DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2129 and CG12942

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_610628.2	Gene:	CG12942 / 36158	FlyBaseID:	FBgn0033569	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	370	Identity:	80/370 - (21%)
Similarity:	135/370 - (36%)	Gaps:	99/370 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 DDERVVLEKQDEDEDERPGRSIIKWQDHQSLTSESLRQVRALKVDYKEEDSEQE-ECGMELDLDS 171
            :|:.:.|.|...          .|.:...|..::...:::...:|:.:.|.:.| .|.|:.
  Fly   333 EDDIIGLNKNQN----------FKCRPCNSYETKDRSEMQKHLIDHHKIDGDFEMYCYMQA---- 383

  Fly   172 EGRHSAKIPHSCPHCTKVYQSRKVLERHIMRQHKDTLSPDVDSEDADYEPPKDAPVK---SAAQE 233
                      :||.|.::::.::...:|..|.|                    .||:   |..:.
  Fly   384 ----------NCPACDRIFKDQRSARKHYTRVH--------------------TPVQIAVSPTES 418

  Fly   234 YKCEHCGKIYHGKYSLRQHLK----RDHDNGEEGGSAIFTCLECEAQLPRLRLLDEHMVQAHGGA 294
            |.|..|.|:::.|.||..|.:    :|          :..|..|:.|...:|..:.|:.|.|...
  Fly   419 YACTACDKVFNQKASLHSHQRFCQVKD----------VVHCSFCDQQFNSMRKYELHLQQLHAVE 473

  Fly   295 A---CVVCGRRYKTRHELKRHQLKHTSERNVPCPHPGCGKRFFTIRHMRNHGKVHTEQKNFVCES 356
            .   |.:|.|.:|:...|..|:.:| |||     |..|||
  Fly   474 TVHECEICRRSFKSAETLTMHRKRH-SER-----HYQCGK------------------------- 507

  Fly   357 CGYSCRNKETLRVHI-RSHTGERPFGCQVCDKRFPSHSGLREH-MAMHSTERPHVCSVCGATFSR 419
            |..:..|...||||. |:|..|.|..|..|..:|.:.:.|||| ...|...:...|.||......
  Fly   508 CSLNYVNSAELRVHYERAHVNEEPVSCLTCGNQFQNMTLLREHEQRSHQKSKVWRCEVCNFETKT 572

  Fly   420 QKGLYHHKFLHADTKQFVCKLCGNAYAQAAGLAGHMRKHRNDELN 464
            :.....|::.|.| ..:.|:.|.:.:|..:....|.:|....||:
  Fly   573 RWRRRQHQYEHMD-YPYKCQKCTSEFADRSKFRQHSKKVHGIELS 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	6/19 (32%)
		zf-C2H2_8	323..411	CDD:292531	22/89 (25%)
		C2H2 Zn finger	327..346	CDD:275368	3/18 (17%)
		C2H2 Zn finger	354..374	CDD:275368	7/20 (35%)
		zf-H2C2_2	367..389	CDD:290200	10/22 (45%)
		C2H2 Zn finger	382..402	CDD:275368	7/20 (35%)
		zf-H2C2_2	395..419	CDD:290200	8/24 (33%)
		C2H2 Zn finger	410..430	CDD:275368	4/19 (21%)
		C2H2 Zn finger	438..458	CDD:275368	4/19 (21%)
CG12942	NP_610628.2	zf-AD	22..101	CDD:285071
		C2H2 Zn finger	385..406	CDD:275368	5/20 (25%)
		C2H2 Zn finger	421..470	CDD:275368	14/58 (24%)
		C2H2 Zn finger	449..466	CDD:275371	4/16 (25%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	505..526	CDD:275368	10/45 (22%)
		C2H2 Zn finger	534..555	CDD:275368	7/20 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440082
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930