DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and ZNF48

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001201835.1	Gene:	ZNF48 / 197407	HGNCID:	13114	Length:	618	Species:	Homo sapiens

Alignment Length:	525	Identity:	116/525 - (22%)
Similarity:	169/525 - (32%)	Gaps:	172/525 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 RDREREPN-------SPVPIVAQVNPFAWYEIGGDHNEDSDDERVVLEKQDEDEDERPGRSIIK- 131
            |..||||.       ....:::|.|.|       :|....||  :..:::|...|...|.:.:|
Human    14 RPEEREPQRGARTGLGSENVISQPNEF-------EHTPQEDD--LGFKEEDLAPDHEVGNASLKP 69

  Fly   132 ---------WQDHQSLTSESLRQ--VRAL-KVDYKEEDSEQE----ECGMEL----DLDSEGR-H 175
                     |...:.|.....|.  .|.| :..:.:..|::.    |||...    ||....| |
Human    70 EGIQNWDDLWVQREGLGKPQPRDRGPRLLGEPRWGQASSDRAAVCGECGKSFRQMSDLVKHQRTH 134

  Fly   176 SAKIPHSCPHCTKVYQSRKVLERHIMRQHKDTLSPDVDSEDADY--EPPKDAPVK---------- 228
            :.:.|:.|..|.|.:.......:| .|.|         |.:..|  .||...|.|
Human   135 TGEKPYKCGVCGKGFGDSSARIKH-QRTH---------SGEKPYRARPPAQGPPKIPRSRIPAGE 189

  Fly   229 -------------------------SAAQEYKCEHCGKIYHGKYSLRQHLKRDHDNGEEGGSAIF 268
                                     :..:.|||..|||.: |..|.|...:|.| .||:....:
Human   190 RPTICGECGKSFRQSSDLVKHQRTHTGEKPYKCGICGKGF-GDSSARIKHQRTH-RGEQPPRPV- 251

  Fly   269 TCLECEAQLPRLRLLDEHMVQAHGGAA------CVVCGRRYKTRHELKRHQLKHTSERNVPCPHP 327
                    :||.:..........|..|      |..||:|:.....|..||..|...:...|  .
Human   252 --------VPRRQPSRAATAATQGPKAQDKPYICTDCGKRFVLSCSLLSHQRSHLGPKPFGC--D 306

  Fly   328 GCGKRFFTIRHMRNHGKVHTEQKNFVCESCGYSCRNKETLRVHIRSHTGERPFGCQVCDKRF--- 389
            .|||.|.....:..|.:|||.:|.::|..||....:......|:|:|:||||..|..||:.|
Human   307 VCGKEFARGSDLVKHLRVHTGEKPYLCPECGKGFADSSARVKHLRTHSGERPHACPECDRTFSLS 371

  Fly   390 ---------------------------------------------PSHSGLREHMAMHSTE---- 405
                                                         |||||  |...:...|
Human   372 STLLRHRLTHMEPQDFSFPGYPLPALIPSPPPPPLGTSPPLTPRSPSHSG--EPFGLPGLEPEPG 434

  Fly   406 --------------RPHVCSVCGATFSRQKGLYHHKFLHADTKQFVCKLCGNAYAQAAGLAGHMR 456
                          :||.|..||..|.|...|..|..:|...|.::|..||..:|.::....|:|
Human   435 GPQAGEPPPPLAGDKPHKCPECGKGFRRSSDLVKHHRVHTGEKPYLCPECGKGFADSSARVKHLR 499

  Fly   457 KHRND 461
            .||.:
Human   500 THRGE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	7/19 (37%)
		zf-C2H2_8	323..411	CDD:292531	33/153 (22%)
		C2H2 Zn finger	327..346	CDD:275368	5/18 (28%)
		C2H2 Zn finger	354..374	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..389	CDD:290200	10/21 (48%)
		C2H2 Zn finger	382..402	CDD:275368	10/67 (15%)
		zf-H2C2_2	395..419	CDD:290200	8/41 (20%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	6/19 (32%)
ZNF48	NP_001201835.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51		11/45 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	78..109		5/30 (17%)
		zf-C2H2	113..134	CDD:278523	6/20 (30%)
		COG5048	114..499	CDD:227381	92/409 (22%)
		C2H2 Zn finger	114..134	CDD:275368	6/19 (32%)
		zf-H2C2_2	126..149	CDD:290200	8/22 (36%)
		C2H2 Zn finger	142..162	CDD:275368	5/20 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..189		9/41 (22%)
		C2H2 Zn finger	194..214	CDD:275368	0/19 (0%)
		zf-C2H2	194..214	CDD:278523	0/19 (0%)
		zf-H2C2_2	206..229	CDD:290200	6/22 (27%)
		C2H2 Zn finger	222..242	CDD:275368	8/20 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..271		8/45 (18%)
		C2H2 Zn finger	277..297	CDD:275368	7/19 (37%)
		C2H2 Zn finger	305..325	CDD:275368	6/21 (29%)
		zf-H2C2_2	317..341	CDD:290200	8/23 (35%)
		C2H2 Zn finger	333..353	CDD:275368	5/19 (26%)
		zf-H2C2_2	348..369	CDD:290200	10/20 (50%)
		C2H2 Zn finger	361..381	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..457		10/66 (15%)
		zf-C2H2	451..473	CDD:278523	8/21 (38%)
		C2H2 Zn finger	453..473	CDD:275368	7/19 (37%)
		zf-H2C2_2	465..489	CDD:290200	7/23 (30%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	500..540		2/5 (40%)
		COG5048	524..>591	CDD:227381
		zf-C2H2	543..565	CDD:278523
		C2H2 Zn finger	545..565	CDD:275368
		zf-H2C2_2	557..580	CDD:290200
		C2H2 Zn finger	573..593	CDD:275370
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142445
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930