD:275368
		C2H2 Zn finger	578..599	CDD:275368
		C2H2 Zn finger	610..629	CDD:275368
		C2H2 Zn finger	640..660	CDD:275368
		C2H2 Zn finger	676..696	CDD:275368
		C2H2 Zn finger	706..726	CDD:275368
		C2H2 Zn finger	762..782	CDD:275368
		C2H2 Zn finger	866..887	CDD:275368
		C2H2 Zn finger	896..918	CDD:275368
		C2H2 Zn finger	926..947	CDD:275368
		C2H2 Zn finger	967..987	CDD:275368	2/19 (11%)
		C2H2 Zn finger	996..1016	CDD:275368	4/19 (21%)
		C2H2 Zn finger	1044..1063	CDD:275368	4/18 (22%)
		C2H2 Zn finger	1224..1244	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1271..1291	CDD:275368	6/19 (32%)
		zf-H2C2_2	1283..1306	CDD:290200	11/22 (50%)
		COG5048	1295..>1367	CDD:227381	26/71 (37%)
		C2H2 Zn finger	1299..1319	CDD:275368	7/19 (37%)
		zf-H2C2_2	1311..1336	CDD:290200	12/24 (50%)
		C2H2 Zn finger	1327..1347	CDD:275368	7/19 (37%)
		zf-H2C2_2	1340..1364	CDD:290200	5/23 (22%)
		C2H2 Zn finger	1355..1375	CDD:275368	6/19 (32%)
		zf-H2C2_2	1367..1392	CDD:290200	4/12 (33%)
		C2H2 Zn finger	1383..1401	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010