DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2129 and ZNF729

DIOPT Version :9

Sequence 1:	NP_572449.1	Gene:	CG2129 / 31741	FlyBaseID:	FBgn0030008	Length:	465	Species:	Drosophila melanogaster
Sequence 2:	NP_001229609.1	Gene:	ZNF729 / 100287226	HGNCID:	32464	Length:	1252	Species:	Homo sapiens

Alignment Length:	397	Identity:	107/397 - (26%)
Similarity:	169/397 - (42%)	Gaps:	60/397 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    93 PFAWYEIGGDHNEDSD--DERVVLEKQDEDEDERPGRSIIKWQDHQSLTSESLRQVRALKVDYKE 155
            |:...|.|...::.|.  ...::...:...:.|..|:: .||     |:..::.:|    :...|
Human   851 PYKCEECGKAFSQSSSLRKHEIIHSGEKPYKCEECGKA-FKW-----LSKLTVHKV----IHTAE 905

  Fly   156 EDSEQEECGMELDLDSEGR-----HSAKIPHSCPHCTKVYQSRKVLERH-IMRQHKDTLSPDVDS 214
            :..:.||||......|..|     |:.|.|:.|..|.|.:.....|.:| |:...|
Human   906 KPCKCEECGKAFKHFSALRKHKIIHTGKKPYKCEECGKAFNDSSTLMKHKIIHTGK--------- 961

  Fly   215 EDADYEPPKDA----------------PVKSAAQEYKCEHCGKIYHGKYSLRQHLKRDHDNGEEG 263
                 :|.|.|                .:.:..:.||||.|||.::...:|::| |..|..
Human   962 -----KPYKCAECGKAFKQSSHLTRHKAIHTGEKPYKCEECGKDFNNSSTLKKH-KLIHTR---- 1016

  Fly   264 GSAIFTCLECEAQLPRLRLLDEHMVQAHGGA---ACVVCGRRYKTRHELKRHQLKHTSERNVPCP 325
             ..::.|.||.........|.:|.: .|.|.   .|..||:.:|...:|..|::.||.|:  ||.
Human  1017 -EKLYKCEECVKAFNNFSALMKHKI-IHTGEKPYKCEECGKAFKWSSKLTEHKVIHTGEK--PCK 1077

  Fly   326 HPGCGKRFFTIRHMRNHGKVHTEQKNFVCESCGYSCRNKETLRVHIRSHTGERPFGCQVCDKRFP 390
            ...|.|.|.....:|.|..:||.:|.:.|:.||.:..|..||..|...||||:|:.|:.|.|.|.
Human  1078 CEECDKAFKHFSALRKHKVIHTGKKPYQCDECGKAFNNSSTLTKHKIIHTGEKPYKCEECGKAFS 1142

  Fly   391 SHSGLREHMAMHSTERPHVCSVCGATFSRQKGLYHHKFLHADTKQFVCKLCGNAYAQAAGLAGHM 455
            ..|.|.:|..:||.|:|:.|..||..|::...|..||.:|...|.:.|:.||.|:.|.:.|..|.
Human  1143 QSSILTKHKIIHSVEKPYKCEECGKAFNQSSHLTRHKTIHTGEKPYKCEECGKAFIQCSYLIRHK 1207

  Fly   456 RKHRNDE 462
            ..|..::
Human  1208 TIHTREK 1214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2129	NP_572449.1	C2H2 Zn finger	296..316	CDD:275370	6/19 (32%)
		zf-C2H2_8	323..411	CDD:292531	33/87 (38%)
		C2H2 Zn finger	327..346	CDD:275368	5/18 (28%)
		C2H2 Zn finger	354..374	CDD:275368	7/19 (37%)
		zf-H2C2_2	367..389	CDD:290200	10/21 (48%)
		C2H2 Zn finger	382..402	CDD:275368	7/19 (37%)
		zf-H2C2_2	395..419	CDD:290200	10/23 (43%)
		C2H2 Zn finger	410..430	CDD:275368	7/19 (37%)
		C2H2 Zn finger	438..458	CDD:275368	7/19 (37%)
ZNF729	NP_001229609.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	182..202	CDD:275368
		C2H2 Zn finger	210..230	CDD:275368
		C2H2 Zn finger	239..258	CDD:275368
		COG5048	262..666	CDD:227381
		C2H2 Zn finger	266..286	CDD:275368
		C2H2 Zn finger	294..314	CDD:275368
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	351..370	CDD:275368
		zf-H2C2_2	363..386	CDD:290200
		C2H2 Zn finger	378..398	CDD:275368
		C2H2 Zn finger	406..426	CDD:275368
		C2H2 Zn finger	434..454	CDD:275368
		C2H2 Zn finger	462..482	CDD:275368
		zf-H2C2_2	474..499	CDD:290200
		C2H2 Zn finger	490..510	CDD:275368
		zf-H2C2_2	502..527	CDD:290200
		C2H2 Zn finger	518..538	CDD:275368
		zf-H2C2_2	531..554	CDD:290200
		C2H2 Zn finger	546..566	CDD:275368
		C2H2 Zn finger	574..594	CDD:275368
		C2H2 Zn finger	602..622	CDD:275368
		COG5048	625..1123	CDD:227381	73/304 (24%)
		C2H2 Zn finger	630..650	CDD:275368
		zf-H2C2_2	642..667	CDD:290200
		C2H2 Zn finger	658..678	CDD:275368
		zf-H2C2_2	670..695	CDD:290200
		C2H2 Zn finger	686..706	CDD:275368
		zf-H2C2_2	698..722	CDD:290200
		C2H2 Zn finger	714..734	CDD:275368
		C2H2 Zn finger	742..762	CDD:275368
		C2H2 Zn finger	770..790	CDD:275368
		C2H2 Zn finger	798..818	CDD:275368
		C2H2 Zn finger	826..846	CDD:275368
		C2H2 Zn finger	854..874	CDD:275368	3/19 (16%)
		zf-H2C2_2	866..890	CDD:290200	2/24 (8%)
		C2H2 Zn finger	882..902	CDD:275368	6/29 (21%)
		C2H2 Zn finger	910..930	CDD:275368	6/19 (32%)
		C2H2 Zn finger	938..958	CDD:275368	6/19 (32%)
		C2H2 Zn finger	966..986	CDD:275368	1/19 (5%)
		zf-H2C2_2	978..1003	CDD:290200	7/24 (29%)
		C2H2 Zn finger	994..1014	CDD:275368	8/20 (40%)
		C2H2 Zn finger	1022..1042	CDD:275368	5/20 (25%)
		zf-H2C2_2	1034..1058	CDD:290200	7/24 (29%)
		C2H2 Zn finger	1050..1070	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1078..1098	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1106..1126	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1134..1154	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1162..1182	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1190..1210	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930