DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and ZNF785

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	XP_011544054.1	Gene:	ZNF785 / 146540	HGNCID:	26496	Length:	418	Species:	Homo sapiens

Alignment Length:	352	Identity:	86/352 - (24%)
Similarity:	134/352 - (38%)	Gaps:	76/352 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   125 PGRSIIKWQDHQSLTSESLRQVRALKVDYKEEDSEQ---------EECGMELDLDSEGRHSAKIP 180
            |..:.|.|.:         .:|.|...:.::.|.|.         :|.|     ..:|....:..
Human    86 PKPAFISWVE---------GEVEAWSPEAQDPDGESSAAFSRGQGQEAG-----SRDGNEEKERL 136

  Fly   181 HSCPHCTKVYQSRKVLERHIMRQHKDTLSPDVDSEDADYEPPKDAPVKSAAQE-------YKCEH 238
            ..||...:|.....|.|          ..|.|..  .::..|:.:|:....::       :.|..
Human   137 KKCPKQKEVAHEVAVKE----------WWPSVAC--PEFCNPRQSPMNPWLKDTLTRRLPHSCPD 189

  Fly   239 CGKIYHGKYSLRQHLKRDHDNGEEGGSAIFTCLECEAQLPRLRLLDEHMVQAHGGAACVVCGRRY 303
            ||:.:.....|..| :|.|     .|...|:|.:|:|                          |:
Human   190 CGRNFSYPSLLASH-QRVH-----SGERPFSCGQCQA--------------------------RF 222

  Fly   304 KTRHELKRHQLKHTSERNVPCPHPGCGKRFFTIRHMRNHGKVHTEQKNFVCESCGYSCRNKETLR 368
            ..|..|.:||..||.|:..||  |.||:||.....:..|.:.||.:|.:.|..|.........|.
Human   223 SQRRYLLQHQFIHTGEKPYPC--PDCGRRFRQRGSLAIHRRAHTGEKPYACSDCKSRFTYPYLLA 285

  Fly   369 VHIRSHTGERPFGCQVCDKRFPSHSGLREHMAMHSTERPHVCSVCGATFSRQKGLYHHKFLHADT 433
            :|.|.||||:|:.|..|..||...|.|..|..:|:.|:|:.|..||..|:....|..|:.:|:|:
Human   286 IHQRKHTGEKPYSCPDCSLRFAYTSLLAIHRRIHTGEKPYPCPDCGRRFTYSSLLLSHRRIHSDS 350

  Fly   434 KQFVCKLCGNAYAQAAGLAGHMRKHRN 460
            :.|.|..||..:.:...|..|...||:
Human   351 RPFPCVECGKGFKRKTALEAHRWIHRS 377

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	5/19 (26%)
		zf-C2H2_8	323..411	CDD:292531	31/87 (36%)
		C2H2 Zn finger	327..346	CDD:275368	6/18 (33%)
		C2H2 Zn finger	354..374	CDD:275368	5/19 (26%)
		zf-H2C2_2	367..389	CDD:290200	10/21 (48%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..419	CDD:290200	9/23 (39%)
		C2H2 Zn finger	410..430	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..458	CDD:275368	5/19 (26%)
ZNF785	XP_011544054.1	KRAB	29..102	CDD:214630	5/24 (21%)
		COG5048	<156..372	CDD:227381	68/251 (27%)
		C2H2 Zn finger	187..207	CDD:275368	6/20 (30%)
		C2H2 Zn finger	215..235	CDD:275368	8/45 (18%)
		C2H2 Zn finger	243..263	CDD:275368	7/21 (33%)
		C2H2 Zn finger	271..291	CDD:275368	5/19 (26%)
		C2H2 Zn finger	299..319	CDD:275368	7/19 (37%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		C2H2 Zn finger	355..375	CDD:275368	5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930