DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and Zfp553

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001347841.1	Gene:	Zfp553 / 233887	MGIID:	2384725	Length:	591	Species:	Mus musculus

Alignment Length:	549	Identity:	119/549 - (21%)
Similarity:	171/549 - (31%)	Gaps:	164/549 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 NGLLKTEATDAGANLKQERD--REREPNSPVPIVAQVNPFAW-----------YEIGGDHNEDSD 108
            |..||.:......:|...|:  .:|:|..|||.:  :....|           .|.|....:.||
Mouse    35 NTSLKPDGIQCWDDLWDRREGLGKRQPRDPVPRI--LGEPRWGQGSNDRAAVCGECGKSFRQMSD 97

  Fly   109 DERVVLEKQDEDEDERP----------GRSIIKWQDHQSLTSESLRQVR----------ALKVDY 153
                :::.|.....|:|          |.|..:.:..::.|.|...:||          ..::..
Mouse    98 ----LVKHQRTHTGEKPYKCGVCGKGFGDSSARIKHQRTHTGEKAYRVRPPAPGPPKMPRSRIPA 158

  Fly   154 KEEDSEQEECGMEL----DLDSEGR-HSAKIPHSCPHCTKVYQSRKVLERHIMRQHK-DTL-SPD 211
            .|..:...|||...    ||....| |:.:.|:.|..|.|.:.......:| .|.|: |.| .|.
Mouse   159 GERPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGFGDSSARIKH-QRTHRGDQLPRPV 222

  Fly   212 VDSEDADYEPPKDAPVKSAAQE--YKCEHCGKIYHGKYSLRQHLKRDHDNGEEGGSAIFTCLECE 274
            |.........|. ||.:..||:  |.|..|||.:....||..| :|.|     .|...|.|..|.
Mouse   223 VPRRQPSPAAPA-APHRPKAQDKPYICTDCGKRFVLSCSLLSH-QRSH-----LGPKPFGCDVCG 280

  Fly   275 AQLPRLRLLDEHMVQAHGGA---ACVVCGRRYKTRHELKRHQLKHTSERNVPCPHPGCGKRFFTI 336
            .:..|...|.:|: :.|.|.   .|..||:.:.......:|...|:.:|...||.  |.:.|...
Mouse   281 KEFARGSDLVKHL-RVHTGEKPYLCPECGKGFADSSARVKHLRTHSGQRPHACPE--CNRSFSLS 342

  Fly   337 RHMRNHGKVHTEQKNF------------------------------------------------- 352
            ..:..|...|.|.::|
Mouse   343 STLLRHRLTHVEPQDFSLAAYPVVPLIPSPPPPPLGTSPSLTPRSPSHSSDGPFGLPGLEPEPGG 407

  Fly   353 ----------------VCESCGYSCRNKETLRVHIRSHTGERPFGCQVCDKRFPSHSGLREHMAM 401
                            .|..||...|....|..|.|.||||:|:.|..|.|.|...|...:|:..
Mouse   408 PQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSARVKHLRT 472

  Fly   402 HSTERP-------------------------------------HVCSVCGATFSRQKGLYHHKFL 429
            |..||.                                     |||..||..|.|...|..|:..
Mouse   473 HQGERTRPPPPPSTLLRPHNPPGSVPIVPQSRVQGRPSGPSQLHVCGFCGKEFPRSSDLVKHRRT 537

  Fly   430 HADTKQFVCKLCGNAYAQAAGLAGHMRKH 458
            |...|.:.|..||..:..::....|.|.|
Mouse   538 HTGEKPYKCAECGKGFGDSSARIKHQRGH 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	4/19 (21%)
		zf-C2H2_8	323..411	CDD:292531	31/189 (16%)
		C2H2 Zn finger	327..346	CDD:275368	3/18 (17%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..389	CDD:290200	11/21 (52%)
		C2H2 Zn finger	382..402	CDD:275368	6/19 (32%)
		zf-H2C2_2	395..419	CDD:290200	10/60 (17%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	5/19 (26%)
Zfp553	NP_001347841.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	55..80		6/26 (23%)
		C2H2 Zn finger	85..105	CDD:275368	5/23 (22%)
		zf-H2C2_2	97..120	CDD:316026	4/26 (15%)
		C2H2 Zn finger	113..133	CDD:275368	2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	131..160		4/28 (14%)
		COG5048	161..572	CDD:227381	94/417 (23%)
		C2H2 Zn finger	165..185	CDD:275368	6/19 (32%)
		C2H2 Zn finger	193..213	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	206..241		10/36 (28%)
		C2H2 Zn finger	248..268	CDD:275368	8/20 (40%)
		C2H2 Zn finger	276..296	CDD:275368	5/20 (25%)
		C2H2 Zn finger	304..324	CDD:275368	4/19 (21%)
		C2H2 Zn finger	332..352	CDD:275368	5/21 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..429		1/56 (2%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..538	CDD:275368	18/84 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..512		5/47 (11%)
		C2H2 Zn finger	546..566	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	564..591		2/3 (67%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930